Skip to main content
Log in

Spontaneous evolution and photocoagulation of diabetic cystoid macular edema

  • Clinical Investigation
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Cystoid macular edema (CME) causes progressive visual impairment in diabetic patients and its treatment by photocoagulation remains unsatisfactory. We observed its spontaneous evolution for 3 years in 31 eyes. CME resolved in 9 eyes, was fluctuant in 16 and worsened in 7. Mean group visual acuity (VA) remained unchanged. Two modalities of photocoagulation were studied. In 27 eyes exhibiting CME combined with circinate exudates (group 1), extramacular focal photocoagulation was applied to the center of the exudates. Exudates disappeared from 23 eyes and CME from 12 eyes. Mean group VA remained unchanged. In 24 eyes with CME but without exudates (group 2), perifoveolar grid photocoagulation was applied over the CME area. CME disappeared from 15 eyes. Mean VA remained unchanged. These results show that CME with exudates requires a two-step treatment, comprising first focal photocoagulation, which clears exudates and often improves CME, and second —but only if CME persists and VA is below 0.5 — perifoveolar grid photocoagulation, which often clears CME and stabilizes VA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Aiello LM, Rand LI, Briones JC, Weiss JN, Wafai MZ (1983) NonocuJar clinical risk factors in the progression of diabetic retinopathy. In: Little HL, Jack RL, Patz A, Forsham PH (eds) Diabetic retinopathy. Thieme-Stratton, New York, pp 21–32

    Google Scholar 

  2. Berger AR, Boniuk I (1989) Bilateral subretinal neovascularization after focal argon laser photocoagulation for diabetic macular edema. Am J Ophthalmol 108:88–90

    Google Scholar 

  3. Blankenship GW (1979) Diabetic macular edema and argon laser photocoagulation: a prospective randomized study. Ophthalmology 86:69–78

    CAS  PubMed  Google Scholar 

  4. Bresnick GH (1983) Diabetic maculopathy. A critical review highlighting diffuse macular edema. Ophthalmology 90:1301–1317

    Google Scholar 

  5. Bresnick GH (1986) Diabetic macular edema. A review. Ophthalmology 93:989–997

    Google Scholar 

  6. British Multicentre Study Group (1983) Photocoagulation for diabetic maculopathy. A randomized controlled clinical trial using the xenon arc. Diabetes 32:1010–1016

    Google Scholar 

  7. Casswell AG, Canning CR, Gregor ZJ (1990) Treatment of diffuse diabetic macular edema: a comparison between argon and krypton lasers. Eye 4:668–672

    Google Scholar 

  8. Chaine G, Gaudric A, Ramioul E, Coscas G (1986) Maculopathie diabétique. Evolution spontanée. Bull Soc Ophtalmol Fr 8–9:993–1000

    Google Scholar 

  9. Coscas G, Gaudric A (1984) Natural course of nonaphakic cystoid macular edema. Surv Ophthalmol [Suppl] 28:471–484

    Google Scholar 

  10. Early Treatment Diabetic Retinopathy Study Research Group (1985) Early Treatment Diabetic Study Report no. 1: photocoagulation for diabetic macular edema. Arch Ophthalmol 103:1796–1806

    PubMed  Google Scholar 

  11. Early Treatment Diabetic Retinopathy Study Research Group (1987) Photocoagulation for diabetic macular edema: Early Treatment Diabetic Retinopathy Study report no. 4. Int Ophthalmol Clin 27:265–272

    Google Scholar 

  12. Early Treatment Diabetic Retinopathy Study Research Group (1987) Treatment techniques and clinical guidelines for photocoagulation of diabetic macular edema: Early Treatment Diabetic Retinopathy Study Report no. 2. Ophthalmology 94:761–774

    Google Scholar 

  13. Early Treatment Diabetic Retinopathy Study Research Group (1991) Early photocoagulation for diabetic retinopathy. Early Treatment Diabetic Retinopathy Study Report no. 9. Ophthalmology 98:766–785

    Google Scholar 

  14. Ferris FL, Patz A (1984) Macular edema. A complication of diabetic retinopathy. Surv Ophthalmol [Suppl] 28:452–461

    Google Scholar 

  15. Gass JDM (1987) Leber's idiopathic stellate neuroretinitis. In: Gass (ed) Stereoscopic atlas of macular diseases: diagnosis and treatment, 3rd edn. Mosby, St Louis, pp 746–751

    Google Scholar 

  16. Gass JDM, Anderson DA, Davis EB (1985) A clinical, fluorescein angiographic, and electron microscopic correlation of cystoid macular edema. Am J Ophthalmol 100:82–86

    Google Scholar 

  17. Gaudric A, Ramioul E, Chaine G, Coscas G (1984) Traitement de l'ædème maculaire cystoïde diabétique par photocoagulation au laser à l'argon. J Fr Ophtalmol 7:291–304

    Google Scholar 

  18. Grey RHB (1986) The treatment of diabetic maculopathy by argon laser photocoagulation. Trans Ophthalmol Soc UK 105:424–429

    Google Scholar 

  19. Haut J, Van Effenterre G, Flamand M, Dureuil J, Cahiza M (1980) Traitement de l'ædème cystoïde maculaire par photocoagulation périfovéolaire au laser à l'argon. Bull Soc Ophtalmol Fr, 80:15–21

