Summary
A family with 11 normal boys has been typed with DNA probes spanning the whole of the X-chromosome to observe directly the recombination events in 11 meioses from one female. This has (a) identified apparent recombination hot-spots on the X-chromosome; (b) shown the positions and numbers of cross-overs that have occurred in the p and q arms; (c) not shown any cross-overs in the centromeric region and (d) enabled the calculation of the genetic length of the X-chromosome.
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References
Arveiler B, Oberlé I, Mandel J-L (1987) Genetic mapping of nine DNA markers in the q11–q22 region of the human X-chromosome. Genomics 1:60–66
Baumach LL, Chamberlain JS, Ward PA, Farwell NJ, Caskey CT (1989) Molecular and clinical correlations of deletions leading to Duchenne and Becker muscular dystrophies. Neurology 39:465–474
Botstein D, White RL, Skolnick M, Davis RW (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet 32:314–331
Donis-Keller H, et al (1987) A genetic linkage map of the human genome. Cell 51:319–337
Drayna D, Davies K, Hartley D, Mandel J-L, Camerino G, Williamson R, White R (1984) Genetic mapping of the human X-chromosome by using restriction fragment length polymorphisms. Proc Natl Acad Sci USA 81:2836–2839
Feinberg AP, Vogelstein B (1983) A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Addendum. Anal Biochem 137:266–267
Hamerton JL, Jacobs PA, Klinger HP (1972) Paris conference 1971:Standardization in human cytogenetics. Birth Defects, Original Article Series VIII, 7
Hulten MA (1974) Chiasma distribution at diakinesis in the normal human male. Hereditas 76:55–78
Human Gene Mapping 10 (1989) 10th International Workshop on Human Gene Mapping. Cytogenet Cell Genet 51:1–1147
Keats B, Ott J, Conneally M (1989) Report of the committee on linkage and gene order. (10th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 51:459–502
Kosambi DD (1944) The estimation of map distances from recombination values. Ann Eugen 12:172–175
Lalouel JM (1977) Linkage mapping from pair-wise recombination data. Heredity 38:61–77
Laurie DA, Hulten MA (1985a) Further studies on bivalent chiasma frequency in human males with normal karyotypes. Ann Hum Genet 49:181–201
Laurie DA, Hulten MA (1985b) Further studies on chiasma distribution and interference in the human male. Ann Hum Genet 49:203–214
Mandel J-L, Willard HF, Nussbaum RL, Romeo G, Puck JM, Davies KE (1989) Report of the committee on the genetic constitution of the X-chromosome. (10th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 51:384–437
Morton NE, Rao DL, Lindstein J, Hulten M, Yee S (1977) Chiasma map of man. Hum Hered 27:38–55
Rao DC, Morton NE, Lindsten J, Hutten M, Yee S (1977) A mapping function for man. Hum Hered 27:99–104
Wapenaar MC, et al (1988) A deletion hotspot in the Duchenne muscular dystrophy gene. Genomics 2:101–108
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Del Mastro, R.G., Farndon, P.A. & Kilpatrick, M.W. A recombination map of the human X-chromosome. Hum Genet 86, 228–230 (1990). https://doi.org/10.1007/BF00197710
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DOI: https://doi.org/10.1007/BF00197710