Abstract
Radiographs were reviewed in a group of nine patients with classical seropositive rheumatoid arthritis who on tissue typing were found to express the class I HLA-B27 allele. Radiographs were analyzed with regard to whether or not they demonstrated radiographic features of (1) classical rheumatoid arthritis, (2) seronegative arthritis, or (3) mixed features of rheumatoid and seronegative arthritis. Five patients (55%) displayed radiographic features consistent with a diagnosis of rheumatoid arthritis, two patients (22%) showed radiographic features of seronegative disorder (periostitis and sacroiliitis), and two patients (22%) showed a mixed picture with evidence of both rheumatoid arthritis and a seronegative disorder. Thus, the HLA-B27 allele contributed to the radiographic features in 44% of patients with rheumatoid arthritis and associated HLA-B27. Thus, the wide range of findings in our population indicates that the radiographic attributes are not specific enough to constitute a unique subpopulation of patients with rheumatoid arthritits.
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Alarcon-Segovia D, Martinez-Cordero E (1985) Ankylosing spondylitis and rheumatoid arthritis in a patient with Paget's disease: differential effects of indomethacin, d-penicillamine. or gold sodium thiomalate in the respective arthritides. Arch Int Med 145:1915
Alexander E, Bias W, Arnett F (1981) The coexistence of rheumatoid arthritis with Reiter's syndrome and/or ankylosing spondylitis. J Rheumatol 8:398
Dahlqvist SR (1988) HLA B27 and rheumatoid arthritis in Northern Sweden. Arctic Med Res 47:452
Dahlqvist SR, Nordmark LG, Bjelle A (1984) HLA-B27 and involvement of sacroiliac joints in rheumatoid arthritis. J Rheumatol 11:27
El-Khoury GY, Larson R, Kathol M et al. (1988) Seronegative and seropositive rheumatoid arthritis: radiographic differences. Radiology 168:517
Fallahi S, Halla J, Hardin J (1982) The influence of B27 antigen on the clinical and radiographic picture of definite or classical rheumatoid arthritis. J Rheumatol 9:13
Fallet G, Barnes C, Berry H et al. (1987) Coexisting rheumatoid arthritis and ankylosing spondylitis. J Rheumatol 14:1135
Helfgott S, Lazarides G, Sandberg-Cook J (1988) Co-occurrence of rheumatoid arthritis and ankylosing spondylitis (letter to the Editor). J Rheumatol 15:1451
Jurik AG, de Carvalho A, Graudal H (1987) Radiographic visualization of seropositive rheumatoid arthritis in carriers of HLA-B27. Fortschr Röntgenstr Nuklearmed Ergänzungsband 147:14
Sattar MA, Al-Sughyer A, Siboo R (1988) Coexistence of rheumatoid arthritis, ankylosing spondylitis and dermatomyositis in a patient with diabetes mellitus and the associated linked HLA antigens. Br J Rheumatol 27:146
Tarp U, Graudal HK (1989) Seropositive rheumatoid arthritis in monozygotic twin sisters carrying HLA-DR4 or DR4 associated with B27. J Rheumatol 16:1530
Young A, Corbett M, Winfield J et al. (1988) A prognostic index for erosive changes in the hands, feet and cervical spines in early rheumatoid arthritis. Br J Rheumatol 27:94
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Rundback, J.H., Rosenberg, Z.S. & Solomon, G. The radiographic features of rheumatoid arthritis in HLA-B27-positive patients. Skeletal Radiol. 22, 263–267 (1993). https://doi.org/10.1007/BF00197671
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DOI: https://doi.org/10.1007/BF00197671