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Pathologisch-anatomische befunde bei plötzlichem, unerwartetem tod von kindern und erwachsenen mit influenza-A-infektion

Pathological findings in cases of sudden death of uncertain cause in infants (SIDS) and adults and influenza-A-infection

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Summary

The following observations resulted from studies on forensic autopsy cases:

  1. 1.

    In 76% of the adults and 55% of the infants the cases of unexpected sudden death without morphologically verifiable causes of death showed virologic evidence of recent influenza-A(H3N2)-infection. The pathologic findings corresponded with the findings in lethal infections with influenza-A-viruses.

  2. 2.

    Investigation of cases of sudden and unexpected death should always include virologic serum tests. The demonstration of IgM antibodies against influenza-A virus confirms that there was a recent infection. Death from influenza-A infections occurs also in the interepidemic periods.

Zusammenfassung

Untersuchungen an gerichtsmedizinischen Obduktionsfällen ergaben:

  1. 1.

    Beim plötzlichen und unerwarteten Tod im Säuglings- und Erwachsenenalter ohne morphologisch faßbare Todesursache fand sich in unserem Material bei 76% der Erwachsenen und bei 55% der Säuglinge und Kleinkinder virologisch eine rezente Influenza-A(H3N2)-Infektion. Die bei diesen Fällen zu beobachtenden pathologisch-anatomischen Befunde entsprachen weitgehend denen bei Todesfällen mit Influenza.

  2. 2.

    Bei der Untersuchung unklarer plötzlicher Todesfälle sollte auf eine virologische Untersuchung von Blut nicht verzichtet werden. Ein Nachweis von IgM-Antikörpern gegen Influenza-A-Viren beweist den frischen Infekt. Mit tödlich verlaufenden Influenza-A-Infektionen ist auch in der Zeit zwischen Grippeepidemien zu rechnen.

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Literatur

  • Adams JM (1941) Primary virus pneumonitis with cytoplasmic inclusion bodies, study of an epidemic involving thirty-two infants, with nine deaths. JAMA 116:925–933

    Google Scholar 

  • Adams JM, Imagawa DT, Zike K (1961) Epidemic bronchiolitis and pneumonitis related to respiratory syncytial virus. JAMA 176:1037–1039

    Google Scholar 

  • Adelson L (1953) Possible neurological mechanisms responsible for sudden death with minimal anatomical findings. J Forensic Med 1:39–45

    Google Scholar 

  • Aherne W, Bird T, Court SDM, Gardener PS, McQuillin J (1970) Pathological changes in virus infections of the lower respiratory tract in children. J Clin Pathol 23:7–18

    Google Scholar 

  • Althoff H (1973) Der plötzliche und unerwartete Tod von Säuglingen und Kleinkindern. Fischer, Stuttgart

    Google Scholar 

  • Althoff H (1980) Sudden infant death syndrome (S.I.D.S.). Fischer, Stuttgart

    Google Scholar 

  • Althoff H (1982) Praxisorientierte Erfahrungen über plötzliche Todesfälle. Zentralbl Rechtsmed 24:79–83

    Google Scholar 

  • Althoff H (1984) Nebennierenentwicklung und plötzlicher Kindstod. Kriminal Forensic Wiss 55/56:116–120

    Google Scholar 

  • Bauer DC, Stavitsky AB (1961) On the different molecular forms of antibody synthesized by rabbits during the early response to a single infection of protein and cellular antigens. Proc Natl Acad Sci USA 47:1676–1679

    Google Scholar 

  • Beckmann G, Henn R (1974) Hämorrhagische Pneumonie und plötzlicher Tod. Z Rechtsmedizin 74:283–292

    Google Scholar 

  • Bellwald M (1982) Autopsien mit unbefriedigenden Resultaten. Schweiz Med Wochenschr 112:75–82

    Google Scholar 

  • Berg S, Kijewski S (1978) Histologische Befunde an 224 Fällen von plötzlichem Säuglingstod im norddeutschen Raum. Beitr Gerichtl Med 36:153–160

    Google Scholar 

  • Bergmann AB, Ray CG, Pomeroy MA, Wahl PW, Beckwith JB (1972) Studies of the sudden infant death syndrome in King county, Washington. III. Epidemiology. Pediatrics 49:860–870

    Google Scholar 

  • Beveridge WJB, Burnet FM (1946) The cultivation of viruses and Rickettsia in the chick embryo. Med Res Cournc Spec Rep Ser, London, pp 1–92