    Google Scholar 

  20. Klein R, Klein BEK, Moss SE, Davis MD, DeMets DL (1984) The Wisconsin epidemiologic study of diabetic retinopathy. IV Diabetic macular edema. Ophthalmology 91:1464–1474

    Google Scholar 

  21. Klein R, Moss SE, Klein BEK, Davis MD, DeMets DL (1989) The Wisconsin Epidemiologic Study of diabetic retinopathy. IX. The incidence of macular edema. Ophthalmology 96:1501–1510

    Google Scholar 

  22. Lee CM, Olk RJ (1991) Modified grid laser photocoagulation for diffuse diabetic macular edema. Long-term visual results. Ophthalmology 98:1594–1602

    Google Scholar 

  23. Lewis H, Schachat AP, Haimann MH, Haller JA, Quinlan P, Von Fricken MA, Fine SL, Murphy RP (1990) Choroidal neovascularization after laser photocoagulation for diabetic macular edema. Ophthalmology 97:503–511

    Google Scholar 

  24. Marshall J, Clover G, Rothery S (1984) Some new findings on retinal irradiation by krypton and argon lasers. Doc Ophthalmol Proc Ser 36:21–37

    Google Scholar 

  25. Mc Donald HR, Schatz H (1985) Macular edema following panretinal photocoagulation. Retina 5:5–10

    Google Scholar 

  26. Mc Donald HR, Schatz H (1985) Grid photocoagulation for diffuse macular edema. Retina 5:65–72

    CAS  PubMed  Google Scholar 

  27. Mc Naught EI, Foulds WS, Allan D (1988) Grid photocoagulation improves reading ability in diffuse diabetic macular edema. Eye 2:288–296

    Google Scholar 

  28. Olk RJ (1986) Modified grid argon (blue-green) laser photocoagulation for diffuse diabetic macular edema. Ophthalmology 93:938–950

    CAS  PubMed  Google Scholar 

  29. Olk RJ (1990) Argon green (514 nm) versus krypton red (647 nm) modified grid laser photocoagulation for diffuse diabetic macular edema. Ophthalmology 97:1101–1113

    Google Scholar 

  30. Patz A, Schatz H, Gittelsohn AM, Berkow JW, Ticho U (1973) Macular edema. An overlooked complication of diabetic retinopathy. Trans Am Acad Ophthalmol Otolaryngol 77:34–41

    Google Scholar 

  31. Perkovich BT, Meyers SM (1988) Systemic factors affecting diabetic macular edema. Am J Ophthalmol 105:211–212

    Google Scholar 

  32. Pugesgaard T, Laursen AB (1988) Modified grid treatment of diabetic perifoveal edema by orange dye laser photocoagulation. Acta Ophthalmol 66:286–292

    Google Scholar 

  33. Reeser F, Fleischmann J, Williams GA, Goldman A (1981) Efficacy of argon laser photocoagulation in the treatment of circinate diabetic retinopathy. Am J Ophthalmol 92:762–767

    Google Scholar 

  34. Rubinstein K, Myska V (1974) Pathogenesis and treatment of diabetic maculopathy. Br J Ophthalmol 58:76–84

    Google Scholar 

  35. Schatz H, Madeira D, McDonald R, Johnson RN (1991) Progressive enlargement of laser scars following grid laser photocoagulation for diffuse diabetic macular edema. Arch Ophthalmol 109:1549–1551

    Google Scholar 

  36. Spalter HF (1971) Photocoagulation of circinate maculopathy in diabetic retinopathy. Am J Ophthalmol 71:242–250

    Google Scholar 

  37. Striph GG, Hart WM, Olk RJ (1988) Modified grid laser photocoagulation for diabetic macular edema. The effect on the central visual field. Ophthalmology 95:1673–1679

    Google Scholar 

  38. Tso MOM (1982) Pathology of cystoid macular edema. Ophthalmology 89:902–915

    Google Scholar 

  39. Varley MP, Frank E, Purnell EW (1988) Subretinal neovascularization after focal argon laser for diabetic macular edema. Ophthalmology 95:567–573

    Google Scholar 

  40. Wallow IH (1984) Repair of the pigment epithelial barrier following photocoagulation. Arch Ophthalmol 102:126–135

    CAS  PubMed  Google Scholar 

  41. Wallow IHL, Bindley CD (1988) Focal photocoagulation of diabetic macular edema. A clinicopathologic case report. Retina 8:261–269

    Google Scholar 

  42. Whitelocke RAF, Kearns M, Blach RK, Hamilton AM (1979) The diabetic maculopathies Trans Ophthalmol Soc UK 99:314–320

    Google Scholar 

  43. Wiznia RA (1979) Photocoagulation of nonproliferative exudative diabetic retinopathy. Am J Ophthalmol 88:22–27

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Massin-Korobelnik, P., Gaudric, A. & Coscas, G. Spontaneous evolution and photocoagulation of diabetic cystoid macular edema. Graefe's Arch Clin Exp Ophthalmol 232, 279–289 (1994). https://doi.org/10.1007/BF00194477

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00194477

Keywords

Navigation