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The role of prostaglandins in altered leukocyte function in multiple sclerosis

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References

  1. Antel JP, Arnason BGW, Medof ME (1979) Suppressor cell function in multiple sclerosis: Correlation with clinical disease activity. Ann Neurol 5: 338

    Google Scholar 

  2. Antel JP, Oger J, Jackevicius S, Kuo H-H, Arnason BGW (1982) Modulation of T-lymphocyte differentiation antigens: Potential release for multiple sclerosis. Proc Natl Acad Sci USA 79: 3330

    Google Scholar 

  3. Barna BP, Goren H, Jacobs BS, Conomy I, Doedhar SD (1981) Analysis of leukocyte adherence to measles infected cells in multiple sclerosis. Ann Neurol 9: 28

    Google Scholar 

  4. Bell RL, Kennerly DA, Stanford N, Majerus P (1979) Diglyceride lipase: A pathway for arachidonic acid from human platelets. Proc Natl Acad Sci USA 76: 3238

    Google Scholar 

  5. Blackwell GJ, Flower RJ, Nijkamp FP, Vane RJ (1978) Phospholipase A2 activity of guinea pig isolated perfused lungs: Stimulation and inhibition by anti-inflammatory steroids. Br J Pharmacol 62: 79

    Google Scholar 

  6. Blackwell GJ, Carnuccio R, DiRosa M, Flower, RJ, Parente L, Persico P (1980) Macrocortin: A polypeptide causing the antiphospholipase effect of glucocorticoids. Nature 287: 147

    Google Scholar 

  7. Bonney RJ, Naruns P, Davies P, Humes JL (1979) Antigens — antibody complexes stimulate the synthesis and release of prostaglandins by mouse peritoneal macrophages. Prostaglandins 18: 605

    Google Scholar 

  8. Bonney RJ, Wightman PD, Dahlgren ME, Davies P, Kuehl FA Jr, Humes JL (1980) Release of inflammatory mediators by macrophages in response to phorbol myristate acetate: Effect of RNA and protein synthesis inhibitors. Biochim Biophys Acta 633: 410

    Google Scholar 

  9. Booss J, Esiri MM, Tourtellotte WW, Mason D (1983) Immunohistological analysis of T lymphocyte subset in the central nervous system in chronic progressive multiple sclerosis. J Neurol Sci 62: 219

    Google Scholar 

  10. Bolton C, Turner AM, Turk JL (1984) Prostaglandin levels in cerebrospinal fluid from multiple sclerosis patients in remission and relapse. J Neuroimmunol 6: 151

    Google Scholar 

  11. Carofoli E, Crovetti F (1973) Interactions between PGE1 and Ca2+ at the level of the mitochondrial membrane. Arch Biochem Biophys 154: 40

    Google Scholar 

  12. Carsten ME, Miller JD (1977) Effects of prostaglandin and oxytocin on calcium release from a uterine microsomal fraction: Hypothesis for ionophoretic actions of prostaglandins. J Biol Chem 252: 1576

    Google Scholar 

  13. Cashman N, Martin C, Eisenbaum JF, Degos JD, Bach MA (1982) Monoclonal antibody — defined immunoregulatory cells in multiple sclerosis cerebrospinal fluid. J Clin Invest 70: 387

    Google Scholar 

  14. Chang JA, Lewis GP, Piper PJ (1977) Inhibition by glucocorticoids of prostaglandin release from adipose tissue in vitro. Br J Pharmacol 59: 425

    Google Scholar 

  15. Cunningham FM, Carter HR, Smith MJ, Ford-Hutchinsan AW, Bray MA (1981) Aggregation of polymorphonuclear leukocytes by leukotriene B: Effects of cyclooxygenase products and metabolic inhibitors. Agents Actions 11: 583

    Google Scholar 

  16. Diaz-Perez JL, Goldyne ME, Winkelmann RK (1976) Prostaglandins and chemotaxis: Enhancement of polymorphonuclear leukocyte chemotaxis by prostaglandin F2. J Invest Determatol 66: 149

    Google Scholar 

  17. Dore-Duffy P, Zurier RB (1979) E-rosette formation in normals and patients with multiple sclerosis. Effect of prostaglandin and aspirin. Clin Immunol Immunopathol 13: 261

