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Human leukocyte alpha interferon-induced transient neurotoxicity in children

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Summary

Neuropsychiatric complications with recombinant alpha interferon (rIFN-α) have been described in adults. Little documentation of similar toxicity in pediatric phase I and phase II trials exists. Two children, treated with rIFN-α, experienced confusion, somnolence and syncope, associated with transient electroencephalographic abnormalities. Symptoms abated and electroencephalographic findings improved with termination of therapy. Readministration at lower dosages has not been associated with recurrence of neurotoxicity.

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References

  1. Kirkwood JM, Ernstaff MS: Interferons in the treatment of human cancer. J Clin Oncol 2(4): 336–353, 1984

    Google Scholar 

  2. Adams F, Quesada JR, Gutterman JV: Neuropsychiatric manifestations of human leukocyte interferon therapy in patients with cancer. JAMA 252(7): 938–941, 1984

    Google Scholar 

  3. Quesada JR, Talpaz M, Rios A, Kurzrock R, Gutterman JU: Clinical toxicity of interferons in cancer patient: A review. J Clin Oncol 5(2): 234–243, 1986

    Google Scholar 

  4. Spiegel RJ: The Alpha Interferons: Clinical overview. Sem in Oncol 14(2): 1–12, 1987

    Google Scholar 

  5. Rhatiner AS, Prior PF, Burten AC, Smith AT, Balhwill FR, Lister TA: Central nervous system toxicity of interferons. BR J Cancer 47:419–422, 1983

    Google Scholar 

  6. Mattson K, Niiranen A, Livanainen M, Farkkila M, Gergstrom I, Holsti LR: Neurotoxicity of interferon. Cancer Treat Rep 67(10): 958–960, 1983

    Google Scholar 

  7. Smedley H, Katrak M, Sikora K, Wheeler T: Neurological effects of recombinant human interferon. Br Med J 286:262–264, 1983

    Google Scholar 

  8. Suter CC, Westmorland BF, Sharbrough FW, Hermann RC: Electroencephalographic abnormalities in Interferon. Encephalopathy — A preliminary report. Mayo Clin Proc 59:847–850, 1984

    Google Scholar 

  9. Mahoney DH Jr, Britt CW, Kellaway P, Fernbach DJ: Childhood leukemia: Implications of EEG findings at time of diagnosis. J Pediatr 98(3): 437–440, 1981

    Google Scholar 

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Authors and Affiliations

  1. Hematology-Oncology Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

    Julie A. Katz, Donald H. Mahoney, C. Philip Steuber & Donald J. Fernbach

Authors
  1. Julie A. Katz
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  2. Donald H. Mahoney
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  3. C. Philip Steuber
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  4. Donald J. Fernbach
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Additional information

Dr. Katz is the recipient of an American Cancer Society Fellowship Award.

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Katz, J.A., Mahoney, D.H., Steuber, C.P. et al. Human leukocyte alpha interferon-induced transient neurotoxicity in children. Invest New Drugs 6, 115–120 (1988). https://doi.org/10.1007/BF00195369

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  • DOI: https://doi.org/10.1007/BF00195369

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