Abstract
There are several different strategies to control the timing of a stimulus with respect to the ongoing discharge during the recording of neuronal stimulus-response characteristics. One possible strategy consists of delivering stimuli in such a way that a constant pre-stimulus spike density is reached. Another strategy enforces spike application with a constant stimulus latency after a spontaneous discharge. In this paper the sensitivity of these different strategies for statistical verification of small excitatory response components was investigated. It was found that the difference between observed poststimulus spike distribution and expected spike distribution under the null hypothesis of no stimulus effect was larger using a constant-stimulus-latency (CSL) strategy with an appropriate value for the stimulus latency. Thus, the statistical verification of neuronal response components is clearly facilitated if a CSL strategy is used. This superiority of the CSL strategy is marked, especially for small excitations at neurons discharging slowly with low discharge variability.
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Awiszus, F. Sensitivity of different stimulus-timing strategies for the detection of small excitations in noisy spike train data. Biol. Cybern. 68, 553–558 (1993). https://doi.org/10.1007/BF00200815
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DOI: https://doi.org/10.1007/BF00200815