Summary
A synergistic activity of BCG on the mitogen stimulation of mouse and human lymphocytes could be demonstrated. In this test BCG vaccines produced in a homogeneously dispersed culture proved to be more potent than vaccines which were grown as a surface pellicle and homogenized in a ball mill. Both B- and T-cell activation were enhanced by the addition of BCG. The possible mechanism and the implications of these observations for the use of BCG as an immunostimulating agent in the treatment of cancer patients are discussed.
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Bruynzeel, D.P., Ettekoven, H. & Kreeftenberg, J.G. The synergistic activity of BCG on the stimulation of lymphocytes with concanavalin A and lipopolysaccharide. Cancer Immunol Immunother 3, 253–258 (1978). https://doi.org/10.1007/BF00200079
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DOI: https://doi.org/10.1007/BF00200079