    Google Scholar 

  18. Dore-Duffy P, Zurier RB (1979) Lymphocyte adherence in multiple sclerosis. Effect of aspirin. J Clin Invest 63: 154

    Google Scholar 

  19. Dore-Duffy P, Zurier RB (1981) Lymphocyte adherence in multiple sclerosis. Role of monocytes and increased sensitivity of MS lymphocytes to prostaglandin E. Clin Immunol Immunopathol 19: 303

    Google Scholar 

  20. Dore-Duffy P, Zurier RB (1983) Lymphocyte adherence in multiple sclerosis: Lack of virus specificity. Cell Immunol 77: 215

    Google Scholar 

  21. Dore-Duffy P, Zurier RB, Donaldson JO, Nystrom SS, Viola MV, Rothman B, Thompson HG (1979) Lymphocyte adherence in multiple sclerosis. Neurology 29: 232

    Google Scholar 

  22. Dore-Duffy P, Geortz V, Rothman RB (1980) Lymphocyte adherence to myelinated tissue in multiple sclerosis. J Clin Invest 66: 843

    Google Scholar 

  23. Dore-Duffy P, Koff TS, Zurier RB (1981) Adherence of human peripheral blood leukocytes to virus infected cells: Role of the cytoskeleton and prostaglandin E. Prostaglandins Med 6: 299

    Google Scholar 

  24. Dore-Duffy P, Siok C, Donaldson JO (1982) Prostaglandin E synthesis in patients with multiple sclerosis: Correlation with disease activity. Neurology (NY) 32: 164

    Google Scholar 

  25. Dore-Duffy P, Kuo H-H, Dowling MM (1983) Role of prostaglandin E in modulation of T-cell differentiation antigens: Implication for multiple sclerosis. Neurology (NY) 33: 142

    Google Scholar 

  26. Dore-Duffy P, Catalanotto F, Donaldson JO, Ostrom KM, Testa MA (1983) Zinc in multiple sclerosis. Ann Neurol 14: 450

    Google Scholar 

  27. Dunham EW, Haddox MK, Goldberg ND (1974) Alteration of vein cyclic 3′, 5′ nucleotide concentrations during changes in contractility. Proc Natl Acad Sci USA 71: 815

    Google Scholar 

  28. Dworkin RH, Bates D, Millar JHD, Daty DW (1984) Linoleic acid and multiple sclerosis: A reanalysis of three double blind trials. Neurology (NY) 34: 1441

    Google Scholar 

  29. Egg D, Herald M, Rumpl E, Gunther R (1980) Prostaglandin F2a levels in human cerebrospinal fluid in normal and pathological conditions. J Neurol 222: 239

    Google Scholar 

  30. Evans GW, Grace CI, Votava HJ (1975) A proposed mechanism of zinc absorption in the rat. Am J Physiol 228: 501

    Google Scholar 

  31. Gemsa E, Seitz M, Kramer W, Till G, Resch K (1978) The effects of phagacytosis, dextran sulfate, and cell damage on PGE, sensitivity and PGE, production of macrophages. J Immunol 120: 1187

    Google Scholar 

  32. Gemsa D, Kramer W, Brenner M, Till G, Resch K (1980) Induction of PGE release from macrophages by colchicine. J Immunol 124: 376

    Google Scholar 

  33. Gemsa D, Leser H-G, Seitz M, Deimann W, Barlin E (1982) Membrane pertribution and stimulation of arachidonic acid metabolism. Mol Immunol 19: 1287

    Google Scholar 

  34. Goff AK, Zamecnik J, Ali M, Armstrong DT (1978) Prostacyclin stimulation of granulosa cell cyclic AMP production. Prostaglandin 15: 875

    Google Scholar 

  35. Goodman MG, Weigle WO (1984) Regulation of B-lymphocyte proliferative responses by arachidonate metabolities: Effects on membrane-directed versus intracellular activators. J Allergy Clin Immunol (Suppl) 74: 418

    Google Scholar 

  36. Goodwin JS, Messner RP (1978) Prostaglandin E inhibition of mitogen stimulation in patients with multiple sclerosis. Prostaglandins 15: 281

    Google Scholar 

  37. Goodwin JS, Kaszubowski PA, Williams RC Jr (1979) Cyclic adenosine monophosphate response to PGE2 on subpopulations of human lymphocytes. J Exp Med 150: 1260

