Skip to main content
Log in

Species-specificity and localization of encephalitogenic sites in myelin basic protein

  • Published:
Springer Seminars in Immunopathology Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Alvord EC, Jr, Shaw CM, Hruby S, Petersen R, Harvey FH (1975) Correlation of delayed skin hypersensitivity and experimental allergic encephalomyelitis induced by synthetic peptides. In: Tower DB (ed) The nervous system, Vol. 1. The basic neurosciences. Brady RO (ed) Raven Press, New York, p 647

    Google Scholar 

  2. Alvord EC Jr (1984) Species-restricted encephalitogenic determinants. In Alvord EC Jr, Kies MW, Suckling AJ (eds) Experimental allergic encephalomyelitis: A useful model for multiple sclerosis. Alan R. Liss, New York, p 523

    Google Scholar 

  3. Bergstrand H (1972) Encephalitogenic activity in rabbits of the C-terminal region of bovine myelin basic protein: Localization to two different regions. FEBS Lett 23: 195

    Google Scholar 

  4. Bergstrand H (1976) Encephalitogenic activity of the N-terminal part of bovine myelin basic protein in rabbits. Acta Pathol Microbiol Scand [C] 84: 442

    Google Scholar 

  5. Bergstrand H (1977) Immunochemistry of encephalitogenic protein. In: Atassi MZ (ed) Immunochemistry of proteins, Vol. 1. Plenum Press, New York, p 315

    Google Scholar 

  6. Bergstrand H, Källén B (1973) Antigenic determinants on bovine encephalitogenic protein: Studies in rabbits with derivatives of fragment 1–43 and the lymph node cell transformation test, Neurobiol 3: 246

    Google Scholar 

  7. Bernard CCA, Carnegie PR (1975) Experimental autoimmune encephalomyelitis in mice: Immunologic response to mouse spinal cord and myelin basic proteins. J Immunol 114: 1537

    Google Scholar 

  8. Brostoff SW, Reuter W, Hichens M, Eylar EH (1974) Specific cleavage of the A1 protein from myelin with cathepsin D. J Biol Chem 249: 559

    Google Scholar 

  9. Carnegie PR (1969) Digestion of an Arg-Pro bond by trypsin in the encephalitogenic basic protein of human myelin. Nature 223: 958

    Google Scholar 

  10. Chou C-HJ, Fritz RB, Chou FC-H, Kibler RF (1979) The immune response of Lewis rats to peptide 68–88 of guinea pig myelin basic protein. I. T cell determinants. J Immunol 123: 1540

    Google Scholar 

  11. Chou C-HJ, Shapira R, Fritz RB (1983) Encephalitogenic activity of the small form of mouse myelin basic protein in the SJL/J mouse. J Immunol 130: 2183

    Google Scholar 

  12. Chou C-HJ, Shapira R, Fritz RB (1984) Further delineation of encephalitogenic determinant for PL/J and (SJ×PL) F1 mice. In: Alvord EC Jr, Kies MW, Suckling AJ (eds) Experimental allergic encephalomyelitis: A useful model for multiple sclerosis. Alan R. Liss, New York, p 229

    Google Scholar 

  13. Deibler GE, Nomura K, Kies MW (1982) Limited digestion of guinea pig myelin basic protein and its carboxy-terminal fragment (residues 89–169) with Staphylococcus aureus V8 protease. J Neurochem 39: 1090

    Google Scholar 

  14. Deibler GE, Boyd LF, Bacon ML, Driscoll BF, Kies MW (1983) Purification by HPLC of a large peptic fragment of myelin basic protein. Neurochem Pathol 1: 1

    Google Scholar 

  15. Driscoll BF, Kies MW, Alvord EC Jr (1976) Protection against experimental allergic encephalomyelitis with peptides derived from myelin basic protein: Presence of intact encephalitogenic site is essential. J Immunol 117: 110

    Google Scholar 

  16. Eylar EH, Hashim GA (1968) Allergic encephalomyelitis: The structure of the encephalitogenic determinant. Proc Natl Acad Sci USA 61: 644

    Google Scholar 

  17. Eylar EH, Caccam J, Jackson J, Westall FC, Robinson AB (1970) Experimental allergic encephalomyelitis: Synthesis of disease-inducing site of the basic protein. Science 168: 1220

    Google Scholar 

  18. Eylar EH, Westall FC, Brostoff S (1971) Allergic encephalomyelitis: Isolation of an encephalitogenic peptide. J Biol Chem 246: 3418

    Google Scholar 

  19. Eylar EH, Brostoff S, Jackson J, Carter H (1972) Allergic encephalomyelitis in monkeys induced by a peptide from the A1 protein. Proc Natl Acad Sci USA 69: 617

    Google Scholar 

  20. Fritz RB, Chou C-HJ, McFarlin DE (1983) Induction of experimental allergic encephalomyelitis in PL/J and (SJL/J×PL/J)F1 mice by myelin basic protein and its peptides: Localization of a second encephalitogenic determinant. J Immunol 130: 191

