Conclusion
Consideration of the clinical, pathological and immunological features in PM reveals that a variety of immunological processes, both cellular and humoral, are occurring and may produce widespread damage to other organs as well as skeletal muscle. The basis for the disorder appears to be a failure of immune regulation, most likely associated with a genetic susceptibility.
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References
Aarli JA, Lefvert A-K, Tonder O (1981) Thymoma-specific antibodies in sera from patients with myasthenia gravis demonstrated by indirect haemagglutination. J Neuroimmunol 1: 421
Adams RD (1973) The pathogenic substratum of polymyositis. In: Pearson CM, Mostofi FK (eds) The striated muscle. International Academy of Pathology Monograph. Williams and Wilkins, Baltimore, p 292
Aharanov A, Abramsky O, Tarrab-Hazdai R, Fuchs S (1975) Humoral antibodies to acetylcholine receptor in patients with myasthenia gravis. Lancet 2: 340
Alexander CB, Croker BP, Bosson EH (1982) Dermatomyositis associated with IgA deposition. Arch Pathol Lab Med 106: 449
Amman AJ (1977) Immunodeficiency disorders and autoimmunity. In: Talal N (ed) Autoimmunity. Academic Press, New York, London, p 479
Anderson BA, Young V, Kean WF, Ludwin SK, Galbraith PR, Anastassiades TP (1982) Polymyositis in chronic graft versus host disease. Arch Neurol 39: 188
Ansell BM (1984) Management of polymyositis and dermatomyositis. Clin Rheum Dis 60: 205
Arahata K, Engel AG (1984) Monoclonal antibody analysis of mononuclear cells in myopathies. I: Quantitation of subsets according to diagnosis and sites of accumulation and demonstration and counts of muscle fibres invaded by T cells. Ann Neurol 16: 193
Arnason BGW, Asbury AK (1968) Idiopathic polyneuritis after surgery. Arch Neurol 18: 500
Arnett FC, Hirsch TJ, Bias WB, Nishikai M, Reichlin M (1981) The Jo-1 antibody system in myositis: Relationships to clinical features and HLA. J Rheumatol 8: 925
Arundell FD, Wilkinson RD, Haserick JR (1960) Dermatomyositis and malignant neoplasms in adults. Arch Dermatol 82: 772
Askari AD, Huettner TL, (1982) Cardiac abnormalities in polymyositis/dermatomyositis. Semin Arthritis Rheum 12: 208
Banker BQ (1962) Dermatomyositis of childhood. Trans Am Neurol Assoc 87: 11
Banker BQ (1975) Dermatomyositis of childhood: Ultrastructural alterations of muscle and intramuscular blood vessels. J Neuropathol Exp Neurol 34: 46
Barnes BE (1976) Dermatomyositis and malignancy. A review of the literature. Ann Intern Med 84: 68
Behan PO (1978) Thymectomy in idiopathic polymyositis. Ir J Med Sci 147: 159
Behan WMH, Behan PO, Simpson JA (1975) Absence of cellular hypersensitivity to muscle and thymic antigens in myasthenia gravis. J Neurol Neurosurg Psychiatry 38: 1039
Behan WMH, Behan PO, Dick HA (1978) HLA-8 in polymyositis. N Engl J Med 298: 1260
Behan WMH, Behan PO (1980) A comparison between human polymyositis and the putative animal model experimental allergic myositis. In: Rose FC, Behan PO (eds) Animal models of neurological diseases. Pitman Medical, Tunbridge Wells, p 72
Behan WMH, Barkas T, Behan PO (1982) Detection of immune complexes in polymyositis. Acta Neurol Scand 65: 32
Behan WMH, Behan PO, Doyle D (1982) Association of myasthenia gravis and polymyositis with neoplasia infection and autoimmune disorders. Acta Neuropathol (Berl) 57: 221
Behan WMH, Behan PO, Draper I, Williams H (1983) Does toxoplasma cause polymyositis? Acta Neuropathol (Berl) 61: 246
Behan WMH, Behan PO, Micklem HS, Durward WF (1983) Lymphocyte subset abnormalities in polymyositis. Br Med J 287: 181