    Google Scholar 

  38. Gualde N, Goodwin JS (1982) Effects of PGE and preincubation on lectin-stimulated proliferation of human T cell subsets. Cell Immunol 70: 373

    Google Scholar 

  39. Ham EA, Soderman DD, Zanetti ME, Dougherty HW, McCauley E, Kuehl FA Jr (1983) Inhibition by prostaglandin of leukotriene B4 release from activated neutrophilis. Proc Natl Acad Sci USA 80: 4349

    Google Scholar 

  40. Hauser SJ, Ault KA, Leuin MJ, Garouay MR, Weiner HL (1981) Natural killer cell activity in multiple sclerosis. J Immunol 127: 1114

    Google Scholar 

  41. Herscowitz HB, Stylos WA (1975) Prostaglandin-induced enhancement of the in vitro anamnestic response. Prostaglandins 10: 88

    Google Scholar 

  42. Honda M, Steinberg AD (1984) Effects of prostaglandin E2 on responses of T-cell subsets to mitogen and autologous non-t-cell stimulation. Clin Immunol Immunopathol 33: 111

    Google Scholar 

  43. Huddlestone JR, Oldstone MBA (1979) T suppressor (Tg) lymphocytes fluctuate in parallel with changes in the clinical course of patients with multiple sclerosis. J Immunol 123: 1615

    Google Scholar 

  44. Hughes D, Keith AB, Mertin J, Caspary EA (1981) Linoleic acid therapy in severe allergic encephalomyelitis in the guinea pig: Suppression by continuous treatment. Clin Exp Immunol 41: 523

    Google Scholar 

  45. Humes JL, Bonney RJ, Pelus L, Dahlgreen ME, Sadowski SJ, Kuehl FA, Davies P (1977) Macrophages synthesize and release prostaglandins in response to inflammatory stimuli. Nature 269: 149

    Google Scholar 

  46. Humes JL, Sadowski S, Galavage M, Goldenberg MM, Subers E, Kuehl FA Jr, Bonney RJ (1983) Pharmacological effects of non-steroidal anti-inflammatory agents or prostaglandin and leukotriene synthesis by mouse peritoneal macrophages. Biochem Pharmacol 32: 2319

    Google Scholar 

  47. Janssen PAJ (1975) Suprojen (R25–061); A new potent inhibitor of prostaglandin biosynthesis. Arzneimittelforsch 25: 1495

    Google Scholar 

  48. Kadowitz PJ, Joiner PD, Hyman AL, George WJ (1975) Influence of prostaglandins E1 and F2 on pulmonary vascular resistance isolated lobar vessels and cyclic nucleotide levels. J Pharmacol Exp Ther 192: 677

    Google Scholar 

  49. Kaley G, Weiner R (1971) Prostaglandin E1: A potential mediator of the inflammatory response. Ann NY Acad Sci 180: 338

    Google Scholar 

  50. Kennedy MS, Insel PA (1979) Inhibitors of microtubule assembly enhance beta-adrenergic and prostaglandin E, — stimulated cyclic AMP accumulation in S49 lymphoma cells. Mol Pharmacol 16: 215

    Google Scholar 

  51. Kirby J, Morley J, Ponsford JR, McDonald WI (1976) Defective PGE reactivity in leucocytes of multiple sclerosis patients. Prostaglandins 11: 621

    Google Scholar 

  52. Kirkland SJ, Baum H (1972) PGE, may act as a calcium ionophore. Nature 236: 926

    Google Scholar 

  53. Klein DC, Raisz LG (1970) Prostaglandin stimulation of bone restoration in tissue culture. Endocrinology 84: 1436

    Google Scholar 

  54. Kosman DJ, Henkin RI (1979) Plasma and serum zinc concentrations. Lancet 1: 140

    Google Scholar 

  55. Kuehl FA Jr, Circillo VJ, Ham EA, Humes JL (1973) The regulatory role of the prostaglandins on the cyclic 3′ 5′ AMP system. Adv Biosci 9: 155

    Google Scholar 

  56. Kunze H, Vogat W (1971) Significance of phospholipase A2 for prostaglandin formation. Ann NY Acad Sci 180: 122

    Google Scholar 

  57. Kurland JL, Bockman RJ (1978) Prostaglandin E production by human blood monocytes and mouse peritoneal macrophages. J Exp Med 147: 952