    Google Scholar 

  • Bishai FR, Galli R (1978) Enzyme-linked immunosorbent assay for detection of antibodies to influenza A and B and parainfluenza type 1 in sera of patients. J Clin Microbiol 8:648–656

    Google Scholar 

  • Bisno AC, Griffin JP, v Epps KA, Niell HB, Rytel MW (1971) Pneumonia and Hong Kong influenza: a prospective study of the 1968–1969 epidemic. Am J Med Sci 261:251–263

    Google Scholar 

  • Blandfort G (1970) Arthur reaction and pneumonia. Br Med J 1:758–759

    Google Scholar 

  • Böhm N (1984) Plötzlicher Säuglingstod. In: Kinderpathologie, Farbatlas und Lehrbuch der pädiatrischen Autopsiepathologie. Schattauer, Stuttgart, S 210–211

    Google Scholar 

  • Boemke F (1947) Der plötzliche Tod aus natürlicher Ursache bei Soldaten während des vergangenen Krieges. Frankf Z Pathol 59:104–142

    Google Scholar 

  • Bonser RSA, Knight BH, West RR (1978) Sudden infant death syndrome in Cardiff, association with epidemic influenza and with temperature — 1955–1974. Int J Epidemiol 7:335–340

    Google Scholar 

  • Borden CW (1950) Acute myocarditis report of a case with observation on the etiologic factor. Am Heart J 39:131–135

    Google Scholar 

  • Borst M (1918) Pathologisch-anatomische Beobachtungen zur „spanischen Grippe“ 1918. Münch Med Wochenschr 65:1342–1344

    Google Scholar 

  • Boyer KM, Cherry JD, Welliver RC, Dudley JP, Deseda-Tous J, Zahradnik JM, Krause PJ, Spencer MJ, Bryson YJ, Garakian AJ (1977) IgM and IgG antibody responses after immunication of children with inactivated monovalent (A/New Jersey/76) and bivalent (A/New Jersey/76-A/Victoria/75) influenza virus vaccines. J Infect Dis 136 [Suppl]:665–671

    Google Scholar 

  • Brandt CD, Parrott RH, Patrick JR, Kim HW, Arrobio JO, Chandra R, Jeffries BC, Channock RM (1974) SIDS and viral respiratory disease in Metropolitan Washington DC. In: Robinson RM (ed) Proceedings of the Francis E. Camps international symposium on sudden and unexpected death in infancy. Toronto, pp 117–129

  • Brocklebank JT, Court SDM, McQuillin J, Gardner PS (1972) Influenza-A-infection in children. Lancet II:497–500

    Google Scholar 

  • Buchner YI, Heath RB, Collins JV, Pettinson JR (1977) Serum IgM antibody and influenza A infection. J Clin Pathol 30:723–727

    Google Scholar 

  • Bundesamt für Gesundheitswesen (Schweiz), Sektion übertragbare Krankheiten (1984) Grippe und Grippeimpfung. Bulletin des Bundesamtes für Gesundheitswesen 38:552–555

    Google Scholar 

  • Burch G, Walsh J, Mogabgab W (1961) Study of the response of the cardiovascular system to Asian influenza. Am Rev Respir Dis 83:68–78

    Google Scholar 

  • Burlington DB, Clements ML, Meiklejohn G, Phelan M, Murphy BR (1983) Hemagglutinin-specific antibody responses in immunoglobulin G, A and M isotypes as measured by enzyme-linked immunosorbent assay after primary or secondary infection of humans with influenza A virus. Infect Immun 41:540–595

    Google Scholar 

  • Busse O (1919) Zur pathologischen Anatomie der Grippe. Münch Med Wochenschr 66:119–121

    Google Scholar 

  • Carilli AD, Gohd RD, Gordon W (1964) A virologic study of chronic bronchitis. New Engl J Med 270:123–127

    Google Scholar 

  • Centers for Disease Control (1983) Influenza surveillance summary-United States, 1982–83 season. Morbidity and mortality weekly report 32:373–377

    Google Scholar 

  • Centers for Disease Control (1984) Influenza activity-Northern hemisphere, 1984. Morbidity and mortality weekly report 33:651–652; U.S. Department of Health and Human Services. Recommendation of the immunization, practices advisory committee (ACIP): Prevention and control of influenza. Morbidity and mortality weekly report 33:253–358

  • Chanock RM (1974) From the National Institutes of Health: Influenza vaccines; summary of influenza workshop V: Target populations for vaccination. J Infect Dis 129:755–758

