Skip to main content
SpringerLink
Log in

Immunological responses of weanling cotton rats (Sigmodon hispidus) to acute benzene and cyclophosphamide exposure

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Abraham NG, Lutton JO, Freedman ML, Levere RD (1986) Benzene modulation of liver cell function and heme cytochrome P450 metabolism. Am J Med Sci 292:81–86

    Google Scholar 

  • Aoyama K (1986) Effects of benzene inhalation on lymphocyte subpopulations and immune response in mice. Toxicol Appl Pharmacol 85:92–101

    Google Scholar 

  • Bach JF, Strom TB (1985) The mode of action of immunosuppressive agents. Res Mono Immunol vol 9. Elsevier Scicnce Publishers. New York

    Google Scholar 

  • Biozzi G, Mouton D, Stiffel C, Bouthillier Y (1984) A major role of the macrophage in quantitative genetic regulation of immunoresponsiveness and antiinfectious immunity. Adv Immunol 36:189–234

    Google Scholar 

  • Dean JH, Padarathsingh ML, Jerrells TR, Keys L, Northing JW (1979) Assessment of immunobiological effects induced by chemicals, drugs or food additives. II. Studies with cyclophosphamide. Drug Chem Toxicol 2:133–153

    Google Scholar 

  • Faith RE, Luster MI, Vos JG (1980) Effects on immunocompetence by chemicals of environmental concern. Ann Rev Biochem Toxicol 2:173–211

    Google Scholar 

  • Gerarde HW, Ahlstrom DB (1966) Toxicologic studies on hydrocarbons. XI. Influence of dose on the metabolism of mono-n-alkyl derivatives of benzene. Toxicol Appl Pharmacol 9:185–190

    Google Scholar 

  • Gershwin ME, Beach RS, Hurley LS (1985) Nutrition and immunity. Academic Press, Inc., Orlando, FL.

    Google Scholar 

  • Irons RD, Heck HD'A, Moore BJ, Muirhead KA (1979) Effects of short-term benzene administration on bone marrow cell cycle kinetics in the rat. Toxicol Appl Pharmacol 51:399–409

    Google Scholar 

  • Johnson RA, Prince GA, Suffin SC, Horswood RL, Chanock RM (1982) Respiratory syncytial virus infection in cyclophosphamide-treated cotton rats. Infect Immun 37: 369–373

    Google Scholar 

  • McMurry ST, Lochmiller RL, Vestey MR, Qualls CW Jr., Elangbam CS (1991) Acute effects of benzene and cyclophosphamide exposure on cellular and humoral immunity of cotton rats, Sigmodon hispidus. Bull Environ Contam Toxicol 46:937–945

    Google Scholar 

  • Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immuno Meth 65:55–63

    Google Scholar 

  • Murgita RA, Wigzell H (1981) Regulation of immune functions in the fetus and newborn. pp 54–133 in Progress in Allergy. Waksman (ed). Vol. 29. S. Karger, New York

    Google Scholar 

  • Parmentier R, Dustin P Jr., (1948) Early effects of hydroquinone on mitosis. Nature 161:527–528

    Google Scholar 

  • Pfeifer RW, Irons RD (1981) Inhibition of lectin-stimulated lymphocyte agglutination and mitogenesis by hydroquinone: reactivity with intracellular sulfhydryl groups. Exper Molec Path 35:189–198

    Google Scholar 

  • Rosenthal GJ, Snyder CA (1987) Inhaled benzene reduces aspects of cell-mediated tumor surveillance in mice. Toxicol Appl Pharmacol 88:35–43

    Google Scholar 

  • Rowley MH, Christian JJ, Basu DK, Pawlikoski MA, Paigon B (1983) Use of small mammals (voles) to assess a hazardous waste site at Love Canal, Niagara Falls, New York. Arch Environ Contam Toxicol 12:383–397

    Google Scholar 

  • SAS Institute Inc (1985) SAS user's guide: statistics, version 5 edition. Cary, NC: SAS institute inc 956p

    Google Scholar 

  • Shand FL (1979) Review/commentary The immunopharmacology of cyclophosphamide. Int J Immunopharmac 1:165–171

    Google Scholar 

  • Sipes G, Gandolfi AJ (1986) Biotransformation of toxicants. pp 64–98 in Casarett and Doull's Toxicology: The Basic Science of Poisons. Doull J, Klaassen CD, Amdur MO (eds). MacMillan Publishing Co., Inc., New York

    Google Scholar 

  • Snyder CA (1987) Benzene. pp 3–37 in Ethel Browning's toxicity and metabolism of industrial solvents. Snyder R (ed). Elsevier Science Publishers, New York

    Google Scholar 

  • Snyder R, Kocsis JJ (1975) Current concepts of chronic benzene toxicity. CRC Critical Rev Toxicol 3:265–288

    Google Scholar 

  • Travis CC, Quillen JL, Arms AD (1990) Pharmacokinetics of benzene. Toxicol Appl Pharmacol 102:400–420

    Google Scholar 

  • Vos G (1977) Immune suppression as related to toxicology. CRC Critical Rev Toxicol 5:67–101

    Google Scholar 

  • Wierda D, Irons RD, Greenlee WF (1981) Immunotoxicity in C57BL/6 mice exposed to benzene and Aroclor 1254. Toxicol Appl Pharmacol 60:410–417

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Zoology, Oklahoma State University, 74078, Stillwater, Oklahoma, USA

    Scott T. McMurry, Robert L. Lochmiller & Michelle R. Vestey

  2. Department of Veterinary Pathology, Oklahoma State University, 74078, Stillwater, Oklahoma, USA

    Charles W. Qualls Jr.

Authors
  1. Scott T. McMurry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert L. Lochmiller
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michelle R. Vestey
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Charles W. Qualls Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

McMurry, S.T., Lochmiller, R.L., Vestey, M.R. et al. Immunological responses of weanling cotton rats (Sigmodon hispidus) to acute benzene and cyclophosphamide exposure. Bull. Environ. Contam. Toxicol. 52, 155–162 (1994). https://doi.org/10.1007/BF00197372

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00197372

Keywords

Search

Navigation