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IL-6 cytokine family and signal transduction: a model of the cytokine system

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Abstract

The interleukin 6 (IL-6) cytokine family, which includes IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), IL-11 and cardiotrophin-1 (CT-1), exhibits pleiotropy and redundancy in biological activities. The IL-6 family cytokines exhibit a helical structure. Their receptors belong to the type 1 cytokine receptor family. The receptors of the IL-6 family cytokines share a receptor subunit, which explains one of the mechanisms of functional redundancy. In this review, we describe the general features of the IL-6 cytokine family and its signal transduction mechanisms. Many functional properties of the IL-6 family of cytokines and their receptors are general features of the cytokine system.

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Abbreviations

IL-6 :

Interleukin 6

LIF :

Leukemia inhibitory factor

OSM :

Oncostatin M

CNTF :

Ciliary neurotrophic factor

CT-1 :

Cardiotrophin-1

IFN :

Interferon

G-CSF :

Granulocyte colony-stimulating factor

GM-CSF :

Granulocyte-macrophage colony-stimulating factor

Epo :

Erythropoietin

JAK :

Janus kinase

STAT :

Signal transducers and activators of transcription

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Hibi, M., Nakajima, K. & Hirano, T. IL-6 cytokine family and signal transduction: a model of the cytokine system. J Mol Med 74, 1–12 (1996). https://doi.org/10.1007/BF00202068

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