Behan WMH, Behan PO (1984) Disturbance of regulatory lymphocyte subsets in polymyositis. Ann Neurol 15: 112
Bernstein RM, Morgan SH, Chapman J, Bunn CC, Mathews MB, Turner-Warwick M, Hughes GRV (1984) Anti-Jo-1 antibody: A marker for myositis with interstitial lung disease. Br Med J 289: 151
Bohan A, Peter JB (1975) Polymyositis and dermatomyositis. Parts I & II. N Engl J Med 291: 344, 292: 403
Bohan A, Peter JB, Bowman RL, Pearson CM (1972) A computer assisted analysis of 153 patients with polymyositis and dermatomyositis. Medicine 56: 255
Bottazzo GF, Bujol-Borrell R, Hanafusa T (1983) Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 11: 1115
Boylan RC, Sokoloff L (1980) Vascular lesions in dermatomyositis. Arthritis Rheum 3: 379
Bresnan MJ, Hauser SL, Weiner JL, Reinherz E, Borel Y, Bhan A (1981) Characterization of T-cell subsets in peripheral blood and muscle in childhood dermatomyositis (Abstr). Ann Neurol 10: 283
Compston DAS, Vincent A, Newsom-Davis J, Batchelor JR (1980) Clinical, pathological, HLA-antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 103: 579
Cumming WJK, Hudgson P, Lattimer D, Sussman M, Wilcox CB (1977) HLA and serum complement in polymyositis. Lancet 2: 978
Dau PC (1981) Plasmapheresis in idiopathic inflammatory myopathy. Arch Neurol 38: 544
Denbow CE, Lie JT, Tancredi RG, Bunch TW (1979) Cardiac involvement in polymyositis. Arthritis Rheum 22: 1088
De Vries S (1951) Retinopathy in dermatomyositis. Arch Ophthalmol 46: 432
De Vere R, Bradley WG (1975) Polymyositis: Its presentation, morbidity and mortality. Brain 98: 637
Dietzman DE, Schaller JG, Ray CG (1976) Acute myositis associated with influenza B infection. Pediatrics 57: 255
Doniach D, Florin-Christensen A (1975) Autoimmunity in the pathogenesis of endocrine exophthalmos. Clin Endocrinol Metab 4: 341
Doyle D, McCurley TL, Sergent JS (1983) Fatal polymyositis in D-penicillamine-treated rheumatoid arthritis. Ann Intern Med 98: 327
Duncan PE, Griffin JP, Garcia A, Kaplan JB (1974) Fibrosing alveolitis in polymyositis: A review of histologically confirmed cases. Am J Med 57: 621
Dyck RF, Katz A, Gordon DA, Johnson M, Shainhouse Z, Cardella CJ, Bear RA (1979) Glomerulonephritis associated with polymyositis. J Rheumatol 6: 336
Ehrengut W (1978) Dermatomyositis and vaccination. Lancet 1: 1040
Engel AG, Arahata K (1984) Monoclonal antibody analysis of mononuclear cells in myopathies. II. Phenotypes of autoinvasive cells in polymyositis and inclusion body myositis. Ann Neurol 16: 29
Engel AG, Biesecker G (1982) Complement activation in muscle fibre necrosis: Demonstration of the membrane attack complex of complement in necrotic fibres. Ann Neurol 12: 289
Fui NT, Teoh R, Houston JC (1981) Polymyositis associated with Hodgkin's disease. Postgrad Med J 57: 526
Fulthorpe JT, Hudgson P (1982) Immunocytochemical localization of immunoglobulins in the inflammatory lesions of polymyositis. J Neuroimmunol 2: 145
Gamboa ET, Eastwood AB, Hays AP, Maxwell J, Penn AS (1979) Isolation of influenza virus from muscle in myoglobulinuric polymyositis. Neurology (Minneap) 29: 1323
Geha RS, Rosen FS (1983) Immunoregulatory T-cell defects. Immunology Today 4: 233
Giorno R, Barden MT, Kohler PF, Ringel SP (1984) Immunohistochemical characterization of the mononuclear cells infiltrating muscle of patients with inflammatory and non-inflammatory myopathies. Clin Immunol Immunopathol 3: 45
Goldfischer J, Rubin EH (1959) Dermatomyositis with pulmonary lesions. Ann Intern Med 50: 194
Gonzalez-Angulo, Fraga A, Mintz G (1968) Submicroscopic alterations in capillaries of skeletal muscles in polymyositis. Am J Med 45: 873
