Skip to main content
SpringerLink
Log in

Direct screening of a mitochondrial DNA deletion valuable for Amerindian evolutionary research

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Abstract

A rapid, simple restriction isotyping method is described for the direct screening of a previously characterized Amerindian mitochondrial DNA (mtDNA) marker consisting of a 6-bp “Huetar” deletion. In a sample of 31 maternally non-related Chibchan Amerindian Bribri from Costa Rica, this deletion was present in 74%, arguing for the usefulness of this private polymorphism for Amer-indian taxonomic research.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Anderson S, Bankier AT, Barrell BG, Bruijn MHL, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AHJ, Staden R, Young IG (1981) Sequence and organization of the human mitochondrial genome. Nature 290:457–464

    CAS  PubMed  Google Scholar 

  • Ballinger SW, Schurr TG, Torroni A, Gan Y-Y, Hodge JA, Hassan K, Chen K-H, Wallace D (1992) Southeast Asian mitochondrial DNA analysis reveals genetic continuity of ancient mongoloid migrations. Genetics 130:139–152

    Google Scholar 

  • Barrantes R, Smouse PE, Mohrenweiser HW, Gershowitz H, Asofeifa J, Arias TD, Neel JV (1990) Microevolution in Lower Central America: genetic characterization of the Chibchaspeaking groups of Costa Rica and Panama, and a consensus taxonomy based on genetic and linguistic affinity. Am J Hum Genet 46:63–84

    Google Scholar 

  • Guevara M Chacón (1992) Territorios indios de Costa Rica: orígenes, stiuación actual y perspectivas. García Hernández, San José

    Google Scholar 

  • Horai M, Konde R, Nakagawa-Hattori Y, Hayashi N, Sonoda S, Tajima K (1993) Peopling of the Americas, founded by four major lineages of mitochondrial DNA. Mol Biol Evol 10: 23–47

    CAS  PubMed  Google Scholar 

  • Santos M (1992) Análisis de variación genética del ADNmt y nuclear de una población Amerindia, Huetar, Costa Rica. M.Sc. Thesis, Universidad de Costa Rica

  • Santos M, Barrantes R, Ward R: MtDNA variation in the Chibcha Amerindian Huetar from Costa Rica

  • Thompson EA, Neel JV, Smouse PE, Barrantes R (1992) Microevolution of the Chibcha-speaking peoples of Lower Central America: rare genes in an Amerindian complex. Am J Hum Genet 51:609–626

    Google Scholar 

  • Torroni A, Schurr TG, Yang CG, Szathmary EGE, Williams RC, Schanfield MS, Troup GA, Knowler WC, Lawrence DN, Weiss KM, Wallace DC (1992) Native American mitochondrial DNA analysis indicates that the Amerind and the Nadene populations were founded by two independent migrations. Genetics 130:153–162

    Google Scholar 

  • Ward RH, Frazier B, Dew K, Pääbo S (1991) Extensive mitochondrial diversity within a single Amerindian tribe. Proc Natl Acad Sci USA 88:8720–8724

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section de Genética Humana, Instituto de Investigaciones en Salud (INISA), Universidad de Costa Rica, San José, Costa Rica

    Maria Santos & Ramiro Barrantes

Authors
  1. Maria Santos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ramiro Barrantes
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Santos, M., Barrantes, R. Direct screening of a mitochondrial DNA deletion valuable for Amerindian evolutionary research. Hum Genet 93, 435–436 (1994). https://doi.org/10.1007/BF00201670

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00201670

Keywords

Search

Navigation