Skip to main content
SpringerLink
Log in

Serial immune function testing to predict clinical disease relapse in patients with solid tumors

  • Review
  • Published:
Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Anthony HM, Kirk JA, Madsen KE, Mason MK, Templeman GH (1975) E and EAC rosetting lymphocytes in patients with carcinoma of bronchus. II. A sequential study of thirty patients: Effect of BCG. Clin Exp Immunol 20:41

    Google Scholar 

  2. Berkelhammer J, Mastrangelo MJ, Bellet RE, Prehn RT, Thibaults LH (1978) Failure of lymphocyte microcytotoxicity to distinguish relapsers from non-relapsers in melanoma patients receiving post-surgical adjuvant chemotherapy. Eur J Cancer 14:793

    Google Scholar 

  3. Berkelhammer J, Mastrangelo MJ, Bellet RE, Berd D, Prehn RT (1979) Chemoimmunotherapy increases the lymphocyte reactivity of melanoma patients. Eur J Cancer 15:197

    Google Scholar 

  4. Bolton PM, Mander AM, Davidson JM, James SL, Newcombe RG, Hughes LE (1975) Cellular immunity in cancer: Comparison of delayed hypersensitivity skin tests in three common cancers. Br Med J III:18

    Google Scholar 

  5. Braun DP, Harris JE (1981) Effects of combination chemotherapy on immunoregulatory cells in the peripheral blood of solid tumor cancer patients: Correlation with rebound overshoot immune function recovery. Clin Immunol Immunopathol 20:193

    Google Scholar 

  6. Braun DP, Nisius S, Hollinshead A, Harris JE (1983) Serial immune testing in surgically resected lung cancer patients. Cancer Immunol Immunopathol (in press)

  7. Brooks WH, Latta RB, Mahaley MS, Roszman TL, Dudka L, Skaggs C (1979) Immunobiology of primary intracranial tumors. V. Correlation of lymphocyte index and clinical status. J Neurosurg 54:331

    Google Scholar 

  8. Brosman S, Elhilali M, Vescera C, Fahey J (1979) Immune response in bladder cancer patients. J Urol 121:162

    Google Scholar 

  9. Catalona WJ, Ratliff TL, McCool RS (1979) Concanavalin A-activated suppressor cells in peripheral blood and lymph nodes of urologic cancer patients. Surg Forum 6:21

    Google Scholar 

  10. Cunningham TJ, Daut D, Wolfgang PE, Mellyn M, Maciolek S, Sponzo RW, Horton J (1976) A correlation of DNCB-induced delayed cutaneous hypersensitivity reactions and the course of disease in patients with recurrent breast cancer. Cancer 37:1686

    Google Scholar 

  11. Cummingham MP, Caprini JA, Oviedo MA, Cohen E, Robinson B, Scanlon EF (1980) Immune responses and recurrences in Stage II and III breast cancer patients undergoing adjuvant chemoimmunotherapy. In: Crispen RG (ed) Tumor progression. Elsevier North/Holland, Amsterdam, p 355

    Google Scholar 

  12. Dean JH, Cannon GB, Jerrels TR, McCoy JL, Herberman RB (1980) Sensitive measurement of immunocompetence and antitumor reactivity in lung cancer patients and possible mechanisms of immunosuppression. In: Crispen RG (ed) Neoplasm immunity: Experimental and clinical. Elsevier/North Holland, Amsterdam, p 357

    Google Scholar 

  13. Dellon AC, Potvin C, Chretieu PB (1975) Thumus-dependent lymphocyte levels in bronchogenic carcinoma: Correlations with histology, clinical stage and clinical course after surgical treatment. Cancer 35:687

    Google Scholar 

  14. Eilber FR, Nizze JA, Morton DL (1975) Sequential evaluation of general immune competence in cancer patients: Correlation with clinical course. Cancer 35:660

    Google Scholar 

  15. Engleman EG, Benike CJ, Hoppe RT, Kaplan HS, Berberich FR (1980) Autologous mixed lymphocyte reaction in patients with Hodgkin's disease. J Clin Invest 66:149

    Google Scholar 

  16. Evans CM, Bowen JG (1977) Immunological tests in carcinoma of the prostate. Proc R Soc Med 70:417

    Google Scholar 

  17. Glass U, Wasserman J, Blomgren H, de Schryver A (1976) Lymphopenia and metastatic breast cancer patients with and without radiation therapy. Int J Rad Oncol Biol Phys 1:189

    Google Scholar 

  18. Golub SH, Forsythe AB, Morton DL (1977) Sequential examination of lymphocyte proliferative capacity in patients with malignant melanoma receiving BCG immunotherapy. Int J Cancer 19:18

    Google Scholar 

  19. Gross NJ, Eddie-Quartery AC (1976) Monitoring of immunologic status of patients receiving BCG therapy for malignant disease. Cancer 37:2183–2193

