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Properdin factor B (Bf) polymorphism in the population of veneto, Italy

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Summary

The distribution of Bf phenotypes in the population of Veneto was investigated by agarose gel electrophoresis and immunofixation. In our sample (n=592), the seven common phenotypes F, S, F-S, S-S0.7, S-F1, F-S0.7, F-F1 were observed and the following gene frequencies calculated: Bf*S=0.7399; Bf*F=0.2280; Bf*F1=0.0177; Bf*S0.7=0.0144. These gene frequencies are compared to those found in other populations. Analysis of 21 mother-child pairs was in agreement with an autosomal codominant inheritance.

Zusammenfassung

Die Verteilung der Bf-Phänotypen wurde bei der venetischen Bevölkerung mittels Agarosegel-Elektrophorese und Immunofixation untersucht. In unseren Stichproben wurden die Bf-Phänotypen F, S, F-S, S-S0,7, S-F1, F-S0,7, F-F1 beobachtet und folgende Genfrequenzen berechnet: Bf*S=0,7399; Bf*F=0,2280; Bf*F1=0,0177; Bf*S0,7=0,0144. Diese Genfrequenzen wurden mit den bei anderen Bevölkerungsgruppen gefundenen Frequenzen verglichen. Die Untersuchung von 21 Mutter-Kind-Paaren zeigte eine autosomal-kodominante Relation.

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References

  1. Alper CA, Boenish T, Watson L (1972) Genetic polymorphism in human glycin-rich-beta-glycoprotein. J Exp Med 135:68–80

    Google Scholar 

  2. Mauff G, Hauptmann G, Hitzeroth HW, Gauchel F, Scherz R (1978) The nomenclature of Properdin factor B allotypes. Z Immunforsch 154:115–120

    Google Scholar 

  3. Weidinger S, Schwarzfischer E, Cleve H (1979) Properdin factor B-polymorphism: An indication for the existence of a Bfo allele. Z Rechtsmed 83:259–264

    Google Scholar 

  4. Sucin-Foca N, O'Neil G, Rubinstein P (1980) Evidence for the existence of possible Bf “null” allele. In: Terasaki PI (ed) Histocompatibility testing. UCLA Tissue Typing Laboratory, Los Angeles, pp 935–936

    Google Scholar 

  5. Tokunaga K, Omoto K, Yukiyama Y, Sakurai M, Saji H, Maruy E (1984) Further study on a Bf silent allele. Hum Genet 67:449–451

    Google Scholar 

  6. Bertrams J, Mauff G (1985) Another family with a silent allele of properdin factor B polymorphism (Bf*Q0). Hum Genet 70:321–323

    Google Scholar 

  7. Dykes DD, Polesky HF (1978) Application of tests for serum proteins and red cell enzymes in determination of parentage. In: Silver ASCP (ed) Paternity testing, pp 35–54

  8. Dykes DD, Polesky HF (1980) Properdin factor B (Bf) as an exclusion determinate in parentage testing. Hum Hered 30:286–290

    Google Scholar 

  9. Domenici R, Giari A, Bargagna M (1986) Distribution of Bf and C3 types in Tuscany. Adv Forens Haemogenet 1:268–271

    Google Scholar 

  10. Malavasi F, Olivetti E, Milanese C, Carbonara AO (1981) Properdin factor B polymorphism in continental Italy and Sardinia. Hum Genet 58:209–212

    Google Scholar 

  11. Davrinche C, Charlionet R, Rivat C, Sesbone R, Bayorek M, Arnone M (1984) Genetic variants of human B component (Bf system) and alpha-1-antitrypsin (PI system) in a population from Sardinia. Hum Hered 34:297–302

    Google Scholar 

  12. Hjalmarsson P (1981) Properdin factor B (Bf) polymorphism in Sweden. Referate 9. Internationale Tagung der Gesellschaft für forensische Blutgruppenkunde, Bern, S 89

  13. Teisberg P, Olaisen B (1977) Properdin factor B (Bf) polymorphism in Norway. Vox Sang 32:52–55

    Google Scholar 

  14. Scherz R, Pflugshaupt R, Bütler R (1977) Genetic polymorphism of glycine-rich beta-glycoprotein in the Swiss and Italian populations. Hum Hered 27:143–146

    Google Scholar 

  15. Mauff G, Hummel K, Pulverer G (1975) Properdin factor B (glycine-rich beta-glycoprotein or C3 proactivator) polymorphism: Genetic and biochemical aspects. First application to paternity cases. Z Immunforsch 150:327–338

    Google Scholar 

  16. Kühnl P, Spielman W (1978) Properdin factor B-polymorphism in the population of Hessen, Germany. Z Rechtsmed 81:125–131

    Google Scholar 

  17. Dykes DD, Polesky HF, Crawford MH (1981) Properdin factor B (Bf) distribution in North and Central American populations. Electrophoresis 2:320–323

    Google Scholar 

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Authors and Affiliations

  1. Istituto di Medicina Legale dell'Università, Via Falloppio 50, Padova, Italy

    C. Crestani, L. Caenazzo, P. Cortivo, C. Scorretti & C. Caenazzo

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  1. C. Crestani
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  2. L. Caenazzo
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  3. P. Cortivo
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  4. C. Scorretti
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  5. C. Caenazzo
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Financially supported by the Ministry of Education of Italy

The results were partially communicated at the 12th International Congress of the Society of Forensic Haemogenetics, Vienna 1987

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Crestani, C., Caenazzo, L., Cortivo, P. et al. Properdin factor B (Bf) polymorphism in the population of veneto, Italy. Z Rechtsmed 101, 81–85 (1988). https://doi.org/10.1007/BF00200289

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  • DOI: https://doi.org/10.1007/BF00200289

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