Summary
Phosphoglucomutase (PGM a1 ) subtypes were determined by isoelectric focusing on samples of 496 unrelated individuals. Ten phenotypes were observed as gene products of four alleles at the PGM1 locus, with the following gene frequencies: PGM a11 =0.631, PGM a21 =0.194, PGM a31 =0.126, and PGM a41 =0.049. A rare phenotype PGM1 (8-a2) was observed.
Zusammenfassung
Die Phosphoglucomutase (PGM a1 )-Untergruppen wurden durch isoelektrische Fokussierung aus Hämolysaten von 496 nicht verwandten Personen bestimmt. Zehn Phänotypen konnten beobachtet werden, die die Genprodukte der vier Allele des PGM1-Genortes darstellen und folgende Genfrequenzen aufwiesen: PGM a11 =0,631, PGM a21 =0,194, PGM a31 =0,126 und PGM a41 =0,049. Ein seltener Phänotyp PGM1 (8-a2) wurde beobachtet.
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References
Bark JE, Harris MJ, Firth M (1976) Typing of the common phosphoglucomutase varients using isoelectric focusing—a new interpretation of the phosphoglucomutase system. J Forens Sci Soc 16:115–120
Bissbort S, Ritter H, Kömpf J (1978) PGM1 subtyping by means of acid starch gel electrophoresis. Hum Genet 45:175–177
Kühnl P, Spielmann W (1978) Investigations of the PGMa 1 polymorphism (phosphoglucomutase—EC 2.7.5.1.) by isoelectric focusing. Hum Genet 43:57–67
Kühnl P, Schmidtmann U, Spielmann W (1977) Evidence for two common alleles at the PGM1 locus (phosphoglucomutase E.C. 2.7.5.1.). Hum Genet 35:210–223
Martin W (1979) Erfahrungen mit der isoelektrischen Fokussierung zur Darstellung von Isoenzympolymorphismen — PGM-System. Ärztl Lab 25:44–46
Radam G (1977) Methoden und Daten zur Anwendung genetischer Enzympolymorphismen in Gerichtsmedizin und Humangenetik. Fortschr Hämatol 4:185–307
Simeoni E, Grüner O (1980) PGMa 1-Subtypisierung — Frequenzen in Schleswig-Holstein — Erfahrungen mit Spurenmaterial. 59. Jahrestagung der Gesellschaft für Rechtsmedizin, 24.–26.9., Heidelberg
Spencer N, Hopkinson DA, Harris H (1964) Phosphoglucomutase polymorphism in man. Nature 204:742–745
Sutton JG, Burgess R (1978) Genetic evidence for four common alleles at the phosphoglucomutase-1 locus (PGM1), detectable by isoelectric focusing. Vox Sang 34:97–103
Welch SG, Swindlehurst CA, McGregor IA, Williams K (1978) Isoelectric focusing of human red cell phosphoglucomutase, the distribution of variant phenotypes in a village population from the Gambia, West Africa. Hum Genet 43:307–313
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Driesel, A.J., Basler, M. & Henke, J. PGM a1 subtyping in Western Germany (Düsseldorf Region). Z Rechtsmed 88, 313–316 (1982). https://doi.org/10.1007/BF00198667
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DOI: https://doi.org/10.1007/BF00198667