Abstract
The stratified squamous epithelium of a splenic epidermoid cyst was studied with a battery of monoclonal antibodies to cytokeratin (CK) proteins. CKs 10 and 11 were found in the suprabasal layers of the stratified squamous epithelium, while staining for CK 13 was focal or diffuse throughout. CKs 18 and 19 decorated individual squamous cells or stained the entire thickness of the epithelium. These results were compared with those previously obtained by us in stratified squamous epithelia of ovarian mature cystic teratoma, fetal epidermis, adult epidermis and squamous metaplasia in a peritoneal cyst. From these comparisons it emerges that the epidermoid splenic cyst is either of teratomatous derivation or originates from inclusion of fetal squamous epithelium. Squamous metaplasia of mesothelium or inclusions of mature squamous epithelium appears to be an unlikely source of origin of these cysts.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bhaskaran CS, Rao G, Prasad KRK, Gunwani G (1991) Epidermoid cyst of the spleen — with unusual finding. A case report. Indian J Med Sci 45:88–90
Buerrig K (1988) Epithelial (true) splenic cysts. Pathogenesis of the mesothelial and so-called epidermoid cysts of the spleen. Am J Surg Pathol 12:275–281
Case RH, Gavin DF, Doohen DY (1971) Metaplastic mesodermal cyst of the spleen. Am Surg 37:97–102
Cremades Mira A, Vera-Sempere F, Perez Bacette M, Marin Serra J, Garcia Ballenter M, Llombart-Bosch A (1990) Quiste epidermoide esplenica estudio immunohistoquimico. An Esp Pediatr 33:185–88
Czernobilsky B, Lifschitz-Mercer B, Luzon A, Jacob N, Ben-Hur H, Gorbacz S, Fogel M (1989) Cytokeratin patterns in the epidermis of human ovarian mature cystic teratoma. Hum Pathol 20:185–192
Franke WW, Schmid E, Schiller DL, Winter S, Jarasch ED, Moll R, Denk H, Jackson BW, Illmensee K (1981) Differentiation-related patterns of expression of proteins of intermediate-sized filaments in tissues and cultured cells. Cold Spring Harb Symp Quant Biol 46:431–453
Gaudio M, Brizio R, Medri L, Marra GA, Padovani F, Vio A, Saragoni A (1989) Cisti epidermoidale della milza. Presentazione di un caso. Pathologica 82:465–470
Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabelled antibody (PAP) procedure. J Histochem Cytochem 577–580
Lifschitz-Mercer B, Fogel M, Moll R, Jacob N, Kushnir I, Livoff A, Waldherr R, Franke WW, Czernobilsky B (1991) Intermediate filament profile of human testicular non-seminomatous germ cell tumours: correlation of cytokeratins, especially cytokeratin 19, to cellular differentiation. Differentiation 48:191–198
Miracco C, De Martino A, Botta R, Volterrani L, Luzi P (1986) Splenic cyst lined with mucus-secreting epithelium. Evidence of an intestinal origin. Arch Anat Cytol Pathol 34:304–305
Morinaga S, Ohyama R, Koizumi J (1992) Low-grade mucinous cystadenocarcinoma of the spleen. Am J Surg Pathol 16:903–908
Nerlich A, Permaretter W (1991) Fine needle aspiration. Cytodiagnosis of epidermoid cysts of the spleen. Report of two cases. Acta Cytol 35:567–569
Osborn M, Weber K (1983) Tumor diagnosis by intermediate filament typing. A novel tool for surgical pathology. Lab Invest 48:372–394
Ough YD, Nash ND, Wood DA (1981) Mesothelial cysts of the spleen with squamous metaplasia. Am J Clin Pathol 76:666–669
Panossian D, Wang N, Reeves CD, Weeks DA (1990) Epidermoid cyst of the spleen presenting as generalized peritonitis. Am Surg 56:295–298
Papke J, Radke EU (1990) Primäres malignes Teratom der Milz. Z Gesamte Inn Med 45:172–174
Robbins FG, Yellin AE, Lingua RW, Craig JR, Turrill FL, Mikkelsen WP (1978) Splenic epidermoid cysts. Ann Surg 187:231–235
Talerman A, Hart S (1970) Epithelial cysts of the spleen. Br J Surg 57:201–204
Tsakraklides V, Thomas WH (1973) Epidermoid cysts of the spleen. A report of five cases. Arch Pathol 96:251–254
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lifschitz-Mercer, B., Open, M., Kushnir, I. et al. Epidermoid cyst of the spleen: a cytokeratin profile with comparison to other squamous epithelia. Vichows Archiv A Pathol Anat 424, 213–216 (1994). https://doi.org/10.1007/BF00193502
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00193502