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Human tumor necrosis factor increases the resistance against Listeria infection in mice

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Abstract

The resistance in mice against Listeria infection was augmented by treatment with recombinant human tumor necrosis factor (TNF). To elucidate this phenomenon, we examined the effect of TNF on macrophage activation. TNF-treated macrophages had listericidal activity in vitro and superoxide anion production. In addition, macrophage migration was inhibited in the presence of TNF. Therefore, activation of macrophages by TNF was similar to activation by macrophage-activating factor or macrophage-migration-inhibitory factor.

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Authors and Affiliations

  1. Department of Internal Medicine, Tomakomai City Hospital, 1-2-21, Honkou-chyo, 053, Tomakomai, Japan

    Kazuyuki Kato

  2. Department of Bacteriology, Hokkaido University, Sapporo, Hokkaido, Japan

    Akio Nakane & Tomonori Minagawa

  3. Institute for Animal Experiment, School of Medicine Hokkaido University, Sapporo, Hokkaido, Japan

    Noriyuki Kasai

  4. Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido, Japan

    Ken-ichi Yamamoto

  5. Department of Biochemistry, the National Defense Medical College, Tokorozawa, Saitama, Japan

    Noboru Sato

  6. Suntory Institute for Biomedical Research, Mishima, Osaka, Japan

    Nobuo Tsuruoka

Authors
  1. Kazuyuki Kato
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  2. Akio Nakane
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  3. Tomonori Minagawa
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  4. Noriyuki Kasai
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  5. Ken-ichi Yamamoto
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  6. Noboru Sato
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  7. Nobuo Tsuruoka
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Kato, K., Nakane, A., Minagawa, T. et al. Human tumor necrosis factor increases the resistance against Listeria infection in mice. Med Microbiol Immunol 178, 337–346 (1989). https://doi.org/10.1007/BF00197452

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  • DOI: https://doi.org/10.1007/BF00197452

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