    Google Scholar 

  • Committee on standard serologic procedures in influenza studies (1960) An agglutionation inhibition test proposed as a standard of reference in influenza diagnostic studies. J Immunol 65:347–353

    Google Scholar 

  • Cradock-Watson JE, Ridehalgh MKS, Chantler S (1976) Specific immunoglobulins in infants with the congenital rubella syndrome. J Hyg Camb 76:109–123

    Google Scholar 

  • Dauer CC (1958) Mortality in the 1957–58 influenza epidemic. Publ Health Rep (Wash) 73:803–810

    Google Scholar 

  • Dauer CC, Serfling RE (1961) Mortality from influenza. Am Rev Dis [Suppl] 83:15–28

    Google Scholar 

  • Deacon EL, O'Reilly MJJ, Williams AL (1979) Some statistical and climatological aspects of the incidence of the sudden infant death syndrome. Am Paediatr J 15:248–254

    Google Scholar 

  • Diamond I (1958) A review of sudden and unexplained death in children. J Ky Med Assoc 56:38–41

    Google Scholar 

  • Dingle JH, Badger EF, Jordon WS jr (1964) Illness in the home. The Press of Western Reserve University Cleveland

  • Doerr HW (1980) Virologische Technik für den Sektionssaal. Pathologe 1:220–229

    Google Scholar 

  • Douglas RG jr (1975) Influenza in man. In: Kilbourne ED (ed) The influenza viruses and influenza. Academic Press, New York, pp 395–447

    Google Scholar 

  • Douglas RG jr (1979) Respiratory diseases. In: Galasso GJ, Merigan TC, Buchanan RA (eds) Antiviral agents and viral diseases in man. Raven Press, New York, pp 385–459

    Google Scholar 

  • Dowdle WR, Noble GR, Kendale AP (1977) Orthomyxovirus-Influenza: Compartive diagnosis, unifying concept. In: Kurstak E, Kurstak KC (eds) Comparative diagnosis of viral diseases. Academic Press, New York (Vol 1, pp 447–501)

    Google Scholar 

  • Drescher J (1957) Über Hämagglutinin- und Antikörpergehaltsbestimmungen. I. Mitteilung: Beschreibung eines photometrischen Verfahrens zur Virusgehaltsbestimmung. Zentralbl Bakteriol 169:314–348

    Google Scholar 

  • Drescher J (1957) Über Hämagglutinin- und Antikörpergehaltsbestimmungen. II. Mitteilung: Untersuchungen über die eine Hämagglutination hemmenden Antikörper und Beschreibung eines photometrischen Verfahrens zur Antikörpergehaltsbestimmung. Zentralbl Bakteriol 169:461–470

    Google Scholar 

  • Drescher J (1983) Influenza. Verhandlungsbericht der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Arch Otorhinolaryngol [Suppl] I:113–187

    Google Scholar 

  • Drescher J, Hennessy AV, Davenport FM (1962) Photometric methods for the measurement of hemagglutinating viruses and antibody. J Immunol 89:794–804, 805–814

    Google Scholar 

  • Drescher J, Zink P, Verhagen W, Flik J, Milbradt H (1986) Recent influenza A infections in forensic cases of sudden unexplained death. Arch Virol (im Druck)

  • Fekety FR, Caldwell J, Gump D, Johnson JE, Maxson W, Mulholland D, Thoburn R (1971) Bacteria, viruses and mycoplasmas in acute pneumonia in adults. Am Rev Resp Dis 104:499–507

    Google Scholar 

  • Emery JL (1962) Certification of death by the pathologist. Proc Soc Med 55:738–740

    Google Scholar 

  • Fox JP, Hall CE, Cooney MK, Foy HM (1982) Influenza virus infections in Seattle families, 1975–1979. Am J Epidemiol 116:212–227

    Google Scholar 

  • Francis T, Maassab HF (1965) Influenza viruses. In: Horsfall FL jr, Tamm I (eds) Viral and rickettsial infections of man. Lippincott, Philadelphia (4th ed, pp 689–740)

    Google Scholar 

  • Fry J (1969) Epidemic influenza: Pattern over 20 year (1949–1968). J R Coll Gen Pract [Occas Pap] 17:100–103

    Google Scholar 

  • Gardener CE (1970) Virological studies of the sudden infant death syndrome in Multnomah County, Oregon. In: Bergmann AB, Beckwith JB, Ray CG (eds) Sudden infant death syndrome. University of Washington Press, Seattle London, S 156–157

