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Spindle cell endocrine carcinoma of the mammary gland

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Abstract

We report the pathological characteristics of a variant of mammary endocrine tumour, predominantly formed from cytologically bland spindle cells. This neoplasm grows as a red, well defined mass lacking the usual macroscopical characteristics of breast cancer. Within smoothly contoured aggregates arranged in an insular pattern, delicate capillaries and collagen bundles support the neoplastic epithelial cells. Most of the tumour cells possess a slender spindle shape and form a solid or fenestrated sheet, but a few appear cuboidal and create glands. Immunohistochemical studies demonstrate that the spindle cells and the glandular cells constitute a single population. Both types of cells stain for neuroendocrine markers (chromogranin, synaptophysin, and CD 57), carcinoembryonic antigen, keratin 8/18, S-100 protein, and receptors for oestrogen and progesterone. Many of the tumour cells possess argyrophilic granules, and electron microscopy may reveal dense core granules.

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References

  1. Bigotti G, Di Giorgio CG (1986) Myoepithelioma of the breast: histologic, immunologic, and electromicroscopic appearance. J Surg Oncol 32:58–64

    Google Scholar 

  2. Cartagena N Jr, Cabello-Inchausti B, Willis I, Poppiti R Jr (1988) Clear cell myoepithelial neoplasm of the breast. Hum Pathol 19:1239–1243

    Google Scholar 

  3. Cubilla AL, Woodruff JM (1977) Primary carcinoid tumour of the breast. Am J Surg Pathol 1:283–292

    Google Scholar 

  4. Erlandson RA, Rosen PP (1982) Infiltrating myoepithelioma of the breast. Am J Surg Pathol 6:785–793

    Google Scholar 

  5. Fetissof F, Dubois MP, Arbeille-Brassart B, Lansac J, Jobard P (1983) Argyrophilic cells in mammary carcinoma. Hum Pathol 14:127–134

    Google Scholar 

  6. Maiorano E, Rico R, Virgintino D, Lastilla G (1994) Infiltrating myoepithelioma of the breast. Appl Immunohistochem 2:130–136

    Google Scholar 

  7. Maluf H, Koerner FC (1995) Solid papillary carcinoma of the breast. A form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma. Am J Surg Pathol 19:1237–1244

    Google Scholar 

  8. Maluf HM, Zukerberg LR, Dickersin GR, Koerner FC (1991) Spindle cell mucin producing argyrophilic carcinoma of the breast. Histological, ultrastructural and immunohistological studies of two cases. Am J Surg Pathol 15:677–686

    Google Scholar 

  9. Papotti M, Macri L, Finzi G, Capella C, Eusebi V, Bussolati G (1989) Neuroendocrine differentiation in carcinomas of the breast: a study of 51 cases. Semin Diagn Pathol 6:174–188

    Google Scholar 

  10. Rode L, Nesland JM, Johannessen JV (1986) Case 6: a spindle cell breast lesion in a 54-year-old woman. Ultrastruct Pathol 10:421–425

    Google Scholar 

  11. Rosen PP (1987) Adenomyoepithelioma of the breast. Hum Pathol 18:1232–1237

    Google Scholar 

  12. Rosen PP, Oberman HA (1993) Tumors of the mammary gland. Atlas of tumor pathology, 3rd ser. Armed Forces Insti tute of Pathology, Washington, DC

    Google Scholar 

  13. Saez A, Serrano T, Azpeitia D, Condom E, Moreno A (1992) Adenomyoepithelioma of the breast. A report of two cases. Arch Pathol Lab Med 116:36–38

    Article  CAS  PubMed  Google Scholar 

  14. Schurch W, Potvin C, Seemayer TA (1985) Malignant myoepithelioma (myoepithelial carcinoma) of the breast: an ultrastructural and immunocytochemical study. Ultrastruct Pathol 8:1–11

    Google Scholar 

  15. Soares J, Tomasic G, Bucciarelli E, Eusebi V (1994) Intralobular growth of myoepithelial cell carcinoma of the breast. Virchows Arch 425:205–210

    Google Scholar 

  16. StatPath (1990) Microwave oven methods in pathology, sect. 6. Statfath, Riverwood, Md, pp 28–29

  17. Tamai M (1992) Intraductal growth of malignant mammary myoepithelioma. Am J Surg Pathol 16:1116–1125

    Google Scholar 

  18. Tavassoli FA (1991) Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol 15:554–568

    Google Scholar 

  19. Tavassoli FA (1992) Pathology of the breast. Elsevier, New York, pp 321–326

    Google Scholar 

  20. Thorner PS, Kahn HJ, Baumal R, Lee K, Moffatt W (1986) Malignant myoepithelioma of the breast. An immunohistochemical study by light and electron microscopy. Cancer 57:745–750

    Google Scholar 

  21. Toth J (1977) Benign human mammary myoepithelioma. Virchows Arch [A] 374:263–269

    Google Scholar 

  22. Trojani M, Guiu M, Trouette H, De Mascarel I, Cocquet M (1992) Malignant adenomyoepithelioma of the breast. An immunohistochemical, cytophotometric, and ultrastructural study of a case with lung metastases. Am J Clin Pathol 98:598–602

    Google Scholar 

  23. Weidner N, Levine JD (1988) Spindle-cell adenomyoepithelioma of the breast. A microscopic, ultrastructural, and immunocytochemical study. Cancer 62:1561–1567

    Google Scholar 

  24. Young RH, Clement B (1988) Adenomyoepithelioma of the breast. A report of three cases and review of the literature. Am J Clin Pathol 89:308–314

    Google Scholar 

  25. Zarbo RJ, Oberman HA (1983) Cellular adenomyoepithelioma of the breast. Am J Surg Pathol 7:863–870

    Google Scholar 

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Authors and Affiliations

  1. James Homer Wright Laboratory of Pathology, Massachusetts General Hospital, Fruit Street, 02114, Boston, MA, USA

    E. F. Ruffolo & F. C. Koerner

  2. Pathology and Laboratory Medical Service, Veterans Administration Medical Center, 1030 Jefferson Avenue, 38104, Memphis, TN, USA

    H. M. Maluf

Authors
  1. E. F. Ruffolo
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  2. F. C. Koerner
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  3. H. M. Maluf
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Ruffolo, E.F., Koerner, F.C. & Maluf, H.M. Spindle cell endocrine carcinoma of the mammary gland. Vichows Archiv A Pathol Anat 428, 319–324 (1996). https://doi.org/10.1007/BF00202198

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  • DOI: https://doi.org/10.1007/BF00202198

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