Summary
Fifty six patients, with histologically confirmed cancer, who received highly emetogenic chemotherapy, were entered on a randomized double blind, low versus high dose, study of granisetron, a 5HT3 receptor antagonist. A single dose of intravenous granisetron protected the majority of patients from nausea and vomiting, 160 μg/kg was more effective than 40 μg/kg with no more side effects. Additional doses of granisetron conferred added benefit to patients who experienced breakthrough symptoms. Granisetron at a dose range of 40–240 μg/kg over a 24 hour period was well tolerated with the only side effect being mild headache.
Similar content being viewed by others
References
Miner WD, Sanger GD: Inhibition of cisplatin-induced vomiting by selective 5-hydroxy-tryptamine M-receptor antagonism. Br J Pharmacol 88:497–499, 1986
Falkson G, Van Zyl AJ: A Phase I study of a new 5HT3-receptor antagonist, BRL43694A, an agent for the prevention of chemotherapy-induced nausea and vomiting. Cancer Chemother Pharmacol 193–196, 1989
Fozard JR, Mobarok Ali ATM: Blockade of neuronal tryptamine receptors by metoclopramide. Eur J Pharmacol 49:109–112, 1978
Hesketh PJ, Murphy WK, Lester EP, Gandara DR, Khojasteh A, Tapazoglou E, Sartiano GP, White DR, Werner K, Chubb JM: GR38032F (GR-C507/75): a novel compound effective in the prevention of acute cisplatin-induced emesis. J Clin Oncol 7:700–705, 1989
Green JA, Watkin SW, Hammond P, Griggs J, Challoner T: The efficacy and safety of GR38032F in the prophylaxis of ifosfamide-induced nausea and vomiting. Cancer Chemother Pharmacol 24:137–139, 1989
Carmichael J, Cantwell BMJ, Edwards CM, Zussman BD, Thompson S, Rapeport WG, Harris AL: A pharmacokinetic study of granisetron (BRL 43694A), a selective 5-HT3 receptor antagonist: correlation with antiemetic response. Cancer Chemother Pharmacol 24:45–49, 1989
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Falkson, H.C., Falkson, C.I. & Falkson, G. High versus low dose granisetron, a selective 5HT3 antagonist, for the prevention of chemotherapy-induced nausea and vomiting. Invest New Drugs 8, 407–409 (1990). https://doi.org/10.1007/BF00198602
Issue Date:
DOI: https://doi.org/10.1007/BF00198602