    Google Scholar 

  • Gillner E, Lignitz E, Rittner Ch (1976) Der plötzliche Tod aus natürlicher Ursache. In: Prokop P, Göhler W (Hrsg) Forensische Medizin. Fischer, Stuttgart New York, 3. Aufl, S 85–102

    Google Scholar 

  • Glenzen WP, Payne AA, Snyder DN, Downs TD (1982) Mortality and influenza. J Infect Dis 146:313–321

    Google Scholar 

  • Gloggengiesser W (1955) Plötzliche Todesfälle. a) Herztod, b) Grippetod. Münch Med Wochenschr 97:1314–1316

    Google Scholar 

  • Gold E, Carver DH, Heineberg H, Adelson L, Robbins FC (1961) Viral infection. A possible cause of sudden unexpected death in infants. New Engl J Med 264:53–60

    Google Scholar 

  • Goldwater PN, Webster M, Banatvala JE (1982) Use of a simple new test for virus specific IgM to investigate an outbreak of influenza B in a hospitalized aged community. J Virol Methods 4:9–18

    Google Scholar 

  • Goodpasture E (1919) The significance of certain pulmonary lesion in relation to the ethiology of influenza. Am J Med Sci 158:863–870

    Google Scholar 

  • Gordon D, Cohen RJ, Kelley D, Akselrod S, Shannon DC (1984) Sudden infant death syndrome: abnormalities in short term fluctuations in heart rate and respiratory activity. Pediatric Res 18:921–926

    Google Scholar 

  • Gormsen H, Rosendahl K (1956) Sudden and unexpected infant death. III. Bacteriological and histological examinations in 50 consecutive cases. Acta Med Leg Soc (Liege) 9:161–171

    Google Scholar 

  • Gsell O (1936) Grippepneumonien. Münch Med Wochenschr 21:843–847

    Google Scholar 

  • Gsell O (1932) Die Grippe. Erkrankungen in den Jahren 1920–1932. Erg Ges Med (Berl) 17:455–500

    Google Scholar 

  • Hall CB, Kopelman AE, Douglas RG jr, Geimann JM, Meagher MP (1979) Neonatal respiratory syncytial virus infection. N Engl J Med 300:393–396

    Google Scholar 

  • Hall CE, Cooney MK, Fox JP (1973) The Seattle virus watch. IV. Comparative epidemiologic observations of infections with influenza A and B viruses, 1965–1969 in families with young children. Am J Epidemiol 98:365–380

    Google Scholar 

  • Halonen P, Bennich H, Torfason E, Karlsson T, Ziola B, Matikainen M-T, Hjertsson E, Wesslen T (1979) Solid-phase radioimmunoassay of serum immunoglobulin A antibodies to respiratory syncytial virus and adenovirus. J Clin Microbiol 10:192–197

    Google Scholar 

  • Hamman L (1934) Sudden death. Bull Hopkins Hosp 55:387–415

    Google Scholar 

  • Hartl F, Rembold F (1953) Beobachtungen zur Grippeepedemie (1953) in München. Münch Med Wochenschr 100:987–988

    Google Scholar 

  • Hayslett J, McCarroll J, Brady E, Deuschle K, McDermott W, Kilbourne ED (1962) Endemic influenza. I. Serologic evidence of continuing and subclinical infection in disparate populations in the post-epidemic period. Am Rev Respir Dis 85:1–8

    Google Scholar 

  • Hedinger C (1982) Autopsien — wertvoll oder entbehrlich? Schweiz Med Wochenschr 112:70–75

    Google Scholar 

  • Hennessy AV (1962) Prevention of influenza by vaccination in infants and children. Q Rev Pediatr 17:91–94

    Google Scholar 

  • Hennessy AV (1974) From the National Institutes of Health: Influenza vaccines; summary of influenza workshop. V. Target populations for vaccination. J Infect Dis 129:755–758

    Google Scholar 

  • Hers J, Mulder J (1961) Broad aspects of the pathology and pathogenesis of human influenza. Am Rev Respir Dis [Suppl] 83:84–97

    Google Scholar 

  • Hildebrandt HM, Maassab HF, Willis PW (1962) Influenza virus pericarditis. Am J Dis Child 104:179–182

    Google Scholar 

  • Himmelweit F (1943) Influenza Virus B, isolated from a fatal case of pneumonia. Lancet II:793–794

