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Lymphocyte proliferation, lymphokine production, and lymphocyte receptors in ageing and various clinical conditions

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The combination of cytofluorographic analysis of human or murine lymphocytes moving through various phases of the cell cycle following lectin stimulation, determination of DNA synthesis by 3H-thymidine uptake, quantitative assessment of lymphokines produced in culture supernatants (e.g. IL 2), and evaluation of various cellular receptors (e.g. IL 2, insulin, corticosteroid) by fluorescent antireceptor monoclonal antibodies or binding of radiolabeled ligand permit one to develop a more comprehensive picture of the defects in lymphocyte functions which are associated with aging and various other clinical conditions.

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  1. Institute of Clinical Immunology, Inselspital, University of Bern, CH-3010, Bern, Switzerland

    Alain L. de Weck, Flemming Kristensen, Franziska Joncourt, Florence Bettens, Christoph Walker & Yarxing Wang

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  1. Alain L. de Weck
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de Weck, A.L., Kristensen, F., Joncourt, F. et al. Lymphocyte proliferation, lymphokine production, and lymphocyte receptors in ageing and various clinical conditions. Springer Semin Immunopathol 7, 273–289 (1984). https://doi.org/10.1007/BF00201961

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