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Potentials of capillary gas chromatography in toxicology today

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Summary

The usefulness, the applicability and the limitations of capillary gas chromatography in various types of toxicological analysis were discussed. Technical parameters of capillary gas chromatography, such as type of injector, type of column with regard to material, size, and stationary phase were assessed in view of the requirements of toxicological analysis. The main advantage of capillary gas chromatography, i.e. high separation power, is unfortunately counterbalanced by low loadability and/or speed of analysis. In the present situation capillary gas chromatography is a method of choice in drug screening despite some disadvantages, but in drug-oriented analysis the conventional chromatography on packed columns is probably more useful.

Zusammenfassung

Die Benutzung, Anwendung und Beschränkungen der Kapillargaschromatographie (KGC) in der qualitativen und quantitativen toxikologischen Analytik wurden diskutiert. Technische Parameter der KGC wie Detektortyp, Art der Säule bezüglich Material, Abmessungen und stationäre Phase wurden geschätzt im Rahmen der Anforderungen in der toxikologischen Analytik. Der wichtigste Vorteil der KGC, d.h. eine hohe Trennkraft, ist unglücklicherweise verbunden mit einer niedrigen Beladung bzw. Geschwindigkeit der Analyse. KGC hat gewisse Vorteile in Screening-Verfahren, wobei aber die geringe Beladung in Betracht gezogen werden soll. Für die Arzneimittel-orientierte Analytik ist die konventionelle Chromatographie mit gepackter Säule wahrscheinlich nützlicher.

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Authors and Affiliations

  1. Institute of Forensic Medicine, Academy of Medicine, Grzegorzecka 16, PL-31531, Krakow, Poland

    M. Bogusz

  2. Dept. of Toxicology, State University, Antonius Deusinglaan 2, NL-9713 AW, Groningen, The Netherlands

    J. P. Franke & R. A. de Zeeuw

Authors
  1. M. Bogusz
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  2. J. P. Franke
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  3. R. A. de Zeeuw
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Bogusz, M., Franke, J.P. & de Zeeuw, R.A. Potentials of capillary gas chromatography in toxicology today. Z Rechtsmed 93, 237–250 (1984). https://doi.org/10.1007/BF00198649

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  • DOI: https://doi.org/10.1007/BF00198649

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