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Structure-toxicity relationships for unsaturated alcohols to Tetrahymena pyriformis: C5 and C6 analogs and primary propargylic alcohols


In summary, the relative toxicity of selected unsaturated alcohols were evaluated in the static Tetrahymena pyriformis population growth assay. The alkyn-1-ols were found to be more toxic than alken-1-ols. Moreover, 2-position unsaturated derivatives were more toxic than other isomers. A linear log Kow dependent relationship was generated (slope = 0.64; intercept = −0.61; r2 = 0.974) for selected 2-alkyn-1-ols. However, the diols were observed to be more toxic than predicted.

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  1. Dawson DA, Schultz TW, Baker LL, Wilke TS (1990) Comparative developmental toxicity of acetylenic alcohols on embryos and larvae of Xenopus laevis. In: Landis WG, van der Schalie WH (eds) Aquatic toxicity and risk assessment: thirteenth volume, ASTM STP 1096, American Society for Testing and Materials, Philadelphia, pp 267–277

    Google Scholar 

  2. Hansch C, Steward AR, Anderson SM, Bentley DL (1967) The parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics. J Med Chem 11:1–11

    Google Scholar 

  3. Könemann H (1981) Quantitative structure-activity relationships in fish toxicity studies Part 1: Relationship for 50 industrial pollutants. Toxicology 19:209–221

    Google Scholar 

  4. Leo A, Weininger D (1988) Medchem software release 3.53, Pomona Medical Chemistry Project, Pomona College, Claremont, California

    Google Scholar 

  5. Lipnick RL (1985) Validation and extension of fish toxicity QSARs and interspecies comparisons for certain classes of organic chemicals. In: Tichy M (ed) QSAR in toxicology and xenobiochemistry, Elsevier, Amsterdam, pp 39–52

    Google Scholar 

  6. Lipnick RL, Johnson DE, Gilford JH, Bickings CK, Newsome LD (1985) Comparison of fish toxicity screening data for 55 alcohols with the quantitative structure activity relationship predictions of minimum toxicity for non-reactive non-electrolytic organic compounds. Environ Toxicol Chem 4:281–296

    Google Scholar 

  7. Lipnick RL, Watson KR, Strausz AK (1987) A QSAR study of the acute toxicity of some industrial organic chemicals to goldfish. Narcosis, electrophiles and proelectrophile mechanisms. Xenobiotica 17:1011–1025

    Google Scholar 

  8. Roberts DW (1989) Acute lethal toxicity quantitative structure-activity relationships for electrophiles and proelectrophiles: Mechanistic and toxicokinetic principles. In: Suter GW II, Lewis MA (eds) Aquatic toxicity and environmental fate: eleventh volume, ASTM STP 1007, American Society for Testing and Materials, Philadelphia, pp 490–506

    Google Scholar 

  9. SAS Institute Inc. (1989) SAS/STAT user's guide, version 6, fourth edition, vol 2, Cary, North Carolina, pp 846

    Google Scholar 

  10. Schultz TW, Arnold LM, Wilke TS, Moulton MP (1990a) Relationships of quantitative structure-activity for normal aliphatic alcohols. Ecotoxicol Environ Saf 19:243–253

    CAS  PubMed  Google Scholar 

  11. Schultz TW, Lin DT, Wilke TS, Arnold LM (1990b) Quantitative structureactivity relationships for the Tetrahymena pyriformis population growth endpoint: A mechanisms of action approach. In: Karcher W, Devillers J (eds) Practical applications of quantitative structure-activity relationships (QSAR) in environmental chemistry and toxicology, Kluwer Academic Publishers, Dordrecht, The Netherlands, pp 241–262

    Google Scholar 

  12. Schultz TW, Wyatt NL, Lin DT (1990c) Structure-toxicity relationships for nonpolar narcotics: A comparison of data from the Tetrahymena, Photobacterium and Pimephales systems. Bull Environ Contam Toxicol 44:67–72

    Google Scholar 

  13. Veith GD, Call DJ, Brooke LT (1983) Structure-toxicity relationships for the fathead minnow, Pimephelas promelas: Narcotic industrial chemicals. Canad J Fish Aquatic Sci 40:743–748

    Google Scholar 

  14. Veith GD, Lipnick RL, Russom CL (1989) The toxicity of acetylenic alcohols to the fathead minnow, Pimephales promelas: Narcosis and proelectrophilic activation. Xenobiotica 19:555–565

    Google Scholar 

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Correspondence to T. Wayne Schultz.

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Schultz, T.W., Tichy, M. Structure-toxicity relationships for unsaturated alcohols to Tetrahymena pyriformis: C5 and C6 analogs and primary propargylic alcohols. Bull. Environ. Contam. Toxicol. 51, 681–688 (1993).

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  • Alcohol
  • Toxicity
  • Waste Water
  • Water Management
  • Water Pollution