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Tödliche vergiftung mit protriptylin und haloperidol nach extremer überdosierung

Lethal toxification with protriptyline and haloperidol after massive overdose

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Summary

In this paper the authors report on a case of lethal suicidal toxification with protriptyline and haloperidol after oral ingestion. Gas chromatographic and radioimmunologic investigations were used for quantitative determination of protriptyline and haloperidol in blood, urine, and tissues. The highest concentrations were found in lung and liver. These concentrations are discussed with reference to the cause of death.

Zusammenfassung

Bericht über eine tödliche suizidale Vergiftung mit Protriptylin und Haloperidol nach oraler Aufnahme. Durch gaschromatographische und radioimmunologische Untersuchungen konnten die Wirkstoffe in Organen und Körperflüssigkeiten quantitativ nachgewiesen werden. Die höchsten Konzentrationen fanden sich in Lunge und Leber. Ihre Bedeutung für den Todeseintritt wird diskutiert.

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Literaturverzeichnis

  1. Aderjan R (1981) Tödliche Vergiftungen mit Herzglykosiden. Habil.-Schrift Universität Heidelberg

  2. Ayd FJ jr (1972) Haloperidol: Fifteen years of clinical experience. Dis Nerv Syst 43:459–469

    Google Scholar 

  3. Baden MM, Blaustein A, Ferraro LR, Goessel EA, Herman M, Sommers SC, Stein AA, Weinberg S, Zaino E, Sundram CJ, Harris IJ, Shapiro M (1981) Sudden death after haloperidol. Can Soc For Sci 14:70–72

    Google Scholar 

  4. Baselt RC (1978) Disposition of toxic drugs and chemicals in man, Bd II. Biomedical Publications, Canton

    Google Scholar 

  5. Biggs JT, Ziegler VE (1977) Protriptyline plasma levels and antidepressant response. Clin Pharmacol Ther 22:269–273

    Google Scholar 

  6. Breyer U, Remmer H (1971) Bestimmung von Amitriptylin und Metaboliten in verschiedenen Organen nach einer tödlichen Vergiftung. Arch Toxikol 28:176–181

    Google Scholar 

  7. Charalampous KD, Johnson PC (1967) Studies of C-14-protriptyline in man: Plasma levels and excretion. J Clin Pharmacol 7:93–96

    Google Scholar 

  8. Gaultieri CT, Powell SF (1978) Psychoactive drug interactions. J Clin Psychiatry 39:720–729

    Google Scholar 

  9. Gottschalk LA, Cravey RH (1980) Toxicological and pathological studies on psychoactive drug-involved deaths. Biomedical Publications, Davis

    Google Scholar 

  10. Hebb JH jr, Caplan YH, Crooks CR, Mergner WJ (1982) Blood and tissue concentrations of tricyclic antidepressant drugs in post mortem cases: literature survey and a study of forty deaths. J Anal Toxicol 6:209–216

    Google Scholar 

  11. Hollister LE (1966) Overdoses of psychotherapeutic drugs. Clin Pharmacol Ther 7:142–146

    Google Scholar 

  12. Lewis AJ (1981) Modern drug encyclopedia and therapeutic index. York Medical Books, New York

    Google Scholar 

  13. Linnoila M, George L, Guthrie S (1982) Interaction between antidepressants and perphenazine in psychiatric inpatients. Am J Psychiatry 139:1329–1331

    Google Scholar 

  14. Ketai R, Matthews J, Mozden JJ (1979) Sudden death in a patient taking haloperidol. Am J Psychiatry 136:112–113

    Google Scholar 

  15. Moody JP, Whyte SG, MacDonald AJ (1977) Pharmacokinetic aspects of protriptyline plasma levels. Eur J Clin Pharmacol 11:51–56

    Google Scholar 

  16. Nies A, Robinson DS, Friedman MJ (1977) Relationship between age and tricyclic anti-depressant plasma levels. Am J Psychiatry 134:790–793

    Google Scholar 

  17. Robinson AE, Coffer AI, McDowall RD (1974) Toxicology of some autopsy cases involving tricyclic antidepressant drugs. Z Rechtsmed 74:261–266

    Google Scholar 

  18. Schlicht HJ, Gelbke HP (1978) A micromethod for the isolation of drugs from blood using Amberlite XAD-2. Z Rechtsmed 81:25–30

    Google Scholar 

  19. Smith RC, Crayton J, Dekirmenjian H, Klass D, Davis JM (1979) Blood levels of neuroleptic drugs in nonresponding chronic schizophrenic patients. Arch Gen Psychiatry 36:579–584

    Google Scholar 

  20. Späth G (1982) Vergiftungen und akute Arzneimittelüberdosierungen. de Gruyter, Berlin New York, S 256–274

    Google Scholar 

  21. Ziegler VE, Biggs JT, Wylie LT, Coryell WH, Hanifl KM, Hawf DJ, Rosen SH (1978) Protriptyline kinetics. Clin Pharmacol Ther 23:580–584

    Google Scholar 

  22. White SJ, MacDonald AJ, Naylor GJ, Moody JP (1976) Concentrations of protriptyline and clinical effects in depressed women. Br J Psychiatry 128:384–390

    Google Scholar 

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Authors and Affiliations

  1. Institut für Rechtsmedizin der Universität Heidelberg, Voßstraße 2, D-6900, Heidelberg, Bundesrepublik Deutschland

    G. Fechner, I. Magureanu, R. Aderjan & Gg. Schmidt

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  1. G. Fechner
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  2. I. Magureanu
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  3. R. Aderjan
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  4. Gg. Schmidt
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Fechner, G., Magureanu, I., Aderjan, R. et al. Tödliche vergiftung mit protriptylin und haloperidol nach extremer überdosierung. Z Rechtsmed 97, 277–283 (1986). https://doi.org/10.1007/BF00200607

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  • DOI: https://doi.org/10.1007/BF00200607

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