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The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis

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Summary

DNA encoding the human aminopeptidase N (EC 3.4.11.2) gene (PEPN) was first isolated using rat cDNA probes and then used in Southern analysis of DNA from mouse-human somatic cell hybrids to assign this gene to the long-arm region (q11-qter) of human chromosome 15. This human genomic DNA probe detects a frequent DraIII polymorphism that is a useful marker for human chromosome 15.

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Authors and Affiliations

  1. Department of Physiology, University of Toronto, Medical Sciences Building, Room 3360, 1 King's College Circle, M5S 1A8, Toronto, Ontario, Canada

    Valerie M. Watt

  2. Department of Genetics, Stanford University, 94305, Stanford, CA, USA

    Huntington F. Willard

Authors
  1. Valerie M. Watt
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  2. Huntington F. Willard
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Watt, V.M., Willard, H.F. The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis. Hum Genet 85, 651–654 (1990). https://doi.org/10.1007/BF00193592

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  • DOI: https://doi.org/10.1007/BF00193592

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