    Google Scholar 

  21. Kibler RF, Re' PK, McKneally S, Shapira R (1972) Biological activity of an encephalitogenic fragment in the monkey. J Biol Chem 247: 969

    Google Scholar 

  22. Kies MW (1982) Myelin basic protein. Scand J Immunol 15: 125

    Google Scholar 

  23. Kies MW, Driscoll BF (1982) Immunologic reactivity of myelin basic protein (BP) in inbred guinea pigs. In: Peeters H (ed) Protides of the biologic fluids Proceedings of the Thirtieth Colloquium, Vol. 30. Pergamon Press, New York, p 115

    Google Scholar 

  24. Kies MW, Driscoll BF, Lisak RP, Alvord EC Jr (1975) Immunologic activity of myelin basic protein in strain 2 and strain 13 guinea pigs. J Immunol 115: 75

    Google Scholar 

  25. Kira J, Bacon ML, Kies MW, Alvord EC Jr (1985) Two sites in myelin basic protein encephalitogenic for rabbits. Trans Am Soc Neurochem 16: 128

    Google Scholar 

  26. Kira J, Deibler GE, Krutzsch HC, Martenson RE (1985) Amino acid sequence of porcine myelin basic protein. J Neurochem 44: 134

    Google Scholar 

  27. Lennon VA, Wilks AV, Carnegie PR (1970) Immunologic properties of the main encephalitogenic peptide from the basic protein of human myelin. J Immunol 105: 1223

    Google Scholar 

  28. Martenson RE, Deibler GE, Kies MW (1969) Extraction of rat myelin basic protein free of other basic proteins of whole central nervous system tissue. An analysis of its electrophoretic heterogeneity. J Biol Chem 244: 4268

    Google Scholar 

  29. Martenson RE, Deibler GE, Kies MW, Levine S, Alvord EC Jr (1972) Myelin basic proteins of mammalian and submammalian vertebrates: Encephalitogenic activities in guinea pigs and rats. J Immunol 109: 262

    Google Scholar 

  30. Martenson RE, Deibler GE, Kies MW, McKneally SS, Shapira R, Kibler RF (1972) Differences between the two myelin basic proteins of the rat central nervous system. A deletion in the smaller protein. Biochim Biophys Acta 263: 193

    Google Scholar 

  31. Martenson RE, Nomura K, Levine S, Sowinski R (1977) Experimental allergic encephalomyelitis in the Lewis rat: Further delineation of active sites in guinea pig and bovine myelin basic proteins. J Immunol 118: 1280

    Google Scholar 

  32. McDermott JR, Caspary EA (1975) A comparison of the encephalitogenic activities of human myelin basic protein and the synthetic peptide determinant comprising residues 114–122. J Neurochem 25: 711

    Google Scholar 

  33. McFarlin DE, Blank SE, Kibler RF, McKneally S, Shapira R (1973) Experimental allergic encephalomyelitis in the rat: Response to encephalitogenic proteins and peptides. Science 179: 478

    Google Scholar 

  34. Pettinelli CB, Fritz RB, Chou C-HJ, McFarlin DE (1982) Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse. J Immunol 129: 1209

    Google Scholar 

  35. Shapira R, Chou FC-H, McKneally S, Urban E, Kibler RF (1971) Biological activity and synthesis of an encephalitogenic determinant. Science 173: 736

    Google Scholar 

  36. Stone SH, Lerner EM II, Goode JH Jr (1969) Acute and chronic autoimmune encephalomyelitis: Age, strain, and sex dependency. The importance of the source of antigen. Proc Soc Exp Biol Med 132: 341

    Google Scholar 

  37. Swanborg RH (1975) Antigen-induced inhibition of experimental allergic encephalomyelitis. III. Localization of an inhibitory site distinct from the major encephalitogenic determinant of myelin basic protein. J Immunol 114: 191

    Google Scholar 

  38. Westall FC, Thompson M (1977) Further definition of the encephalitogenic region for guinea pigs. Immunol Commun 6: 23

    Google Scholar 

  39. Westall FC, Thompson M (1977) Encephalitogenic regions for the Lewis rat within the myelin basic protein. Immunol Commun 6: 13

    Google Scholar 

  40. Westall FC, Thompson M (1978) An encephalitogenic region for rabbits. Immunochemistry 15: 189

    Google Scholar 

  41. Westall FC, Robinson AB, Caccam J, Jackson J, Eylar EH (1971) Essential chemical requirements for induction of allergic encephalomyelitis. Nature 229: 22

    Google Scholar 

  42. Young JD, Tsuchiya D, Geier M, Geier S, Westall FC, Thompson M, Cyr R, Ward E, Yorochko F (1974) The encephalitogenic dose response in guinea pigs of the tryptophan region of myelin basic protein. Immunol Commun 3: 219

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kies, M.W. Species-specificity and localization of encephalitogenic sites in myelin basic protein. Springer Semin Immunopathol 8, 295–303 (1985). https://doi.org/10.1007/BF00197301

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00197301

Keywords

Navigation