Skip to main content
SpringerLink
Log in

The acetylation phenotype: does it contribute to the non-linearity of the metabolite pharmacokinetics of metamizol?

  • Letter to the Editors
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Volz M, Kellner HM (1980) Kinetics and metabolism of pyrasolones (propyphenazone, aminopyrine, dipyrone). Br J Clin Pharmacol 10 [Suppl 2]: 299–308

    Google Scholar 

  2. Vlahov V, Badian M, Verho M, Bacracheva N (1990) Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium. Eur J Clin Pharmacol 38: 61–65

    Google Scholar 

  3. Levy M, Flusser D, Zylber-Katz E, Granit L (1984) Plasma kinetics of dipyrone metabolites in rapid and slow acetylators. Eur J Clin Pharmacol 2: 453–458

    Google Scholar 

  4. Damm D (1989) Simultaneous determination of the main metabolites of dipyrone by HPLC. Arzneimittelforschung/Drug Res 39: 1415–1417

    Google Scholar 

  5. Zylber-Katz E, Granit L, Levy M (1992) Formation and excretion of dipyrone metabolites in man. Eur J Clin Pharmacol 42: 187–191

    Google Scholar 

  6. Boobis AR, Brodie MJ, Kahn CC, Toverud EL, Blair IA, Murray SS, Davies DS (1981) Comparison of the in vivo and in vitro rates of formation of the three main oxidative metabolites of antipyrine in man. Br J Clin Pharmacol 12: 771–777

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, Medical Faculty, University Hospital “Queen Giovanna”, 8 Belo more Street, 1040, Sofia, Bulgaria

    N. Bacracheva & V. Vlahov

Authors
  1. N. Bacracheva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Vlahov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bacracheva, N., Vlahov, V. The acetylation phenotype: does it contribute to the non-linearity of the metabolite pharmacokinetics of metamizol?. Eur J Clin Pharmacol 48, 79–80 (1995). https://doi.org/10.1007/BF00202178

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00202178

Key words

Search

Navigation