Summary
Orosomucoid (ORM) phenotyping has been performed in 141 families with 407 children from southwest Germany. Eight families were observed in which duplicated ORM1 genes, F1F2, F1F3, segregated. The family data gave no information about the presence of tandemly duplicated ORM1 F1F4 and ORM1 F1F5 genes. To date, the segregation of the phenotypes of the children agrees with the extended formal model: two ORM1 loci with two common (*F1, *S) and several rare (*F1F2, *F1F3, *F4, *F5) alleles. The parental allele frequencies were calculated by gene counting as ORM1 *F1 = 0.5781, *S = 0.3901, *F1F2 = 0.0195, *F4 = 0.0053, *F1F3 = 00.0035, *F5 = 0.0035.
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References
Allen PC, Hill EA, Stokes AM (eds) (1977) Plasma proteins. Analytical and preparative techniques. Blackwell, Oxford London Edinburgh, pp 207–209
Altland K, Banzhoff A, Hackler R, Rossmann U (1984) Improved rehydration procedure for polyacrylamide gels in presence of urea: demonstration of inherited human prealbumin variants by isoelectric focusing in an immobilized pH gradient. Electrophoresis 5:379–381
Dente L, Ciliberto G, Cortese R (1985) Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. Nucleic Acids Res 13:3941–3952
Eap CB, Cuendet C, Baumann P (1988) Orosomucoid (alpha-1 acid glycoprotein) phenotyping by use of immobilized pH gradients with 8mol/l urea and immunoblotting. Hum Genet 80:183–185
Escallon MH, Ferrell RE, Kamboh MJ (1987) Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma. Am J Hum Genet 41:418–427
Johnson AM, Scmid K, Alper CA, Bisset L (1969) Inheritance of human alpha-1 acid glycoprotein (orosomucoid) variants. J Clin Invest 48:2293–2299
Krüger HJ, Edler M, Keil W, Tröger HD (1990) ORM1 subtypes in Hannover and Lower Saxony, FRG, by PAG SIEF and immunoblotting (N = 1934); 11 Variants. Adv Forensic Haemogenet 3:308–312
Luckenbach C, Kömpf J, Ritter H (1989) Improved subtyping of orosomucoid 1 (ORM, alpha-1 acid-glycoprotein). Ärztl Lab 35:192–193
Thymann M, Eiberg H (1986) Orosomucoid polymorphism: determination by separatory isoelectric focusing and demonstration of ORM*F subtypes. Adv Forensic Haemogenet 1:162–166
Thymann M, Weidinger S (1988) Subtyping of orosomucoid 1 (ORM1) by isoelectric focusing in agarose and polyacrylamide gels. Electrophoresis 9:380–383
Weidinger S, Müller T, Schwarzfischer F, Cleve H (1987) Three new orosomucoid (ORM) variants revealed by isoelectric focusing and print immunofixation. Hum Genet 77:286–288
Yuasa J, Umetsu K, Suenaga K, Robinet-Levy M (1986) Orosomucoid (ORM) typing by isoelectric focusing: evidence for two structural loci ORM1 and ORM2. Hum Genet 74:160–161
Yuasa J, Suenaga K, Umetsu K, Ito K, Robinet-Levy M (1987) Orosomucoid (ORM) typing by isoelectric focusing: evidence for gene duplication of ORM1 and genetic polymorphism of ORM2*. Hum Genet 77:255–258
Yuasa J, Umetsu K, Suenaga K (1988) Orosomucoid (ORM) typing by isoelectric focusing: evidence for an additional duplicated ORM1 locus haplotype and close linkage of two ORM loci. Am J Hum Genet 43:165–169
Zischler H, Kömpf J, Ritter H (1987) IEF of Hp-subtypes presentation of population genetic data and variants. Ärztl Lab 33:85–87
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Luckenbach, C., Kömpf, J. & Ritter, H. Orosomucoid (ORM 1) subtyping and formal genetics. Hum Genet 87, 429–432 (1991). https://doi.org/10.1007/BF00197162
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DOI: https://doi.org/10.1007/BF00197162