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Immunoregulation by parasite extracts

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Conclusion

From the many experimental results reported above, it appears reasonable to suggest that parasites take an active part in the regulation of the host immune response that they have themselves evoked. For several workers, the immunodepression and polyclonal B-cell activation observed in most parasitic infections, are linked phenomena. Can parasite-derived factors account for this dysregulation of the host immune system and are these substances of any relevance for the understanding of the host-parasite relationship and the development of immunity to parasite infection? Many observations made in recent years are consistent with the general concept that among many possible mechanisms, molecules from a parasite origin have a direct role on the regulation of the activity of several cell populations. However, so far this concept relies only on the biologic activity of crude parasitic material mostly demonstrated by in vitro experiments. We believe that an extensive study of these putative substances might be of extreme theoretical and practical interest. At the present stage of our knowledge precise biochemical characterization of these factors is required. Similarly, exact evaluation of their role in vivo and of their interactions with the immune system during parasitic infection is necessary. Their mode of action at the cell membrane level has also to be elucidated. However, all evidence obtained until now allows one to consider that parasite-derived immunomodulating substances might represent a potent escape mechanism and an essential feature of the host-parasite relationship. Moreover, parasites might represent in this respect a unique source of immunoregulatory substances and provide therefore a privileged model for immunopharmacologic studies.

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Authors and Affiliations

  1. Centre d'Immunologie et de Biologie Parasitaire, INSERM U 167, ERA CNRS 422, Institut Pasteur, F-59019, Lille Cedex, France

    André Capron & Daniel Camus

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  1. André Capron
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  2. Daniel Camus
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Capron, A., Camus, D. Immunoregulation by parasite extracts. Springer Semin Immunopathol 2, 69–77 (1979). https://doi.org/10.1007/BF00201974

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