Summary
Spleen lymphocytes from ependymoblastoma hosting mice show specific receptors for isologuous cytoplasmic tumor proteins. Binding demonstrated by immunofluorescence was observed on lymphocytes from mice transplanted either subcutaneously or intracranially with the tumor model. As control, normal brain soluble proteins did not show binding.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Benda, P., Takesuda, M., Sweet, W. H.: Demonstration of an astrocyte-specific cerebroprotein by an immunofluorescence study of human brain tumours. J. Neurosurg. 33, 281 (1970)
Bogoch, S., Sacks, W., Sweet, W. H., Horsch, G., Belval, P. C.: Protides of Biological Fluids. Peters H. (ed.), p. 13. New York: Elsevier 1968
Burnet, F. M.: The concept of immunological surveillance. Prog. exp. Tumour Res. 13, 1 (1970)
Coakham, H.: Surface antigen(s) common to human astrocytoma cells. Nature (Lond.) 250, 328 (1974)
Haglid, K. G., Stavrou, D.: Water soluble and pentanol-extractable proteins in human brain normal tissue and human brain tumours, with special reference to S-100 protein. J. Neurochem. 20, 1523 (1973)
Haskill, J. S., Moore, M. A. S.: Two dimensional cell separation: Comparison of embryonic and adult haemopoietic stem cells. Nature (Lond.) 226, 853 (1970)
Kellen, J. A., Lo, A. C. H.: Demonstration of antibodies against 7,12-dimenthylbenz(a)anthracene-induced rat mammary tumors by immunofluorescence. Oncology 27, 315–323 (1973)
Lo, J. S.: Immunochemical Studies of Experimental Tumours, Ph. D. Thesis, University of Toronto, 1975
Miller, R. G., Phillips, R. A.: Separation of cells by velocity sedimentation. J. cell Physiol. 73, 191 (1969)
Stavrou, D., Haglid, K. G., Weidenbach, W.: The brain specific proteins S-100 and 14.3.2 in experimental brain tumours of the rat. Gesamte Exp. Med. 156, 237 (1971)
Thomas, L.: Cellular and Humoral Aspects of Hypersensitivity States. Lawrence H. S. (ed.), p. 529. New York: Hoeber 1969
Toh, B. H., Cauchi, M. N.: Brain-associated tumour antigens demonstrated by immunofluorescence. Nature (Lond.) 250, 597 (1974)
Zimmerman, H. M.: Brain tumours: Their incidence and classification in man and their experimental production. N.Y. Acad. Sci. 159, 337 (1969)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lo, J.S., Mirakian, A. & Kellen, J.A. Host lymphocytic recognition of cytoplasmatic antigens from an experimental brain tumor. Cancer Immunol Immunother 3, 61–64 (1977). https://doi.org/10.1007/BF00199327
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00199327