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Enhancement of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCMC) by an Interphase Material (IPM) extracted from a non-pathogenic strain of mycobacteria

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Summary

Interphase Material (IPM) extracted from M. smegamtis has been previously shown to protect mice against experimental tumors, to activate macrophages as measured by in vitro growth inhibition of neoplastic cells, and to induce nonspecific blast transformation of human lymphocytes and murine B cells.

In the present report IPM was studied to determine its effect on antibody-dependent, cell-mediated cytotoxicity (ADCMC). Our findings demonstrate that IPM strongly enhances the ADCMC of murine spleen cells, even if it is injected 14 or 32 days prior to the cytotoxicity assay. An adherent population of spleen cells was shown to be responsible for this effect.

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Authors and Affiliations

  1. Groupe de Recherche no 31 du Centre National de la Recherche Scientifique, Immunothérapie Expérimentale, Institut Pasteur, 28, rue du Dr. Roux, 75724, Paris, cedex 15, France

    Dominique Juy & Claude Leclerc

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  1. Dominique Juy
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  2. Claude Leclerc
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Juy, D., Leclerc, C. Enhancement of Antibody-Dependent Cell-Mediated Cytotoxicity (ADCMC) by an Interphase Material (IPM) extracted from a non-pathogenic strain of mycobacteria. Cancer Immunol Immunother 3, 23–25 (1977). https://doi.org/10.1007/BF00199321

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  • DOI: https://doi.org/10.1007/BF00199321

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