Gotoff SP, Smith RD, Sugar O (1972) Dermatomyositis with cerebral vasculitis in a patient with agammaglobulinaemia. Am J Dis Child 123: 53
Gottdiener JS, Sherber HS, Hawley RJ, Engel WK (1978) Cardiac manifestations in polymyositis. Am J Cardiol 41: 1141
Grace DT, Dao TL (1959) Dermatomyositis in cancer: A possible aetiological mechanism. Cancer 12: 648
Guilliano VJ, (1974) Polymyositis in a patient with acquired hypogammaglobulinaemia. Am J Med Sci 268: 53
Haas DC (1980) Absence of cell-mediated cytotoxicity to muscle cultures in polymyositis. J Rheumatol 7: 671
Haas DC, Arnason BGW (1974) Cell-mediated immunity in polymyositis. Creatine phosphokinase release from muscle cultures. Arch Neurol 31: 192
Hanissian AS, Martinez AJ, Jabbour JT, Duenas DA (1973) Vasculitis and myositis secondary to rubella vaccination. Arch Neurol 28: 202
Heffner RR, Barron SA, Jenis FH, Valeski JC (1976) Skeletal muscles in polymyositis. Immunohistochemical study. Arch Pathol Lab Med 103: 310
Henderson A, Cumming WJK, Williams DO, Hudgson P (1980) Cardiac complications of polymyositis. J Neurol Sci 47: 425
Henriksson KG, Hallert C, Norrby K, Walan A (1982) Polymyositis and adult coeliac disease. Acta Neurol Scand 65: 301
Hirsch TJ, Ollard K, Enlow RW, Bias WB, Arnett FC Jr (1979) HLA-A, B, C and DRw antigens in dermato- and polymyositis. Arthritis Rheum 22: 622
Hubbard WN, Walport MJ, Halnan KE, Beaney RP, Hughes GRV (1982) Remission from polymyositis after total body irradiation. Br Med J 284: 1915
Hudgson P (1984) Polymyositis and dermatomyositis in adults. Clin Rheum Dis 10: 85
Hughes JT, Esiri MM (1975) Ultrastructural studies in human polymyositis. J Neurol Sci 25: 347
Isenberg DA (1983) Immunoglobulin deposition in skeletal muscle in primary muscle disease. Q J Med 52: 297
Isenberg DA (1984) Myositis in other connective tissue disorders. Clin Rheum Dis 10: 151
Isenberg DA, McKean RO (1982) A study of vascular permeability in normal skeletal muscle and inflammatory myopathies using a fluorescein dye technique with percutaneous needle biopsy. J Neurol Sci 53: 423
Iyer V, Lawton AR, Fenichel GM (1983) T-cell subsets in polymyositis. Ann Neurol 13: 452
Iyer V, Lawton AR, Fenichel GM (1984) (Reply) Ann Neurol 15: 114
Janis JF, Winkelmann RK (1968) Histopathology of the skin in dermatomyositis. Arch Dermatol 97: 640
Jerusalem F, Rakusa M, Engel AG, Macdonald RD (1974) Morphometric analysis of skeletal muscle capillary ultrastructure in inflammatory myopathies. J Neurol Sci 23: 391
Johnson MP, Bear R, Katz A, Shainhouse Z (1975) Glomerulonephritis associated with myoglobulinaemia. Kidney Int 8: 413
Kaas E, Straume S, Mellbye OJ, Munthe E, Solheim BG (1979) Dermatomyositis associated with BCG vaccination. Scand J Rheumatol 8: 187
Kantor RJ, Norden CW, Weir TP (1978) Infectious mononucleosis associated with rhabdomyolysis and renal failure. South Med J 71: 346
Katz DH (1983) Genetic controls and cellular interactions in antibody formation. In: Dixon FJ, Fisher DW (eds) The biology of immunologic disease. Sinauer Associates, Sunderland, p 25
Keitzmann A, Welke S, Preissner CW, Gross WL (1984) Fulminant course of dermatomyositis. Cyclosporin A treatment. Aktuel Dermatol 10: 114
King ML, Birdwell D, Shaikh A, Voler A, Banatvala JE (1983) Coxsackie B virus-specific IgM response in children with insulin-dependent (juvenile onset: Type 1) diabetes mellitus. Lancet 1: 1397
Kolb H, Toyka K (1983) Humoral or cellular effector mechanisms? Immunology Today 4: 332
Kong YM (1983) T-cell balance in organ targets. Immunology Today 4: 304