    Google Scholar 

  20. Gross RL (1978) Current status of immunologic studies in human lung cancer. Los Alamos Scientific Laboratory; U.S. Department of Commerce, National Technical Information Service (June)

  21. Hakala TR, Lange PH, Elliott AY, Fraley EE (1976) Changes in cell-mediated cytotoxicity during the clinical course of patients with bladder carcinoma. J Urol 115:268

    Google Scholar 

  22. Harris JE, DeBoer KP, Vahey AL, Braun DP (1982) The measurement of leukocyte subsets in the peripheral blood of solid tumor cancer patients using monoclonal antibody reagents. Med Pediatr Oncol 10:185

    Google Scholar 

  23. Haynes BF, Katz P, Fauci AS (1980) Immune responses of human lymphocytes in vitro. Prog Clin [I] 4:23

    Google Scholar 

  24. Hedley DW, Nyholm RE, Currie GA (1979) Monocytes and macrophages in malignant melanoma. IV. Effects of C. parvum on monocyte function. Br J Cancer 39:558

    Google Scholar 

  25. Hellstrom I, Warner GA, Hellstrom KE, Sjogren HO (1973) Sequential studies on cell-mediated tumor immunity and blocking serum activity in ten patients with malignant melanoma. Int J Cancer 11:280

    Google Scholar 

  26. Herberman RB (1978) In vitro tests of cellular immunity in man. Invest Cell Pathol 1:227

    Google Scholar 

  27. Herberman RW (1979) Assessment of cellular immune response to cancer of the breast. Ann Clin Lab Sci 9:467

    Google Scholar 

  28. Jones BM, Turnbull AR (1975) Horizontal studies of cell-mediated immune reactions to autologous tumour antigens in patients with operable mammary carcinoma. Br J Cancer 32:33

    Google Scholar 

  29. Karavodin LM, Giuliano AE, Golub SH (1981) T lymphocyte subsets in patients with malignant melanoma. Cancer Immunol Immunother 11:251

    Google Scholar 

  30. Kerman RH, Stefani SS (1978) Effect of BCG immunotherapy on the active-T and total T-RFC in patients with lung cancer. Cancer Immunol Immunother 4:41

    Google Scholar 

  31. Kerman RH, Smith R, Stafani SS et al. (1976) Active T rosette forming cells in the peripheral blood of cancer patients. Cancer Rev 36:3274

    Google Scholar 

  32. Kristensen E, Reimann R (1977) Direct cytotoxicity test applied to patients in Stage I and Ii of malignant skin melanoma. I. Specificity and prognostic value. Cancer Immunol Immunother 2:49

    Google Scholar 

  33. Lamelin J-P, Ellouz R, deThe G, Revillard JP (1977) Lymphocyte subpopulations and mitogenic responses in nasopharyngeal carcinoma, prior to and after radiotherapy. Int J Cancer 20:723

    Google Scholar 

  34. Levin AS, Byers VS, Fudenberg HH, Wybran J, Hackett AJ, Johnston JD, Spitler LE (1975) Immunological parameters before and during immunotherapy with tumor-specific transfer factor. J Clin Invest 55:487–499

    Google Scholar 

  35. Lopez M, O'Connor R, Macfarlane JK, Thomson DMP (1978) The natural history of antitumour immunity in human breast cancer assayed by tube leucocyte adherence inhibition. Br J Cancer 38:660

    Google Scholar 

  36. Martinez-Pineiro JA, Muntanola P, Hidalgo L (1977) Immunological evaluatio of patients with urological cancers. Eur Urol 3:159

    Google Scholar 

  37. McCoy JL, Jerome LF, Cannon GB, Weese JL, Herberman RB (1977) Reactivity of lung cancer patients in leukocyte migration inhibition assays to 3-M potassium chloride extracts of fresh tumor and tissue-cultured cells derived from lung cancer. J Natl Cancer Inst 59:1413

    Google Scholar 

  38. McMahon LJ, Thomson SP, Nugent CA, Denny WF, Miller TP (1980) Persistent lymphocytopenia as a diagnostic feature of bronchogenic carcinoma. Chest 78:583

    Google Scholar 

  39. Neilan BA (1980) Lack of correlation of T and B lymphocytes with stage of colorectal carcinoma. Dis Colon Rectum 23:65

    Google Scholar 

  40. Ninger E, Zemarova D, Kovarik J, Lauerova L (1979) Evaluation of three E-rosette assays in melanoma patients. Cancer Immunol Immunother 6:121

    Google Scholar 

  41. Nishio S, Horii A, Morikawa Y, Kawakita J, Nishijima T, Kishimoto T, Maekawa M (1979) Studies of the nonspecific cellular immune response in patients with urinary bladder carcinoma. Invest Urol 16:336

