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Immunotherapy with tumor cell subpopulations

II. Therapy of drug-resistant L1210 leukemia and EL4 lymphoma

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Summary

Tumor cell subpopulations were isolated from parental (drug-sensitive) L1210 tumor by lectinnylon chromatography and evaluated in active, specific immunotherapy of a thioguanine-resistant L1210 subline. Cells released by mannoside were effective in causing regression of the variant subline. This effectiveness was not altered by treatment of the subpopulation with neuraminidase. Subpopulations either not binding fucose-specific columns or released from glucose-specific columns were also effective immunogens. Studies using the syngeneic EL4 lymphoma model indicated that mannoside-released cells were effective in combination chemotherapy-immunotherapy. The results further demonstrate the feasibility of this approach to active, specific immunotherapy.

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Author notes

  1. Jerald J. Killion

    Present address: Department of Physiology, Oral Roberts University School of Medicine, 7777 S. Lewis Ave., 74171, Tulsa, Oklahoma, USA

Authors and Affiliations

  1. Cancer Research Program, Oklahoma Medical Research Foundation, USA

    Jerald J. Killion

  2. Department of Radiological Sciences, University of Oklahoma Health Sciences Center, 825 N.E. 13th Street, 73104, Oklahoma City, Oklahoma, USA

    Jerald J. Killion

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  1. Jerald J. Killion
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Killion, J.J. Immunotherapy with tumor cell subpopulations. Cancer Immunol Immunother 5, 21–26 (1978). https://doi.org/10.1007/BF00199203

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  • DOI: https://doi.org/10.1007/BF00199203

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