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Immunoprophylaxis toward mammary carcinoma in mice immune to Listeria monocytogenes

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Summary

The growth of a transplantable mammary carcinoma in C3H and DBA mice was suppressed in animals immune to Listeria monocytogenes (LM). When tumor cells were mixed with live bacteria at the time of transplantation, experimental LM-immune animals survived a lethal dose of tumor cells. Treatment of non-immune animals with tumor cells plus LM was ineffective. Immunity to LM was therefore a prerequisite of antitumor protection.

The destruction of tumor cells was most likely a nonspecific side effect of the immune reaction to LM, since administration of LM at the same site as tumor cells was necessary. Despite this nonspecific mode of tumor suppression, animals which were protected from progressive tumor growth nevertheless developed specific antitumor immunity, being able to resist a secondary challenge by a lethal dose of syngeneic tumor cells.

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References

  1. Bartlett, G. L., Zbar, B., Rapp, H. J.: Suppression of murine tumor growth by immune reaction to the Bacillus-Calmette-Guerin strain of Mycobacterium bovis. J. Natl. Canc. Inst. 48, 245 (1972)

    Google Scholar 

  2. Bast, Jr. R. C., Zbar, B., Mackaness, G. B., Rapp, H. J.: Antitumor activity of bacterial infection. I. Effect of Listeria monocytogenes on growth of a murine fibrosarcoma. J. Natl. Canc. Inst. 54, 749 (1975)

    Google Scholar 

  3. Gershon, R. K., Carter, R. L., Kondo, K.: On concomitant immunity in tumor-bearing hamsters. Nature 213, 674 (1967)

    Google Scholar 

  4. Hawrylko, E., Mackaness, G. B.: Immunopotentiation with BCG. IV. Factors affecting the magnitude of an antitumor response. J. Natl. Canc. Inst. 51, 1683 (1973)

    Google Scholar 

  5. Hawrylko, E.: Immunopotentiation with BCG: Dimensions of a specific antitumor response. J. Natl. Canc. Inst. 54, 1189 (1975)

    Google Scholar 

  6. Hibbs, J. B., Lambert, L. H., Remington, J. S.: Possible role of macrophage mediated nonspecific cytotoxicity in tumor resistance. Nature New Biol. 235, 48 (1972)

    Google Scholar 

  7. Klein, E.: Tumors of the skin. Immunotherapy of cutaneous and mucosal neoplasms. New York J. Med. 68, 900 (1968)

    Google Scholar 

  8. Krahenbuhl, J. L., Remington, J. S.: The role of activated macrophages in specific and nonspecific cytostasis of tumor cells. J. Immunol. 113, 507 (1974)

    Google Scholar 

  9. Lane, F. C., Unanue, E. R.: Immunologic events during Listeria monocytogenes infection in mice. Adjuvanticity and immunogenicity of macrophage-bound antigens. J. Immunol. 110, 829 (1973)

    Google Scholar 

  10. Leibowitch, J. L., David, J. R.: Lymphocyte-macrophage interaction in resistance to Listeria monocytogenes. Ann. Imm. (Inst. Past.) 124C, 441 (1973)

    Google Scholar 

  11. Mackaness, G. B.: The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J. Exp. Med. 129, 973 (1969)

    Google Scholar 

  12. Mackaness, G. B., Blanden, R. V.: Cellular immunity. Progr. Allergy 11, 89 (1967)

    Google Scholar 

  13. Mackaness, G. B., Auclair, D. J., Langrange, P. H.: Immunopotentiation with BCG. I. Immune response to different strains and preparations. J. Natl. Canc. Inst. 51, 1655 (1973)

    Google Scholar 

  14. Yashphe, D. J.: Immunological factors in nonspecific stimulation of host resistance to syngeneic tumors. A review. Isr. J. Med. Sci. 7, 90 (1971)

    Google Scholar 

  15. Youdim, S.: Resistance to tumor growth mediated by Listeria monocytogenes. Destruction of experimental malignant melanoma by LM-activated peritoneal and lymphoid cells. J. Immunol. 116, 579 (1976)

    Google Scholar 

  16. Youdim, S., Moser, M., Stutman, O.: Nonspecific suppression of tumor growth by an immune reaction to Listeria monocytogenes. J. Natl. Canc. Inst. 52, 193 (1974)

    Google Scholar 

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Authors and Affiliations

  1. Division of Clinical Immunology and Allergy, and the McGill University Medical Clinic of the Montreal General Hospital Research Institute, Montreal, Quebec, Canada

    M. Buckspan, S. Hojvat & E. Skamene

Authors
  1. M. Buckspan
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  2. S. Hojvat
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  3. E. Skamene
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Additional information

Present address: Department of Surgery (Urology), Mount Sinai Hospital, Toronto, Ontario, Canada. Dr. Buckspan was the recipient of an Irving Howard Cameron Memorial Scholarship

Recipient of the Monat Award from McGill University

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Buckspan, M., Hojvat, S. & Skamene, E. Immunoprophylaxis toward mammary carcinoma in mice immune to Listeria monocytogenes . Cancer Immunol Immunother 3, 49–56 (1977). https://doi.org/10.1007/BF00199325

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  • DOI: https://doi.org/10.1007/BF00199325

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