    Google Scholar 

  • Hochrein M, Schleicher I (1968) Obduktion und internistische Begutachtung. Münch Med Wochenschr 17:1093–1099

    Google Scholar 

  • Holzel A, Parker L, Patterson WH, Cartmel D, White LLR, Purdy R, Thompson KM, Tobin JO'H (1965) Virus isolations from throats of children admitted to Hospital with respiratory and other diseases, Manchester 1962–64. Br Med J [Clin Res] 1:614–619

    Google Scholar 

  • Höring FO (1958) Zur Klinik der Influenzaerkrankungen 1957. In: Abhandlungen aus dem Bundesgesundheitsamt. Zur Grippe-Pandemie 1957. Springer, Göttingen Heidelberg, S 3–5

    Google Scholar 

  • Ilbäck NG, Friman G, Beisel WR, Johnson AJ, Berendt RF (1984) Modifying effects of exercise on clinical course and biochemical response of the myocardium in influenza and tularemia in mice. Infect Immunity 45:498–504

    Google Scholar 

  • Janssen W, Naeve W (1975) Der plötzliche Tod aus natürlicher Ursache. In: Müller B (Hrsg) Gerichtliche Medizin. Springer, Berlin Heidelberg New York, Bd 1, 2. Aufl, S 248–304

    Google Scholar 

  • Jao RL, Wheelock EF, Jackson GG (1970) Production of interferon in volunteers infected with Asian influenza. J Infect Dis 121:419–426

    Google Scholar 

  • Jordan WS, Badger GF, Dingle JH (1958) A study of illness in a group of Cleveland families. XVI. The epidemiology of influenza, 1948–1953. Am J Hyg 68:169–189

    Google Scholar 

  • Julkunen I, Phyälä R, Hovi T (1985) Enzyme immunoassay complement fixation and hemagglutination inhibition tests in the diagnosis of influenza A and B virus infections. Purified hemagglutinin in subtype-specific diagnosis. J Virol Methods 10:75–84

    Google Scholar 

  • Justin-Besançon L, Chrétien J, Delavierre Ph, Péquignot H, Laroche C, Lamotte M, Cornet A, Lamotte-Barrillon S, Grivaux M, Nenna A, Etienne JP, Guerre J (1964) Intérêt clinique des autopsies systématiques en milieu hôspitalier. Sem Hop Paris 40:531–534

    Google Scholar 

  • Kaye D, Rosenbluth M, Hook EW, Kilborne ED (1961) Endemic influenza. Am Rev Respir Dis 85:9–21

    Google Scholar 

  • Kelly DH, Shannon DC (1982) Sudden infant death syndrome and near sudden infant death syndrome: a review of the literature, 1964–1982. Pediatr Clin North Am 29:1241–1261

    Google Scholar 

  • Kilbourne ED (1961) Influenza — The cryptic killer. Am Rev Dis 265–266

  • Kilbourne ED (1975) Epidemiology of influenza. In: Kilbourne ED (ed) The influenza viruses and influenza. Academic Press, New York, pp 483–538

    Google Scholar 

  • Kimball AM, Foy HM, Cooney JD, Allan ID, Matlock M, Plorde JJ (1983) Isolation od respiratory syncytial and influenza viruses from the sputum of patients hospitalized with pneumonia. I Infect Dis 147:181–184

    Google Scholar 

  • Knight V, Fedson D, Baldini J, Douglas RG, Couch RB (1970) Amantadine therapy of epidemic influenza A2 (Hong Kong). Infect Immunity 1:200–204

    Google Scholar 

  • Krech U (1980) Möglichkeiten der Schnelldiagnostik. In: Spiess H, Deinhardt F, Haas R (Hrsg) Virusdiagnostik für Klinik und Praxis, Tggs Bericht Dtsch Vereinigung zur Bekämpfung der Viruskrankheiten. Dtsch Grünes Kreuz Marburg

    Google Scholar 

  • Louria D, Blumenfeld H, Ellis J, Kilbourne E, Rogers D (1959) Studies on influenza in the pandemic of 1957–1958. II. Pulmonary complications of influenza. J Clin Invest 38:213–265

    Google Scholar 

  • Lyon E (1957) Viruskrankheiten und Hyperergie. Allergie und Asthma 3:229–235

    Google Scholar 

  • Maresch W (1960) Zur Ätiologie der plötzlichen Todesfälle im Säuglingsalter. Z Kinderheilk 84:565–575

