Abstract
We have constructed a linkage map of 14 short tandem repeat polymorphisms (11 with heterozygosity > 70%) on the long arm of human chromosome 22 using 23 non-CEPH pedigrees. Twelve of the markers could be positioned uniquely with a likelihood of at least 1,000:1, and distributed at an average distance of 6.62 cM (range 1.5–16.1 cM). The sex-combined map covers a total of 79.6 cM, the female map 93.2 cM and the male map 64.6 cM. Based on comparisons between physical maps and other genetic maps, we estimate that our map covers 70%–80% of the chromosome. The map integrates markers from previous genetic maps and uniquely positions one marker (D22S307). Data from physical mapping on the location of four genetic markers correlates well with our linkage map, and provides information on an additional marker (D22S315). This map will facilitate high resolution mapping of additional polymorphic loci and disease genes on chromosome 22, and act as a reference for building and verifying physical maps.
Similar content being viewed by others
References
Dumanski JP, Carlbom E, Collins VP, Nordenskjöld M, Emmanuel BS, Budarf ML, McDermid HE, Wolff R, O'Connell P, White R, Lalouel JM, Leppert M (1991) A map of 22 loci on human chromosome 22. Genomics 11:709–719.
Emanuel BS, Buetow K, Nussbaum R, Scambler P, Lipinski M, Overton C (1993) Report of the third international workshop on human chromosome 22 mapping. Cytogenet Cell Genet 63:206–211.
Gill M, McGuffin, Parfitt E, Mant R, Arsherson P, Collier D, Vallada H, Powell JF, Shaikh S, Taylor C, Sargeant M, Clements A, Nanko S, Takazawa N, Llewellyn D, Williams J, Whatley S, Murray R, Owen M (1993) A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11. Psychol Med 23:27–44.
Holt M, Rains D, Steinbrueck T, Weber JL, Donis-Keller H (1992) A comprehensive genetic linkage map of human genome. Science 258:67–86.
Kosambi DD (1944) The estimation of map distances from recombination values. Ann Eugen 12:172–175.
Lander ES, Green P (1987) Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci USA 84:2363–2367.
Lincoln SE, Lander ES (1992) Systematic detection of errors in genetic linkage data. Genomics 14:604–610.
Reeves RH, Crowley MR, O'Hara BF, Gearhart JD (1990) Sex, strain, and species differences affect recombination across an evolutionarily conserved segment of mouse chromosome 16. Genomics 8:141–148.
Rouleau GA, Haines JL, Bazanowski A, Colella-Crowley A, Trofatter JA, Wexler NS, Conneally M, Gusella JF (1989) A genetic linkage map of the long arm of human chromosome 22. Genomics 4:1–6.
Trofatter JA, MacCollin MM, Rutter JL, Murrel JR, Duyao MP, Parry DM, Eldridge R, Kley N, Menon AG, Pulaski K, Haase VH, Ambrose CM, Munroe D, Bove C, Haines JL, Martuza RL, MacDonald E, Seizinger BR, Short MP, Buckler AJ, Gusella JF (1993) A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumour suppressor. Cell 72:791–800.
Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette J, Millasseau P, Vaysseix G, Lathrop M (1992) A second-generation linkage map of the human genome. Nature 359:794–801.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vallada, H.P., Collins, J.E., Dunham, I. et al. Genetic mapping of 14 short tandem repeat polymorphisms on human chromosome 22. Hum Genet 93, 688–690 (1994). https://doi.org/10.1007/BF00201571
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00201571