In summary, the relative toxicity of selected unsaturated alcohols were evaluated in the static Tetrahymena pyriformis population growth assay. The alkyn-1-ols were found to be more toxic than alken-1-ols. Moreover, 2-position unsaturated derivatives were more toxic than other isomers. A linear log Kow dependent relationship was generated (slope = 0.64; intercept = −0.61; r2 = 0.974) for selected 2-alkyn-1-ols. However, the diols were observed to be more toxic than predicted.
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Schultz, T.W., Tichy, M. Structure-toxicity relationships for unsaturated alcohols to Tetrahymena pyriformis: C5 and C6 analogs and primary propargylic alcohols. Bull. Environ. Contam. Toxicol. 51, 681–688 (1993). https://doi.org/10.1007/BF00201645
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