    Google Scholar 

  • Marshall TK (1970) The Northern Ireland Study: Pathology findings. In: Bergmann AB, Beckwith JD, Ray CG (eds) Sudden infant death syndrome. University of Washington Press, Seattle London, pp 108–117

    Google Scholar 

  • Maxwell ES, Ward TG, van Metre TE (1949) The relation of influenza virus and bacteria in the ethiology of pneumonia. J Clin Invest 28:307–318

    Google Scholar 

  • Mertens T, Eis A-M, Blume C, Oehmichen M (1985) Virusisolierungsversuche bei Kindern nach plötzlichem Kindstod (SIDS). Zentralbl Rechtsmedizin 27:877 (3285)

    Google Scholar 

  • Meurman O (1983) Detection of antiviral IgM antibodies and its problems — a review. Curr Top Microbiol Immunol 104:101–131

    Google Scholar 

  • Mojzes L, Földes V (1982) Gerichtsmedizinische Untersuchung von plötzlichen Todesfällen nach Influenza Infektionen. Proceedings XII. Kongreß der Internationalen Akademie für Gerichtliche und Soziale Medizin. Egermann, Wien, 2 Bd, pp 957–960

    Google Scholar 

  • Mojzes L, Földes V (1985) Plötzlicher Tod infolge Influenza-Infektion. In: Walther G, Haffner HT (Hrsg) Festschrift für Horst Leithoff. Kriminalistik, Heidelberg. S 45–55

    Google Scholar 

  • Molz G, Hartmann HP (1983) Plötzlicher Tod im ersten Lebensjahr. Gegenwärtiger Stand der Kenntnisse. Ein Überblick für den Praktiker. Schweiz Rundschau Med (Praxis) 72:1451–1453

    Google Scholar 

  • Moritz AR, Zamchek N (1946) Sudden and unexpected deaths of young soldiers. Arch Pathol 42:459–494

    Google Scholar 

  • Mulder J, Verdonk GJ (1949) Studies on the pathogenesis of a case of influenza-A pneumonia of three days duration. J Pathol Bacteriol 61:55–61

    Google Scholar 

  • Müller G (1963) Der plötzliche Kindstod. Pathologische Anatomie und Dynamik. Thieme, Stuttgart

    Google Scholar 

  • Müller G (1964) Zur Morphologie der akuten hyperpyretischen Toxikose des älteren Säuglings. Dtsch Med Wochenschr 89:1828–1831

    Google Scholar 

  • Müller H, Veith E (1957) Grippe und Grippetod 1957. Med Klin 52:1901–1905

    Google Scholar 

  • Münch O (1959) Zur Virusgrippe. Pathologische, virologische, serologische und bakteriologische Befunde über 8 Jahre. Z Gesamte Inn Med 14:609–621

    Google Scholar 

  • Murphy BR, Nelson DL, Wright PF, Turney EL, Phelan MA, Channock RM (1982) Secretory and systemic immunological response in children infected with live attenuated influenza A virus vaccines. Infect Immun 36:1102–1108

    Google Scholar 

  • Nelson KE, Greenberg MA, Mufson MA, Moses VK (1975) The sudden infant death syndrome and epidemic viral disease. Am J Epidemiol 101:423–430

    Google Scholar 

  • Ogra PL (1974) From the National Institutes of Health: Influenza vaccines; summary of influenza workshop. V. Target populations for vaccination. J Infect Dis 129:755–758

    Google Scholar 

  • Oldershausen H-F v, Marsch W (1959) Zum klinischen Bild der Grippe-Epidemie 1957/58. (Unter besonderer Berücksichtigung der Komplikationen am Respirationstrakt.) Z Klin Med 156:169–198

    Google Scholar 

  • Parker F, Jolliffe LS, Barnes MW, Finland M (1946) Pathologic findings in the lungs of five cases from which influenza virus was isolated. Am J Pathol 22:797–819

    Google Scholar 

  • Peterson DR, van Belle G, Chinn NM (1979) Epidemiologic comparisons of the sudden infant death syndrome with other major components of infant mortality. Am J Epidemiol 110:699–707

    Google Scholar 

  • Public Health Laboratory Service (1958) Death from Asian influenza, 1957. Br Med J 1:915–919

    Google Scholar 

  • Raettig H (1958) Epidemiologie der Influenza 1957 in Mitteleuropa. In: Abhandlungen aus dem Bundesgesundheitsamt: Zur Grippepidemie 1957. Springer, Berlin Göttingen Heidelberg, S 31–38