Lambie JA, Duff IF (1963) Familial occurrence of dermatomyositis. Ann Intern Med 59: 839
Leddy JP, Griggs RC, Klemperer MR, Frank MM (1975) Hereditary complement (C2) deficiency with dermatomyositis. Am J Med 58: 83
Levinsky RJ (1981) Role of circulating immune complexes in renal disease. J Clin Pathol 34: 1214
Levy R, Kaplan HS (1974) Impaired lymphocyte function in unstreated Hodgkin's disease. N Engl J Med 290: 181
Lewkonia RM, Buxton PH (1973) Myositis in father and daughter. J Neurol Neurosurg Psychiatry 36: 820
Lisak RP, Zweiman B (1975) Mitogen and muscle extract induced in vitro proliferative responses in myasthenia gravis, dermatomyositis and polymyositis. J Neurol Neurosurg Psychiatry 38: 521
Lisak RP, Zweiman B (1976) Serum immunoglobulin levels in myasthenia gravis, polymyositis and dermatomyositis. J Neurol Neurosurg Psychiatry 39: 34
Lisak RP, Mercado F, Zweiman B (1979) Cold reactive antilymphocyte antibodies in neurological disease. J Neurol Neurosurg Psychiatry 42: 1054
Lisak RP, Zweiman B, Sholnik P, Guerrero F (1984) (Abstr) Circulating T-cell subsets in inflammatory myopathies. Neurology 34: Suppl 1, 191
Lisman JV (1947) Dermatomyositis with retinopathy. Arch Ophthalmol 37: 135
Litsey SE, Noonan JA, O'Connor WN, Cottrill CM, Mitchell B (1985) Maternal connective tissue disease and congenital heart block: Demonstration of immunoglobulin in cardiac tissue. N Engl J Med 312: 98
Lynch PG (1971) Cardiac involvement in chronic polymyositis. Br Heart J 33: 416
Magid SK, Kagen LJ (1983) Serologic evidence for acute toxoplasmosis in polymyositis and dermatomyositis. Am J Med 75: 313
Mastaglia FL (1980) Drug-induced disorders of muscle. Br J Hosp Med 24: 8
Mastaglia F, Currie S (1971) Immunological and ultrastructural observations on the role of lymphoid cells in the pathogenesis of polymyositis. Acta Neuropathol (Berl) 18: 1
Masters CL, Dawkins RL, Zilko PJ, Simpson JA, Leedman RJ, Lindstrom J (1977) Penicillamine-associated myasthenia gravis, anti-acetylcholine receptor and anti-striational antibodies. Am J Med 63: 689
Mathews MB, Bernstein RM (1983) Myositis autoantibody inhibits histidyl -tRNA synthetase: A model for autoimmunity. Nature 304: 177
Menzies CB, Gunar M, Thomas DG, Behan PO (1980) Impaired thymus-derived lymphocyte function in patients with malignant brain tumour. Clin Neurol Neurosurg 82: 157
Mihas AA, Kirby D, Kent SP (1978) Hepatitis B antigen and polymyositis. JAMA 239: 221
Morgan BP, Sewry CA, Siddle K, Luzio JP, Campbell AK (1984) Immunolocalization of complement component C9 on necrotic and non-necrotic muscle fibres in myositis using monoclonal antibodies: A primary role of complement in autoimmune cell damage. Immunology 52: 181
Moutsopoulos H, Fye KH (1975) Lipoid nephrosis and focal glomerulonephritis in a patient with polymyositis. Lancet 1: 139
Munsat T, Cancilla P (1974) Polymyositis without inflammation. Bull Los Angeles Neurol Soc 39: 113
Nesbitt LT (1980) Cutaneous immunofluorescence in dermatomyositis. Int J Dermatol 19: 270
Nishikai M, Homma M (1977) Circulating autoantibody against human myoglobin in polymyositis. JAMA 237: 1842
Nishikai M, Reichlin M (1980) Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis. Arthritis Rheum 23: 881
Nishikai M, Funatsu Y, Homma M (1974) Monoclonal gammopathy, penicillamine-induced polymyositis and systemic sclerosis. Arch Dermatol 110: 253
Oka M, Raasakka T (1978) Cardiac involvement in polymyositis. Scand J Rheumatol 7: 203
Oxenhandler R, Adelstein EH, Hart MN (1977) The value of direct immunofluorescence in the diagnosis of connective tissue disease. Hum Pathol 8: 321
