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Immune responses of DBA/2 mice bearing melanoma tumors: Cell-mediated immune responses after challenge with vaccinia virus

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Summary

Cell-mediated immune responses in DBA/2 mice bearing melanoma tumors (TB-mice) were measured and compared to similar responses in mice without tumors (C-mice). Splenic lymphocytes from TB-mice had a reduced capacity to respond to both B and T-cell mitogens, but TB-mice responded to infection with vaccinia virus by developing a virus-specific cytotoxic T-cell response equal to that measured with splenic effectors prepared from virus-infected C-mice. NK-cell activity, as measured by the in vitro lysis of YAC-1 targets by splenic effectors, was significantly depressed in TB-mice but, after infection of the animals with vaccinia virus, was restored to levels equal to that measured with splenic effectors prepared from C-mice. Doses of vaccinia virus, strain WR which elicited vaccinia-virus-specific cytotoxic T cells or stimulated NK-cell activity, failed to elicit or stimulate cytotoxic effectors specific for S91-melanoma tumor cells.

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Author notes

  1. Jacquelyn A. Byrne

    Present address: Department of Immunopathology, Scripps Clinic & Research Foundation, 92037, La Jolla, CA, USA

  2. M. Soloski

    Present address: Department of Microbiology, University of Texas Health Science Center, Southwestern Medical School, 75235, Dallas, TX, USA

Authors and Affiliations

  1. Department of Microbiology, University of Medicine and Denistry of New Jersey, Rutgers Medical School, 08854, Piscataway, NJ, USA

    Jacquelyn A. Byrne, M. Soloski & J. A. Holowczak

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  1. Jacquelyn A. Byrne
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  2. M. Soloski
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  3. J. A. Holowczak
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Byrne, J.A., Soloski, M. & Holowczak, J.A. Immune responses of DBA/2 mice bearing melanoma tumors: Cell-mediated immune responses after challenge with vaccinia virus. Cancer Immunol Immunother 16, 81–87 (1983). https://doi.org/10.1007/BF00199236

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  • DOI: https://doi.org/10.1007/BF00199236

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