Summary
Wegener's granulomatosis is a rare autoimmune disease characterized by a vasculitis affecting mainly the mucosa of the respiratory tract. Necrosis of the septal mucosa may result in septal perforation and collapse of the cartilaginous part of the nose. Medical treatment of the disease with cyclophosphamides and cortisone usually results in stabilization of the lesions. Until now, surgical correction of the nasal deformities has not been published. We present 2 patients who were operated upon for nasal reconstruction; one without medical treatment, the other after remission of the disease. Techniques and results are presented.
Similar content being viewed by others
References
Barton FF Jr, Byrd HS (1990) Acquired deformities of the nose. In: McCarthy J (ed) Plastic surgery, Chapter 37. Saunders, Philadelphia 3:1979
Brugier JC, Touchard G, Du LTH, Lebranchu Y, Preud'homme JL (1989) Anticorps anti-cytoplasme des polynucléaires neutrophiles dans les vascularités systémiques. Presse Méd 18:225
Cross C, Lllington G (1989) Serodiagnosis of Wegener's granulomatosis: Pathologic and clinical implications (editorial). Mayo Clin Proc 64:119
Domarus H (1975) Residual nasal deformity after Wegener's granuloma. Plast Reconstr Surg 56:216
Drake-Lee A, Bickerton R, Milford C (1988) Wegener's granulomatosis and nasal deformity. Br J Clin Pract 42:348
Du LTH, Wechsler B, Cabane J, Piette JC et al. (1988) Granulomatose de Wegener. Ann Med Interne 139:169
Du LTH, Wechsler B, Piette JC, de Gennes C et al. (1988) Granulomatose de Wegener du sujet age — trente-sept cas. Presse Méd 17:2379
Duncavage J, Durkin G, Lehman R, Toohill R (1985) Dilemmas in the management of chronic nasal and sinus inflammatory diseases of unknown etiology. Laryngoscope 95:1178
Elkon K, Sutherland D, Reese A, Hughes G, Batchelor J (1983) HLA antigen frequencies in system vasculitis: increase in HLA-DR2 in Wegener's granulomatosis. Arthitis Rheum 26:102
Fauci A, Haynes B, Katz P, Wolff S (1983) Wegener's granulomatosis: prospective clinical and therapeutic experience with 85 patients for 21 years. Ann Intern Med 98:76
Harrison D, Simpson R, Kharbanda R, Abernethy V, Nimmo G (1989) Antibodies to neutrophil cytoplasmic antigens in Wegener's granulomatosis and other conditions. Thorax 44:373
Harrison D (1988) Granumomatose de Wegener. (Principles de Medécine Interne) 4e edition française, p 1442
Jackson IT, Reid CD (1978) Nasal reconstruction and lengthening with local flaps. Br J Plast Surg 31:343–348
Kornblut A, Wolff S, de Fries H, Fauci A (1980) Wegener's granulomatosis. Laryngoscope 90:1453
Parlevliet K, Henzen-Logmans S, Bronsveld P, Balm A, Donker A (1988) Antibodies to components of neutrophil cytoplasm: a new diagnostic tool in patients with Wegener's granulomatosis and system vasculitis. Med 66:55
Savage C, Winearle C, Jones S, Marshall P, Lockwood C (1987) Prospective study of radioimmunoassay for antibodies against neutrophil cytoplasm in diagnosis of systemic vasculitis. Lancet 1389
Specks U, Wheatley CH, McDonald T, Rohrbach M, DeRemee R (1989) Anticytoplasmic autoantibodies in the diagnosis and follow-up of Wegener's granulomatosis. Mayo Clin Proc 64:28
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Abboud, M., Lejour, M. & Greuse, M. Nasal reconstruction in Wegener's disease. Eur J Plast Surg 15, 41–44 (1992). https://doi.org/10.1007/BF00193377
Issue Date:
DOI: https://doi.org/10.1007/BF00193377