Pachman LM, Cooke N (1980) Juvenile dermatomyositis: A clinical and immunologic study. J Pediatr 96: 226
Page AR, Hansen AE, Good RA (1963) Occurrence of leukemia and lymphoma in patients with agammaglobulinaemia. Blood 21: 197
Pagel W, Treip CS (1955) Viscero-cutaneous collagenosis. J Clin Pathol 8: 1
Paty JG, Sienknecht CW, Townes AS, Hanissian AS, Muller JB, Masi AT (1975) Impaired cell-mediated immunity in systemic lupus erythematosus (SLE). Am J Med 59: 769
Pauly JL, Sokol JE, Han R (1973) Whole blood culture technique for functional studies of lymphocyte reactivity to mitogens, antigens and homologous lymphocytes. J Clin Med 82: 500
Pearson CM (1975) Myopathy with viral-like structures. N Engl J Med 292: 641
Peck SM (1966) Bullous pemphigoid with polymyositis and coexisting contact dermatitis. Arch Dermatol 94: 672
Penn AS, Schotland DL, Rowland LP (1971) Immunology of muscle disease. In: Rowland LP (ed) Immunological disorders of the nervous system. Williams and Wilkins Co, Baltimore, p 215
Pier N, Dubowitz V (1983) Chronic graft versus host disease presenting with polymyositis. Br Med J 286: 2024
Poser CM, Behan PO (1982) Late onset of Guillain-Barre syndrome. J Neuroimmunol 3: 27
Provost TT, Arnett FC, Reichlin M (1983) Homozygous C2 deficiency, lupus erythematosus and anti-Ro antibodies. Arthritis Rheum 6: 1279
Ransohoff RM, Dustoor MM (1983) Impaired autologous mixed lymphocyte reaction with normal concanavalin A-induced suppression in adult polymyositis/dermatomyositis. Clin Exp Immunol 53: 67
Riddoch D, Morgan-Hughes JA (1975) Prognosis in adult polymyositis. J Neurol Sci 26: 71
Ringel SP, Thorne G, Phanuphak P, Lara NS, Kohler PS (1979) Immune complex vasculitis polymyositis, and hyperglobulinemic purpura. Neurology (NY) 29: 682
Rodnan GP (1961) The pathogenesis of progressive systemic sclerosis (diffuse scleroderma) and dermatomyositis. In: Mills LC, Moyer JH (eds) Inflammation and diseases of connective tissue, A Hahnemann Symposium. Saunders, Philadelphia, p 225
Rose JDG (1979) Membranous glomerulonephritis, dermatomyositis and bronchial carcinoma. Br Med J 111: 641
Rowe DJ, Isenberg DA, McDougall J, Beverley PCL (1981) Characterization of polymyositis infiltrates using monoclonal antibodies to human leucocyte antigens. Clin Exp Immunol 45: 290
Salmeron G, Greenberg SD, Lidsky MD (1981) Polymyositis and diffuse interstitial lung disease. A review of pulmonary histopathology findings. Arch Intern Med 141: 15
Sammartino A, Lucariello A, Esposito L, Coluccino V, Loffredo A (1981) A rare presentation of bilateral membranous conjunctivitis in dermatomyositis in young age. J Pediatr Ophthalmol Strabismus 18: 47
Sato T, Chou S-M (1978) Effect of denervation on Coxsackie A virus myositis in mice: An electron microscopic study. Neurology (NY) 28: 1232
Schaller JG, Hansen JA (1983) HLA relationships to disease. In: Dixon FJ, Fisher DW (eds) The biology of immunologic disease. Sinauer Associates, Sunderland, p 177
Schatz M, Patterson R, Fink J (1979) Immunologic lung disease. N Engl J Med 300: 1310
Schaumburg HH, Nielsen SL, Yurchak PM (1971) Heart block in polymyositis. N Engl J Med 284: 480
Schwarz MI, Matthay RA, Sahn SA, Stanford RE, Marmorstein BL, Scheinhorn DJ (1976) Interstitial lung disease in polymyositis and dermatomyositis: Analysis of six cases and review of the literature. Medicine 55: 89
Scott JS, Maddison PJ, Taylor PV, Esschar E, Scott O, Skinner P (1983) Connective tissue disease, antibodies to ribonucleoprotein and congenital heart disease. N Engl J Med 309: 209
