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Cell-mediated immunity in human acute myeloblastic leukemia

Lymphocyte stimulation by autologous leukemic and nonleukemic myoblasts

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Summary

Lymphocyte stimulation tests with autologous myeloblasts were performed in 31 patients with nonlymphatic acute leukemia. Twenty-five patients were receiving chemotherapy combined with immunotherapy; six received chemotherapy only. Thirteen nonleukemic patients with various disorders and six healthy control patients were also studied.

It was found that 4/15 patients in 9/38 tests had autologous lymphocytes stimulated by autologous circulating myeloblasts. Bone marrow cells also effected stimulation, significantly more often if the marrow was taken in relapse than when it was taken in remission.

However, so-called immunotherapy with allogeneic leukemic myeloblasts and BCG could not be shown to increase these frequencies. Nor did it significantly increase the degree of stimulation measured as DNA synthesis in lymphocytes.

Moreover, nonleukemic bone marrow cells from patients with other disorders also stimulated autologous lymphocytes in 1/13 patients. No recognition of autologous myeloblasts was observed when the responding lymphocytes were taken in incomplete remission or during the month preceding relapse.

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Authors and Affiliations

  1. The Department of Medicine IV, Division of Hematology, Karolinska Sjukhuset, Radiumhemmet, Södersjukhuset, Stockholm

    C. Pauli, F. Vànky, R. Hast, C. Lindemalm, A. M. Udén & P. Reizenstein

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  1. C. Pauli
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  2. F. Vànky
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  3. R. Hast
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  4. C. Lindemalm
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  5. A. M. Udén
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  6. P. Reizenstein
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with the technical assistance of T. Lehtinen and A. M. Sjögren

Supported by the Swedish Cancer Research Foundation Grant no. 699-B76-04XA

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Pauli, C., Vànky, F., Hast, R. et al. Cell-mediated immunity in human acute myeloblastic leukemia. Cancer Immunol Immunother 5, 1–10 (1978). https://doi.org/10.1007/BF00199200

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