Summary
Antibody and rejection responses against the Moloney leukemia virus-induced YAC lymphoma of A strain origin were found to be weak in A but high in (A×C57Bl)F1 hybrids. (A×C57Bl) × A backcross mice typed for expression of H-2 antigens were investigated for these responses in order to ascertain the importance of the H-2 phenotype of the host and the development of antibodies for rejection of the tumor cells. With an LD50 challenge inoculum in immunized backcross mice, the presence of anti-YAC antibodies appeared to be important for protection against the outgrowth of the tumor, particularly in the H-2a mice. None of them survived, unless antibody-positive. On the other hand, a proportion of the H-2 heterozygous mice rejected the tumor in the absence of antibodies. In the antibody-positive group a higher number of H-2 heterozygous mice survived than of H-2 homozygous mice. The results showed that both humoral and cellular responses are important for the rejection of an antigenic lymphoma and indicate the contribution of an F1 anti-parental component in the latter.
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Åsjö, B., Klein, E., Fenyö, E.M. et al. The role of humoral immunity and the contribution of the F1 anti-parental effect in the rejection of a moloney leukemia virus-induced lymphoma graft. Cancer Immunol Immunother 15, 92–95 (1983). https://doi.org/10.1007/BF00199697
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DOI: https://doi.org/10.1007/BF00199697