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Non-human primate (baboon) anti-gross cystic disease fluid protein-15 antibody infusion in four women with metastatic breast carcinoma

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Summary

Four women with metastatic breast carcinoma and elevated plasma levels of human breast gross cystic disease fluid protein of 15,000 dalton monomer size (GCDFP-15) were treated IV with non-human primate (baboon) anti-GCDFP-15 antibody. Three patients were given a single IV infusion of antibody, while the fourth patient received four sequential IV infusions. Antibody dosage patients, after antibody infusion the plasma level of GCDFP-15 decreased to 0 ng/ml and remained there as long as “free” circulating anti-GCDFP-15 antibody was present. The plasma half-life of the antibody ranged between 1 and 40 h and the duration of detectable free antibody ranged from 6 to 240 h. No toxicity was observed for the dosage range of antibody tested. No anti-baboon antibody response was detected. In the patient who received four sequential infusions of antibody partial regression of subcutaneous metastatic nodules occurred. The other three patients showed no clinically detectable changes from the antibody infusion.

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Authors and Affiliations

  1. Department of Surgery, Columbia Presbyterian Medical Center, 10032, New York, NY, USA

    Alison Estabrook, Sven J. Kister & Mark A. Hardy

  2. Department of Medicine, Columbia Presbyterian Medical Center, 10032, New York, NY, USA

    Lionel Grossbard & Martin W. Oster

  3. Department of Surgery, New England Deaconess Hospital, Cancer Research Institute, Harvard Medical School, 02215, Boston, MA, USA

    Sarah Davis & Darrow E. Haagensen Jr

  4. Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 02115, Boston, MA, USA

    Gwen Mazoujian

Authors
  1. Alison Estabrook
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  2. Sven J. Kister
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  3. Mark A. Hardy
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  4. Lionel Grossbard
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  5. Martin W. Oster
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  6. Sarah Davis
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  7. Gwen Mazoujian
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  8. Darrow E. Haagensen Jr
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Funded in part by a grant from the William J. Matheson Foundation

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Estabrook, A., Kister, S.J., Hardy, M.A. et al. Non-human primate (baboon) anti-gross cystic disease fluid protein-15 antibody infusion in four women with metastatic breast carcinoma. Cancer Immunol Immunother 23, 143–147 (1986). https://doi.org/10.1007/BF00199821

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  • DOI: https://doi.org/10.1007/BF00199821

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