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Radiation-resistance of the local tumor rejection response

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Summary

The effect of single -dose local treatment with 400 to 1600 rad of gamma irradiation on the growth of syngeneic mammary carcinoma (MC) and fibrosarcoma (FS) subcutaneous (SC) implants was investigated in female C3H/He hosts. The mice were prepared so as to present the tumor implant in various stages of growth at the time of irradiation and with the implantation site at various stages of development of the local immune rejection response. With the doses of radiation used, the growth of the tumors was, under all experimental conditions, reduced by irradiation, and the incidences of complete rejection were increased. On the basis of these observations, and supported by histological examinations, it appears that therapeutic doses of small field irradiation are unlikely to compromise a local tumor rejection response.

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Authors and Affiliations

  1. Department of Cancer Therapy Development, Pondville Hospital, 02081, Walpole, Massachusetts, USA

    J. Vaage

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  1. J. Vaage
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Vaage, J. Radiation-resistance of the local tumor rejection response. Cancer Immunol Immunother 5, 17–20 (1978). https://doi.org/10.1007/BF00199202

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  • DOI: https://doi.org/10.1007/BF00199202

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