    Google Scholar 

  • Ray CG (1970) The role of viruses in sudden infant death syndrome. In: Bergmann AB, Beckwith JB, Ray CG (eds) Sudden infant death syndrome. University of Washington Press, Seattle London, pp 145–155

    Google Scholar 

  • Risse M, Weiler G (1984) Histologische Schilddrüsenbefunde beim Neugeborenen und Säugling unter besonderer Berücksichtigung des plötzlichen Säuglingstodes. Z Rechtsmedizin 92:205–213

    Google Scholar 

  • Risse M, Weiler G, Benker G (1986) Vergleichende histologische und hormonelle Untersuchungen der Schilddrüse unter besonderer Berücksichtigung des plötzlichen Kindstodes (SIDS). Z Rechtsmed 96:31–38

    Google Scholar 

  • Sandritter W (1979) Pathologische Anatomie im „Abseits“? Ther Gegenw 118, Heft 7

  • Saternus KS, Staak M (1984) Plötzlicher Todesfall in der ärztlichen Praxis. Dtsch Med Wochenschr 109:893–898

    Google Scholar 

  • Schäfer HE (1981) Virus und Respirationssystem. Morphogenetische Aspekte pulmonaler Veränderungen. Verh Dtsch Ges Pathologie 65. Tagung. Fischer, Stuttgart New York, S 107–127

    Google Scholar 

  • Schleyer F (1965) Über unerwartete Todesfälle ohne morphologischen Obduktionsbefund. Med Klin 60:1225–1229

    Google Scholar 

  • Schmidt J, Herrmann H (1978) Orthomyxoviren. In: Wildführ G, Wildführ W (Hrsg) Medizinische Mikrobiologie, Immunologie und Epidemiologie. Thieme, Leipzig, Bd II, S 1624–1649

    Google Scholar 

  • Scott DJ, Gardner PS, McQuillin J, Stanton AN, Downham MAPS (1978) Respiratory viruses and cot death. Br Med J 2:12–13

    Google Scholar 

  • Seto DSY, Carver DH (1978) Circulating interferon in sudden infant death syndrome. Proc Soc Exp Biol Med 157:378–380

    Google Scholar 

  • Shannon DC, Kelly DH (1982) SIDSS and near-SIDS (two parts). N Engl J Med 306:959–965; 1023–1028

    Google Scholar 

  • Shope RE, Francis T (1936) The susceptibility of swine to the virus of human influenza. J Exp Med 64:791–801

    Google Scholar 

  • Silber EN (1958) Respiratory viruses and heart disease. Ann Intern Med 48:228–241

    Google Scholar 

  • deSilva L, Khan M, Kampfner G, Tobin J, Gilett R, Morris C (1973) The post mortem diagnosis of influenza infection by fluorescent IgG, IgA and IgM antibody studies of necropsy blood. J Hyg Camb 71:107–112

    Google Scholar 

  • Slepushkin AN (1973) From the national institutes of health: Epidemiologic of influenza — Summary of influenza workshop IV. J Infect Dis 128:361–386

    Google Scholar 

  • Smith TF, Burgert WR, Noble GR, Campbell RF, Van Scoy RE (1976) Isolation of swine influenza virus from autopsy tissue of man. N Engl J Med 294:708–710

    Google Scholar 

  • Spann W (1959) Der plötzliche Tod aus natürlicher Ursache im Säuglings-und Kleinkindesalter. Münch Med Wochenschr 21:929–933

    Google Scholar 

  • Spencer H (1985) Pathology of the lung. Pergamon Press, Oxford New York Toronto Sydney Paris Frankfurt, 4th ed, Vol 1, pp 223–230

    Google Scholar 

  • Stanton AN (1984) Overheating and cot death. Lancet I:1199–1201

    Google Scholar 

  • Stellungnahme der Deutschen Vereinigung zur Bekämpfung der Viruskrankheiten e.V. und des Bundesgesundheitsamtes zur Influenza-Schutzimpfung für die Saison 1982/83 (1982) BGBl 25:287

  • Stickl H (1960) Die Herzbeteiligung bei Grippe. Experimentelle Studien über die Entstehung morphologischer Veränderungen des Myokards bei Grippe. Z Kinderheilk 84:1–17

    Google Scholar 

  • Straub M, Mulder J (1948) Epithelial lesions in the respiratory tract in human influenzal pneumonia. J Pathol Bacteriol 60:429–434

    Google Scholar 

  • Stuart-Harris CH, Schild GC (eds) Influenza. The viruses and the disease. Arnold, London

