Abstract
Neuroblastoma is a potentially curable child-hood malignancy with survival rates of 20% reported even in advanced disease. Technetium-labelled methylene diphosphonate (Tc99m-MDP) scanning is well established as a method of assessing bone disease. We report four patients, with advanced neuroblastoma in complete or partial remission, in whom new abnormalities on bone scintigraphy were due to benign lesions. Correct management depends on the precise diagnosis of such lesions.
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Brodeur GM, Seeger RC, Barrett A, Berthold F, Castleberry RP, D'Angio G, DeBernardi B, Evans AE, Favrot M, Freeman AI, Haase G, Hartmann O, Hayes FA, Helson L, Kemshead J, Lampert F, Ninane J, Ohkawa H, Philip T, Pinkerton CR, Pritchard J, Sawada T, Siegel S, Smith EI, Tsuchida Y, Voute PA (1988) International criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma. J Clin Oncol 6:1874
Cawley KA, Dvorak AD, Wilmot MD (1983) Normal anatomic variant: scintigraphy of the ischiopubic synchondrosis. J Nucl Med 24:14
Edeling C-J, Frederiksen PV, Kamper J, Jeppesen P (1987) Diagnosis and treatment of neuroblastoma using metaiodobenzyl-guanidine. Clin Nucl Med 12:632
Geatti O, Shapiro B, Sisson JC, Hutchinson RJ, Mallette S, Eyre P, Beirewaltes WH (1985) Iodine-131 metaiodobenzylguanidine scintigraphy for location of neuroblastoma: Preliminary experience in ten cases. J Nucl Med 26:736
Gilday GL, Ash JM, Reilly BJ (1977) Radionuclide skeletal survey for pediatric neoplasms. Radiology 123:399
Gordon I, Peters AM, Gutman B (1988) Accuracy of metaiodobenzylguanidine (1123MIBG) in neuroblastoma. Nucl Med Commn 9:174 (abstract)
Hadley GP, Rabe E (1986) Scanning with Iodine-131 in children with solid tumors. An initial appraisal. J Nucl Med 27:620
Hoefnagel CA, Voute PA, deKraker J, Marcuse HR (1987) Radionuclide diagnosis and therapy of neural crest tumors using Iodine-131 metaiodobenzylguanidine. J Nucl Med 28:308
Howman-Giles RB, Gilday DL, Ash JM (1979) Radionuclide skeletal survey in neuroblastoma. Radiology 131:497
Kaufman RA, Thrall JH, Keyes JW, Brown ML, Zakem JF (1978) False negative bone scans in neuroblastoma metastatic to the ends of long bones. AJR 130:131
Kiess W, Leisner B, Haas R (1985) Coincidence of infectious osteomyelitis and disseminated neuroblastoma: A diagnostic dilemma solved by scintigraphic imaging. J Cancer Res Clin Oncol 110:85
Pistenma DA, McDougall IR, Kriss JP (1975) Screening for bone metastases. JAMA 231:46
Podrasky AE, Stark DD, Hattner RS, Gooding CA, Moss AA (1982) Radionuclide bone scanning in neuroblastoma: Skeletal metastases and primary tumor localisation of 99mTc-MDP. AJR 141:469
Pritchard J, Gordon I, Lashford L, Dicks-Mireaux C (1988) Specificity of iodobenzylguanidine scanning in neuroblastoma. Lancet 479
Pritchard J, Kiely E, Rogers DW, Spitz L, Shafford EA, Brereton R, Muller C, Wright VM (1987) Long-term survival after advanced neuroblastoma. N Engl J Med 317:1026
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Hall-Craggs, M.A., Shaw, D., Pritchard, J. et al. Metastatic neuroblastoma: new abnormalities on bone scintigraphy may not indicate tumour recurrence. Skeletal Radiol. 19, 33–36 (1990). https://doi.org/10.1007/BF00197926
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DOI: https://doi.org/10.1007/BF00197926