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Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon


The histamine-2 receptor antagonist cimetidine (10−5 M) and the prostaglandin synthesis inhibitor indomethacin (10−8 M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma. Antibody-dependent cellular cytotoxicity was increased in most melanoma patients but in a lower proportion of patients with colorectal cancer. Compared with the effect of interferon the augmentation of NK- and K-cell activities was small in most patients. Cimetidine was also demonstrated to bring about a further increase in the interferon-induced NK activation of peripheral blood mononuclear cells from a majority of healthy donors and patients with melanoma. Furthermore, cimetidine augmented the interferon-induced K-cell activation of peripheral blood mononuclear cells from most patients with melanoma and colorectal cancer.

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Flodgren, P., Sjögren, H.O. Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon. Cancer Immunol Immunother 19, 28–34 (1985).

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  • Melanoma
  • Colorectal Cancer
  • Natural Killer Cell
  • Peripheral Blood Mononuclear Cell
  • Indomethacin