  • Svehag S-E, Mandel B (1964) The formation and properties of poliovirus neutralizing antibody. J Exp Med 119:1–19, 21–39

    Google Scholar 

  • Sweet C, Smith H (1980) Pathogenicity of influenza virus. Microbiol Rev 44:303–330

    Google Scholar 

  • Thompson RG (1984) Hyperventilation, hypokalemia, and SIDS. Hosp Pract 19:84E-84II

    Google Scholar 

  • Uhr JW, Finkelstein MS (1963) Antibody formation. IV. Formation of rapidly and slowly sedimenting antibodies and immunological memory to bacteriophage. J Exp Med 117:457–477

    Google Scholar 

  • U.S. Department of Health and Human Services (1984) Recommendation of the immunization, practices advisory committee (ACIP): Prevention and control of influenza. Centers for disease control. Morbidity and Mortality Weekly Report 33:253–258

  • Uren EC, Williams AL, Jack I, Rees JW (1980) Association of respiratory virus infections with sudden infant death syndrome. Med J Aust 1:417–419

    Google Scholar 

  • Urquhart GED (1974) Serum IgM and IgA responses in influenza A infections. J Clin Pathol 27:198–201

    Google Scholar 

  • Valdes-Dapena MA (1967) Sudden and unexpected death in infancy: a review of the world literature 1954–1966. Pediatrics 39:123–138

    Google Scholar 

  • Valdes-Dapena MA (1980) Sudden infant death syndrome. A review of the medical literature 1974–1979. Pediatrics 66:597–614

    Google Scholar 

  • Valdes-Dapena MA (1986) Sudden infant death syndrome. Morphology update for forensic pathologists — 1985. Forens Sci Intern 30:177–186

    Google Scholar 

  • Vivell O (1971) Der unerwartete plötzliche Tod im Kindesalter. Rundtischgespräch. Verh Dtsch Ges Pathol 55:537–565

    Google Scholar 

  • Walsh JJ, Dietlein LF, Low FN, Burch GE, Mogabgab WJ (1961) Bronchothrachial response in human influenza type A, asian strain, as studied by light and electron microscopic examination of bronchoscopic biopsies. Arch Intern Med 108:376–388

    Google Scholar 

  • Weinberg SB, Purdy BA (1970) Postmortem leucocyte culture studies in sudden infant death. Nature 226:1264–1265

    Google Scholar 

  • Werne J, Garrow I (1953) Sudden apparently unexplained death during infancy. Am J Pathol 29:633–675

    Google Scholar 

  • Weyrich G (1933) Erfahrungen über den plötzlichen Tod aus innerer Ursache bei Kindern und Jugendlichen. Dtsch Z Gesamte Gerichtl Med 22:116–149

    Google Scholar 

  • Williams AL, Uren EC, Bretherton L (1984) Respiratory viruses and sudden infant death. Br Med J 288:1491–1493

    Google Scholar 

  • Wingfield WL, Pollack D, Grunert RR (1969 Therapeutic efficiency of amantadine HCL and rimantadine HCL in naturally occurring influenza A2 respiratory illness in man. N Engl J Med 281:579–584

    Google Scholar 

  • Wilske J (1984) Der plötzliche Säuglingstod. Morphologische Abgrenzung, Pathomechanismus und Folgerungen für die Praxis. Springer, Berlin Heidelberg New York Toronto

    Google Scholar 

  • Winternitz M, Wason I, McNamara F (1920) The pathology of influenza. Yale University Press, New Haven

    Google Scholar 

  • Zink P, Drescher J, Verhagen W, Flik J, Milbradt H (1986) Serological evidence of recent influenza virus A (H3N2) infections in forensic cases of sudden infant death syndrome (SIDS). Arch Virol (im Druck)

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  1. Gerichtlich-medizinisches Institut der Universität Bern, Bühlstraße 20, CH-3012, Bern, Schweiz

    P. Zink

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Erweiterte Fassung von Vorträgen bei der 62. Jahrestagung der Deutschen Gesellschaft für Rechtsmedizin in Lübeck (1983) und den Arbeitstagungen süddeutscher Gerichtsmediziner in Lausanne (1983) und Warmbad Villach (1985)

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Zink, P. Pathologisch-anatomische befunde bei plötzlichem, unerwartetem tod von kindern und erwachsenen mit influenza-A-infektion. Z Rechtsmed 97, 165–184 (1986). https://doi.org/10.1007/BF00201239

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