Summary
An acute ethanol dose of 2g/kg shortened the survival time at −20°C of guinea pigs both adapted to the cold and those reared in the warm, but no significant difference was observed between the adapted and non-adapted groups. Long-term ethanol treatment of 2g/kg/day for 4 weeks, lengthened the survival time of the guinea pigs reared at room temperature, but did not affect the survival of the cold-adapted animals. The acute dose of 2g/kg shortened the survival time of the guinea pigs which had received the 4-week ethanol treatment and had been reared in the warm, but did not have the same effect on the cold-adapted animals. The improved survival rate at severe exposure acquired by adaptation to the cold was abolished by chronic alcohol administration.
Zusammenfassung
Eine akute Äthanoldosis von 2g/kg verkürzte die Lebenszeit von Meerschweinchen, die entweder akklimatisiert oder nicht-akklimatisiert waren. Von den Tieren, die Äthanol 2g/kg täglich vier Wochen lang erhalten hatten, lebten die nicht-akklimatisierten Tiere länger als die akklimatisierten. Von den Tieren, die 4 Wochen Äthanol erhalten hatten und vor der Kälteexposition noch eine akute Dosis erhielten, starben die nicht-akklimatisierten schneller, aber bei den akklimatisierten blieb die Dosis ohne Wirkung.
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This work was supported by a grant from the Finnish Foundation for Alcohol Studies
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Huttunen, P., Penttinen, J. & Hirvonen, J. The effect of ethanol and cold-adaptation on the survival of guinea pigs in severe cold. Z Rechtsmed 85, 289–294 (1980). https://doi.org/10.1007/BF00201292
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DOI: https://doi.org/10.1007/BF00201292