    Google Scholar 

  42. Oldham D, Weese JL, Herberman RB, Perlin E, et al. (1976) Immunological monitoring and immunotherapy of carcinoma of the lung. Int J Cancer 18:739

    Google Scholar 

  43. Oldham RK, Gail MH, Baker MA, Forbes JT, Heineman W, Hersh E, Carmack Holmes E, Ritts RE, Wright PW (1982) Immunological studies in double blind randomized trial comparing intrapleural BCG against placebo in patients with resected Stage I nonsmall cell lung cancer. Cancer Immunol Immunother 13:154–173

    Google Scholar 

  44. O'Toole C (1977) A 51chromium isotopoe release assay for detecting cytotoxicity to human bladder carcinoma. Int J Cancer 19:324

    Google Scholar 

  45. Payne JE, Meyer JH, Macpherson JG, Nelson DS, Walls RS, Pheils MT (1980) The value of lymphocyte transformation in carcinoma of the colon and rectum. Surg Gynecol Obstet 150:687

    Google Scholar 

  46. Rieche K, Arndt A, Pasternak G (1976) Cellular immunity in mammary cancer patients as measured by the leukocyte migration test (LMT). A follow-up study. Int J Cancer 17:212

    Google Scholar 

  47. Saal JG, Riethmuller LG, Rieber EP, Hadam M, Ehinger H, Schneider W (1977) Regional BCG-therapy of malignant melanoma: In vitro monitoring of spontaneous cytolytic activity of circulating lymphocytes. Cancer Immunol Immunother 3:27

    Google Scholar 

  48. Stefani S, Kerman R, Abbate J (1976) Immune evaluation of lung cancer patients undergoing radiation therapy. Cancer 37:2792

    Google Scholar 

  49. Stewart T, Hollinshead A, Harris JE et al. (1979) Specific active chemoimmunotherapy in lung cancer: A survival study. Recent Results Cancer Res 68:278

    Google Scholar 

  50. Theofilopoulos AN, Dixon FJ (1979) The biology and detection of immune complexes. Adv Immunol 28:89

    Google Scholar 

  51. Thomas JW, Plenderleith IH, Clements DV, Landi S (1975) Observations in immunotherapy of lymphoma and melanoma patients. Clin Exp Immunol 21:82

    Google Scholar 

  52. Thyme GS, Moertel CG, Silvers A (1979) Preoperative lymphocyte counts in peripheral blood in patients with colorectal neoplasms: A correlation with tumor type, Duke's classification, site of primary tumor, and five-year survival rate in 1,000 patients. Dis. Colol Rectum 22:221

    Google Scholar 

  53. Wanebo HJ (1979) Immunologic testing as a guide to cancer management. Surg Clin North Am 59:323

    Google Scholar 

  54. Wanebo HJ, Thaler HT, Hansen JA, Rosen PP, Robbins GF et al. (1978) Immunologic reactivity in patients with primary operable breast cancer. Cancer 41:84

    Google Scholar 

  55. Webster DJT, Richardson G, Baum M, Priestman T, Hughes LE (1979) Effect of treatment on the immunological status of women with advanced breast cancer. Br J Cancer 39:676

    Google Scholar 

  56. Weese JL, Oldham RK, Tormey DC et al. (1977a) Immunologic monitoring in carcinoma of the breast. Surg Gynecol Obstet 145:209

    Google Scholar 

  57. Weese JL, West W, Herberman R, et al. (1977b) Depression of “high affinity” T-cell rosettes indicative of recurrent carcinoma. Surg Forum 28:15

    Google Scholar 

  58. Woosley RE, Mahaley S Jr, Mahaley JL, Miller GM, Brooks WH (1977) Immunobiology of primary intracranial tumors. Neurosurgery 47:871

    Google Scholar 

  59. Wybran J, Fudenberg HH (1973) Thymus-derived rosette-forming cells in various human disease states: Cancer, lymphoma, bacterial and viral infections, and other diseases. J Clin Invest 52:1026

    Google Scholar 

  60. Yoshino J (1981) Studies on postoperative changes of nonspecific cell-mediated immunity in patients with gastric cancer. Nippon Gega Gakkai Zasshi 82:355

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Section of Medical Oncology and Department of Immunology, Rush-Presbyterian-St. Luke's Medical Center, Rush Medical College, 1725 West Harrison Street, 60612, Chicago, IL, USA

    Donald P. Braun & Jules E. Harris

Authors
  1. Donald P. Braun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jules E. Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Braun, D.P., Harris, J.E. Serial immune function testing to predict clinical disease relapse in patients with solid tumors. Cancer Immunol Immunother 15, 165–171 (1983). https://doi.org/10.1007/BF00199159

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00199159

Keywords

Search

Navigation