Skip to main content
Log in

Metabolic profile of atrazine and N-nitrosoatrazine in rat urine

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Adler ID (1980) A review of the coordinated research effort on the comparison of test systems for the detection of mutagenic effects, sponsored by the E.E.C. Mutat. Res. 74:77–93

    Google Scholar 

  • Bagnati R, Benfenati E, Davoli E, Fanelli R (1988) Screening of 21 pesticides in water by single extraction with C18 silica bonded phase columns and HRGC-MS. Chemosphere 17:59–65

    Google Scholar 

  • Bakke JE, Larson JD, Price CE (1972) Metabolism of atrazine and 2-hydroxyatrazine by the rat. J. Agric. Food Chem. 20:602–607

    Google Scholar 

  • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254

    Article  CAS  PubMed  Google Scholar 

  • Foster TS, Khan SU, Akhtar MH (1979) Metabolism of atrazine by the soluble fraction (105000g) from chicken liver homogenates. J. Agric. Food Chem. 27: 300–303

    Google Scholar 

  • Gojmerac T, Kniewald J (1989) Atrazine biodegradation in rats- A model for mammalian metabolism. Bull. Environ. Contam. Toxicol. 43:199–206

    Google Scholar 

  • Janzowsky C, Klein R, Preussmann R (1980) Formation of N-nitroso compounds of the pesticides atrazine, simazine and carbaryl with nitrogen oxides. In: Walker EA, Castegnaro M, Griciute L, Borzsonyi M (Eds) N-Nitroso Compounds: Analysis, Formation and Occurrence, IARC Scientific Publications no. 31. IARC, Lyon, p 329–339

    Google Scholar 

  • Kearney PC, Oliver JE, Helling CS, Isensee AR, Kontson A (1977) Distribution, movement, persistence and metabolism of N-nitrosoatrazine in soils and a model aquatic ecosystem. J. Agric. Food Chem. 25:1177–1181

    Google Scholar 

  • Krull IS, Mills K, Hoffman G, Fine DH (1980) The analysis of N-nitrosoatrazine and N-nitrosocarbaryl in whole mice. J. Anal. Toxicol. 4:260–262

    Google Scholar 

  • Mirvish SS (1975) Formation of N-nitroso compounds: chemistry, kinetics, and in vivo occurrence. Toxicol. Appl. Pharmacol. 31:325–351

    Google Scholar 

  • Pino A, Maura A, Grillo P (1988) DNA damage in stomach, kidney, liver and lung of rats treated with atrazine. Mutat. Res. 209:145–147

    Google Scholar 

  • Pinter A, Török G, Börzsönyi M, Surjan A, Csik M, Kelecsenyi Z, Kocsis Z (1990) Long-term carcinogenicity bioassay of the herbicide atrazine in F344 rats. Neoplasma 37:533–544

    Google Scholar 

  • Rainey WT, Christie WH, Lijinsky W (1978) Mass spectrometry of N-nitrosamines. Biomed. Mass Spectrom. 5:395–408

    Google Scholar 

  • Reinhardt CF, Brittelli MR (1981) Heterocyclic and miscellaneous nitrogen compounds. In: Clayton GD, Clayton FE (Eds) Patty's Industrial Hygiene and Toxicology, 3rd rev. ed., vol 2A. John Wiley and Sons, New York, p 2671–2822

    Google Scholar 

  • Riddles PW, Blakeley RL, Zerner B (1979) Ellman's reagent: 5,5′ dithiobis(2-nitrobenzoic acid) — a reexamination. Anal. Biochem. 94:75–81

    Google Scholar 

  • Ross JA, Tweedy BG (1970) Mass spectra of chloro-,aminochloro- and ethylaminochloro triazines. Organic Mass Spectrometry 3:219–229

    Google Scholar 

  • Timchalk C, Dryzga MD, Langvardt PW, Kastl P.E., Osborne DW (1990) Determination of the effect of tridiphane on the pharmacokinetics of [14 C]-atrazine following oral administration to male fischer 344 rats. Toxicology 61:27–40

    Google Scholar 

  • Weisenburger DD, Joshi SS, Hickman TI, Walker BA, Lawson TA (1988) Mutagenesis tests of atrazine and N-nitrosoatrazine. Compounds of special interest to the Midwest. Proc. Am. Ass. Cancer Res. 29:106

    Google Scholar 

  • Wilson MP, Savage EP, Adrian DD, Aaronson MJ, Keefe TJ, Hamar DH, Tessari JT (1987) Groundwater transport of the herbicide, atrazine. Weld County, Colorado. Bull. Environ. Contam. Toxicol. 39:807–814

    Google Scholar 

  • Wolfe NL, Zepp RG, Gordon JA, Fincher RC (1976) N-nitrosamine formation from atrazine. Bull. Environ. Contam. Toxicol. 15:342–347

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Meli, G., Bagnati, R., Fanelli, R. et al. Metabolic profile of atrazine and N-nitrosoatrazine in rat urine. Bull. Environ. Contam. Toxicol. 48, 701–708 (1992). https://doi.org/10.1007/BF00195990

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00195990

Keywords

Navigation