    Google Scholar 

  58. Levy NL, Auerbach PS, Hayes EC (1976) A blood test for multiple sclerosis based on the adherence of lymphocytes to measles infected cells. N Engl J Med 294: 1423

    Google Scholar 

  59. Lewis RA, Austen FA (1981) Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds. Nature 293: 103

    Google Scholar 

  60. Lisak RP, Mercado R, Zweiman B (1979) Cold reactive antilymphocyte antibodies in neurological disease. J Neurol Neurosurg Psychiatry 42: 1054

    Google Scholar 

  61. Loose LD, DiLuzio NR (1983) Effect of prostaglandin E1 on cellular and humoral immune responses. J Reticuloendothel Soc 13: 70

    Google Scholar 

  62. Meade CJ, Merton J, Sheena J, Hunt R (1978) Reduction by linoleic acid of the severity of experimental allergic encephalomyelitis in the guinea pig. J Neurol Sci 35: 291

    Google Scholar 

  63. Melmon KL, Bourne HR, Weinstein Y, Shearer GM, Kram J, Bauminger S (1974) Hemolytic plaque formation by leucocytes in vitro control by vasoactive hormones J Clin Invest 53: 13

    Google Scholar 

  64. Merrill JE, Jondal M, Seeley J, Ullberg M, Siden A (1982) Decreased NK killing inpatients with multiple sclerosis — An analysis on the level of the single effector cell from peripheral blood and cerebrospinal fluid in relation to the activity of the disease. Clin Exp Immunol 47: 419

    Google Scholar 

  65. Merill JE, Scott A, Myers L, Ellison G (1982) Cytotoxic activity of peripheral blood and cerebrospinal fluid lymphocytes from patients with multiple sclerosis and other neurological diseases — Analysis at the single cell level using morphological and surface marker phenotype criteria. J Neuroimmunol 3: 123

    Google Scholar 

  66. Merrill JE, Gerner RH, Myers LW, Ellison GW (1983) Regulation of natural killer cell cytotoxicity by prostaglandin E in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. I. Association between amount of prostaglandin produced, natural killer, and endogenous interferon. J Neuroimmunol 4: 223

    Google Scholar 

  67. Merrill JE, Myers LW, Ellison GW (1983) Regulation of natural killer cell cytoxicity by prostaglandin E in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. II. Effect of exogenous PGE on spontaneous and interferon induced NK. J Neuroimmunol 4: 238

    Google Scholar 

  68. Mertin J, Stockpoole A (1973) Suppression by essential fatty acids of experimental allergic encephalomyelitis is abolished by indomethacin. Prostaglandins Med 1: 283

    Google Scholar 

  69. Miyamoto T, Yamamoto S, Hayaishi O (1974) Prostaglandin synthetase system — Resolution into oxygenase and isomerase components. Proc Natl Acad Sci USA 71: 3645

    Google Scholar 

  70. Morley J, Bray MA, Jones RW, Nugteren PH, Van Dorp CA (1979) Prostaglandin and thromboxane production by human and guinea pig macrophages and leukocytes. Prostaglandins 17: 1729

    Google Scholar 

  71. Neighbor A, Bloom BR (1979) Absence of virus-induced lymphocyte suppression and interferon production in multiple sclerosis. Proc Natl Acad Sci USA 76: 476

    Google Scholar 

  72. Nyland H, Mork S, Matre R (1983) T cell subsets and lipid macrophages in multiple sclerosis lesions in situ characterization using monoclonal antibodies. Acta Neurol Scand 67: 188

    Google Scholar 

  73. Offner H, Danneskiold-Samsøe B, Dore-Duffy P (1982) Effect of prostaglandins and aspirin on active E-rosette formation in patients with multiple sclerosis. Clin Immunol Immunopathol 22: 159

    Google Scholar 

  74. Oger JL, Arnason BGW, Wray SH, Listler JP (1975) A study of B and T cells in multiple sclerosis. Neurology (NY) 25: 444

    Google Scholar 

  75. Passwell JH, Dayer J-M, Merler E (1979) Increased prostaglandin synthesis by human monocytes after membrane receptor activation. J Immunol 123: 115

