Cancer Immunology, Immunotherapy

, Volume 19, Issue 2, pp 73–78 | Cite as

Antitumor effect induced by a hot water extract of Chlorella vulgaris (CE): Resistance to meth-A tumor growth mediated by CE-induced polymorphonuclear leukocytes

  • Fumiko Konishi
  • Kuniaki Tanaka
  • Kunisuke Himeno
  • Kazuto Taniguchi
  • Kikuo Nomoto
Original Articles


When a hot water extract of Chlorella vulgaris (CE) was injected into the peritoneal cavity of BALB/c mice inoculated with syngeneic Meth-A tumor cells, the survival times were strikingly prolonged. Furthermore, peritoneal exudate cells (PEC) rich in polymorphonuclear cells (PMN) obtained from normal mice 24 h after CE injection exhibited an antitumor effect in a Winn-type assay using normal recipients. Such an activity of PEC remained almost intact after T cell or macrophage depletion. However, such PEC did not express an antitumor effect in a Winn-type assay using irradiated recipients. It was suggested that CE-induced PEC, presumably PMN, expressed an antitumor effect in cooperation with a host- or recipient-derived element(s) sensitive to irradiation. The anti-tumor mechanism of CE may be different from that of OK-432, one of the biological response modifiers.


Tumor Cell Tumor Growth Survival Time Peritoneal Cavity Antitumor Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Fumiko Konishi
    • 1
  • Kuniaki Tanaka
    • 1
  • Kunisuke Himeno
    • 1
  • Kazuto Taniguchi
    • 1
  • Kikuo Nomoto
    • 1
  1. 1.Department of Immunology, Medical Institute of BioregulationKyushu UniversityFukuokaJapan

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