Shulman LE, Sullivan KM, Weiden PL (1980) Chronic graft-versus-host syndrome in man. Am J Med 69: 204
Siguier F, Binet J-P, Godeau P, Levy R, Hamida B (1962) Dermatomyosite compliquee de bloc auriculo-ventriculaire complet avec syndrome d'Adams-Stokes. Bull Mem Soc Med Paris 113: 1126
Slling J, Slling K, Jacobsen KU (1979) Circulating immune complexes in lupus erythematosus, scleroderma and dermatomyositis. Acta Derm Venereol (Stockh) 59: 421
Smith PR, Venables PJW, Williams D, Maini RN (1984) Identification and purification of a 55 K polypeptide in Sjogren's syndrome A antigen. Rheumatol Int 4: 135
Souadjian JV, Enriquez P, Silverstein MN, Pepin J-M (1974) The spectrum of diseases associated wuth thymoma. Coincidence or syndrome? Arch Intern Med 134: 374
Susac JO, Garcia-Mullin R, Glaser JS (1973) Ophthalmoplegia in dermatomyositis. Neurology (NY) 23: 305
Tan EM (1982) Autoantibodies to nuclear antigens (ANA): Their immunobiology and medicine. Adv Immunol 33: 167
Tang TT, Sedmak GV, Siegsmund KA, McCreadie SR (1975) Chronic myopathy associated with Coxsackie virus type A9. N Engl J Med 292: 608
Toh BH (1979) Smooth muscle autoantibodies and autoantigens. Clin Exp Immunol 38: 621
Travers RL, Hughes GRV, Cambridge G, Sewell JR (1977) Coxsackie B neutralization titres in polymyositis/dermatomyositis. Lancet 1: 1268
Treves R, Tabaraud F, Arnaud M, Jacob P, Hugon J, Lubeau M, Burki F, Desproges-Gotteron R (1984) Polymosite aïgue compliquant une polyarthrite traitée a la pyrithioxine. Rev Rhum Mal Osteoartic 51: 283
Venables PJW, Mumford PA, Maini RM (1981) Antibodies to nuclear antigens in polymyositis: Relationship to autoimmune “overlap syndromes” and carcinoma. Ann Rheum Dis 40: 217
Walker GL, Mastaglia FL, Roberts DF (1982) A search for a genetic influence in idiopathic inflammatory myopathy. Acta Neurol Scand 66: 432
Walton JN, Adams RD (1958) Polymyositis. London, Livingstone, Edinburgh
Wang BS, Heacock EH, Wu AUO, Mannick JA (1980) Generation of suppressor cells in mice after surgical trauma. J Clin Invest 66: 20
Watson AJS, Dalbow MH, Stachura I, Fragola JA, Rubin MF, Watson M, Bourke E (1983) Immunologic studies in cimetidine-induced nephropathy and polymyositis. N Engl J Med 308: 142
Wedgewood RJP, Cook CD, Cohen J (1953) Dermatomyositis. (Report of 26 cases in children with a discussion of endocrine therapy in 13). Pediatrics 12: 447
Weiner HL, Hauser SL (1982) Neuroimmunology. I: Immunoregulation in neurological disease. Ann Neurol 11: 437
Whitaker JN (1982) Inflammatory myopathy: A review of etiological and pathogenetic factors. Muscle Nerve 5: 573
Whitaker JN, Engel WK (1972) Vascular deposits of immunoglobulin and complement in idiopathic inflammatory myopathy. N Engl J Med 286: 334
Wilfert CM, Buckley RH, Mohanakumar T, Griffith JF, Katz SL, Whisnant JK, Eggleston PA, Moore M, Treadwell E, Oxman MN, Rosen FS (1977) Persistent and fatal central-nervous-system echovirus infections in patients with agammaglobulinaemia. N Engl J Med 296: 1485
Winkelmann RK, Jordon RE, de Moragas OM (1972) Immunofluorescent studies of dermatomyositis. Dermatologica 145: 42
Wolin SL, Steitz JA (1984) The Ro small cytoplasmic ribonucleoproteins: Identification of the antigenic protein and its binding site on the Ro RNAs. Proc Natl Acad Sci USA 81: 1996
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Behan, W.M.H., Behan, P.O. Immunological features of polymyositis/dermatomyositis. Springer Semin Immunopathol 8, 267–293 (1985). https://doi.org/10.1007/BF00197300
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DOI: https://doi.org/10.1007/BF00197300