    Google Scholar 

  76. Piper O, Vane JR (1977) The release of prostaglandins from lung and other tissues. Ann NY Acad Sci 180: 363

    Google Scholar 

  77. Rasmussen H, Lake W, Allen J (1975) The effects of catecholamines on rat erythrocytes. Biochim Biophys Acta 411: 63

    Google Scholar 

  78. Reinhertz EL, Weinder HL, Hauser SL, Cohen JH, Weiner HL (1980) Loss of suppressor T cells in active multiple sclerosis. Analysis with monoclonal antibodies. N Engl J Med 303: 125

    Google Scholar 

  79. Rittenhouse-Simmons S (1979) Production of diglyceride from phosphatidylinositol in activated human platelets. J Clin Invest 63: 580

    Google Scholar 

  80. Robertson RP, Little SA (1983) Down regulation of prostaglandin E receptors and homologous desensitization of isolated adipocytes. Endocrinology 113: 1732

    Google Scholar 

  81. Rogers TJ, Campbell L, Calhoun K, Nowoweijski I, Webb DR (1982) Suppression of B cell and T cell responses by the prostaglandin-induced T cell derived suppressor factor (PITS). Cell Immunol 66: 269

    Google Scholar 

  82. Rome LH, Lands WEM (1976) Structural requirements for time dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs. Proc Natl Acad Sci USA 72: 4863

    Google Scholar 

  83. Rose GA, Willden EG (1972) Whole blood, red cell and plasma total and ultrafilterable zinc levels in normal subjects and patients with chronic renal failure with and without hemodialysis. J Neurol 44: 281

    Google Scholar 

  84. Roth GJ, Stanford N, Majerus PW (1975) Acetylation of prostaglandin synthestase by aspirin. Proc Natl Acad Sci USA 72: 30373

    Google Scholar 

  85. Rouzer CA, Scott Wa, Hamill AL, Cohn ZA (1980) Dynamics of leukotriene C production by macrophages. J Exp Med 152: 1236

    Google Scholar 

  86. Russo-Marie F, Duval D (1980) Mechanism of action of glucocorticoids on prostaglandin secretion. In: Ramwell P (ed) Prostaglandin synthetase inhibitors: New clinical applications. Alan R Liss Inc, New York, p 13

    Google Scholar 

  87. Rutherford B, Schenken HA (1983) C3 cleavage products stimulate release of prostaglandins by human mononuclear phagocytes in vitro. J Immunol 130: 874

    Google Scholar 

  88. Sagar HJ, Allonby ID (1979) Lymphocyte subpopulations in multiple sclerosis: Serial studies and clinical correlations. J Neurol Sci 43: 133

    Google Scholar 

  89. Samuelsson B, Hammarstrom S (1982) Leukotrienes: A novel group of biologically active compounds. Vitam Horm 39: 1

    Google Scholar 

  90. Serhan CN, Korchak HM, Weissmann G (1980) PGBX, a prostaglandin derivative, mimics the action of the calcium ionophore A23187 on human neutrophlis. J Immunol 125: 2020

    Google Scholar 

  91. Sheetz MP, Singer SJ (1974) Biological membranes as bilayer couples: A molecular mechanism of drug — erythrocyte interactions. Proc Natl Acal Sci USA 71: 4457

    Google Scholar 

  92. Sinha AK, Colman RW (1978) Prostaglandin E1 inhibits platelet aggregation by a pathway independent of adenosine 31, 51 monophosphate. Science 200: 202

    Google Scholar 

  93. Smith JB, Willis AL (1971) Aspirin selectively inhibits prostaglandin production in human platelets. Nature 231: 235

    Google Scholar 

  94. Smith JW, Steiner AL, Parker CW (1971) Human lymphocyte metabolism. Effects of cyclic and noncyclic nucleotides on stimulation by phytohemagglutinin. J Clin Invest 50: 442

    Google Scholar 

  95. Smolen JS, Chused TM, Novotony EA, Steinberg AD (1982) The human autologous mixed lymphocyte reaction. III. Immune circuits. J Immunol 129: 1050

    Google Scholar 

  96. Snider ME, Fertel RH, Swilling BS (1982) Prostaglandin regulation of macrophage function: Effect of endogenous and exogenous prostaglandins. Cell Immunol 74: 234

    Google Scholar 

  97. Song MK, Adham NF (1979) Evidence for an important role of prostaglandins E2 and F2 in the regulation of zinc transport in rat. Am J Nutr 12: 2152

    Google Scholar 

  98. Stobo JD, Kennedy MS, Goldyne ME (1979) Prostaglandin E modulation of the mitogenic response of human T-cells. J Clin Invest 64: 1188

    Google Scholar 

  99. Synder DS, Beller DI, Unanue ER (1983) Prostaglandins modulate macrophage Ia expression. Nature 299: 163

    Google Scholar 

  100. Takamori M, Komai K, Nitta N, Itouji K (1984) Role of prostaglandin E2 in contractile ionophore A23187. Neurology (NY) 34: 91

    Google Scholar 

  101. Tateson JE, Moncade S, Vane JR (1977) Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets. Prostaglandins 13: 389

    Google Scholar 

  102. Thompson PA, Jelinek DF, Lipsky PE (1984) Regulation of human B-cell proliferation by prostaglandin E2. J Immunol 133: 2446

    Google Scholar 

  103. Traugott U, Reinhertz EL, Raine CS (1983) Multiple sclerosis distribution of T cell subsets within active chronic lesions. Science 219: 308

    Google Scholar 

  104. Utermohlen V, Farmer J, Kornbluth J, Kornstein M (1978) The relationship between direct migration inhibition with measles antigen and E-rosettes in normals and patients with multiple sclerosis. Clin Immunol Immunopathol 9: 63

    Google Scholar 

  105. Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nature 231: 232

    Google Scholar 

  106. Walker C, Kristensen K, Bettens F, de Weck AL (1983) Lymphokine regulation of activated (G1) lymphocytes. Prostaglandin E2-induced inhibitors of interleukin 2 production. J Immunol 130: 1770

    Google Scholar 

  107. Webb DR (1978) The effects of prostaglandins on cAMP levels in subpopulations of mouse lymphocytes. Prostaglandins Medi 1: 441

    Google Scholar 

  108. Webb DR, Nowowiejski I, Heuly C, Rogers TJ (1982) Immunosuppressive properties of leurotriene D4 and E4 in vitro. Biochem Biophys Res Commun 104: 1617

    Google Scholar 

  109. Weiner HL, Schocket AL (1979) Lymphocytes in multiple sclerosis: Correlation with CSF immunoglobulins and cold-reactive lymphocytoxic antibodies. Neurology (NY) 29: 1504

    Google Scholar 

  110. Weiner HL, Bhan A, Burkes J, Gilles F, Kerr C, Rheinhertz E, Hauser SL (1984) Immunochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Neurology (NY) 34: 112

    Google Scholar 

  111. Whisler RL, Newhouse YG (1982) Inhibition of human B lymphocyte colony responses by endogeneously synthesized hydrogen peroxide and prostaglandins. Cell Immunol 69: 34

    Google Scholar 

  112. Willoughby EW, Dupont B, Good RA (1979) Prostaglandin effect on lymphokine production in multiple sclerosis. Ann Neurol 5: 391

    Google Scholar 

  113. Yin HH, Ukena TE, Berlin RD (1972) Effect of Colchicine, colcimed, and vinblastine on the agglutination by concanavalin A of transformed cells. Science 178: 867

    Google Scholar 

  114. Zimecki M, Webb DR (1976) The regulation of the immune response to T independent antigens by prostaglandins and B cells. J Immunol 117: 2158

    Google Scholar 

  115. Zurier RB (1974) Prostaglandins, inflammation and asthma. Arch Intern Med 133: 101

    Google Scholar 

  116. Zurier RB, Weissman G, Hoffstein S, Kammerman S, Jai HH (1974) Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP autonomic agonists and agents which effect microtubule function. J Clin Invest 53: 297

    Google Scholar 

  117. Zurier RB, Dore-Duffy P, Viola MV (1977) Adherence of human peripheral blood lymphocytes to measles-infected cells. Enhancement by prostaglandin E. N Engl J Med 296: 1443

    Google Scholar 

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  1. Division of Neuroimmunology, Multiple Sclerosis Center, Department of Neurology, University of Connecticut Health Center, 06032, Farmington, Connecticut, USA

    Paula Dore-Duffy, Shih-Yieh Ho & Michael Longo

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Dore-Duffy, P., Ho, SY. & Longo, M. The role of prostaglandins in altered leukocyte function in multiple sclerosis. Springer Semin Immunopathol 8, 305–319 (1985). https://doi.org/10.1007/BF00197302

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