Skip to main content
SpringerLink
Log in

Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Aaseth J (1975) The effect of N-acetyl-DL-homocysteine and its thiolactone on the distribution and excretion of mercury in methylmercury chloride injected mice. Acta Pharmacol Toxicol 36: 193–202.

    Google Scholar 

  • Ally A, Phipps J, Miller DR (1984) Interaction of methylmercury chloride with cellular energetics and related processes. Toxicol Appl Pharmacol 76: 207–218.

    Google Scholar 

  • Cheung M, Verity MA (1981) Methylmercury inhibition of synaptosome protein synthesis. The role of mitochondrial dysfunction. Environ. Res 24: 286–298.

    Google Scholar 

  • Fiske CH, Subbarow Y (1925) The colorimetric determination of phosphorus. J Biol Chem 66: 375–400.

    CAS  Google Scholar 

  • Hargreaves RJ, Foster JR, Pelling D, Moorhouse SR, Gangolli SD, Rowland IR (1985) Changes in the distribution of histochemically localized mercury in the CNS and in tissue levels of organic and inorganic mercury during the development of intoxication of methylmercury treated rats. Neuropathol Appl Neurobiol 11: 383–401.

    Google Scholar 

  • Hinton DE, Koeing JC (1975) Acid phosphatase activity in subcellular fractions of fish liver exposed methylmercuric chloride. Comp Biochem Physiol 50: 621–625.

    Google Scholar 

  • Lapresle C, Webb T (1962) Biochem J 84: 455–462 In: Dingle JT (ed) (1972) Lysosomes —A laboratory hand book, North-Holland Publishing Co., Amsterdam, London, p 45.

  • Lauwerys R, Buchet JD (1972) Study on the mechanism of lysosome labilization by inorganic mercury In vitro. Eur J Biochem 26: 535–542.

    Google Scholar 

  • Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein measurement with Folin-phenol reagent. J Biol Chem 193: 265–275.

    CAS  PubMed  Google Scholar 

  • Mulder KM, Kostyniak PJ (1985) Involvement of glutathione in the enhanced renal excretion of methylmercury in CFW Swiss mice. Toxicol Appl Pharmacol 78: 451–457.

    Google Scholar 

  • Nadler HL (1973) Acid phosphatase deficiency. In: Hers HG, Van Hoof F (eds) Lysosomes and storage diseases. Acad Press, New York, p 474.

    Google Scholar 

  • Omata S, Momose Y, Ueki H, Sugano H (1982) In vivo effect of methylmercury on protein synthesis in peripheral nervous tissues of rat. Arch Toxicol 49: 203–214.

    Google Scholar 

  • Shinowara GY, Jones JM, Reinhart HL (1942) The estimation of serum inorganic phosphate and acid and alkaline phosphatase activity. J Biol Chem 142: 912–921.

    Google Scholar 

  • Sokal RR, Rohlf FJ (1969) Biometry. Freeman & Co., San Fransisco, p 227.

    Google Scholar 

  • Sood PP, Unnikumar KR, Vinay SD, Raghu KG, Wegmann R (1988) Duration dependent effect of methylmercury chloride and antagonists on the enzymes of the central nervous system of rat. II Acid phosphatase study on the brain. Cell Mol Biol 34: 271–277.

    Google Scholar 

  • Thomas DJ, Richards AD, Kay J (1989) Inhibition of aspartic proteinase by alpha2-macroglobulin. Biochem J 259: 905–907.

    Google Scholar 

  • Thorlacius-Ussing 2O, Graabek PM (1986) Simultaneous ultrastructural demonstration of heavy metals (silver, mercury) and acid phosphatase. Histochem J 18: 639–646.

    Google Scholar 

  • Vinay SD, Raghu KG, Sood PP (1990) Dose and duration related methylmercury deposition, glycosidases inhibition, myelin degeneration and chelation therapy. Cell Mol Biol 36: 609–623.

    Google Scholar 

  • Vinay SD, Sood PP (1991) Inability of thiol compounds to restore CNS arylsulfatases inhibited by methylmercury. Pharmacol Toxicol 69: 71–74.

    Google Scholar 

  • Yonezawa S, Fujii K, Maejima Y, Tamoto K, Mori Y, Muto N (1988) Further studies on rat cathepsin E: Subcellular localization and existence of the active subunit form. Arch Biochem Biophys 267: 176–183.

    Google Scholar 

  • Yoshino Y, Mozai T, Nakao K (1966) Biochemical changes in the brain in rats poisoned with an alkylmercury compound with special reference to the inhibition of protein synthesis in brain cortex slices. J Neurochem 13: 1223–1230.

    Google Scholar 

  • Zimmer L, Carter DE (1979) Effect of complexing treatment administered with the onset of methylmercury neurotoxic signs. Toxicol Appl Pharmacol 51: 29–37.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Neurobiology, Department of Biosciences, Saurashtra University, 360 005, Rajkot, India

    S. D. Vinay, K. G. Raghu & P. P. Sood

Authors
  1. S. D. Vinay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. G. Raghu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. P. Sood
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vinay, S.D., Raghu, K.G. & Sood, P.P. Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat. Bull. Environ. Contam. Toxicol. 49, 78–84 (1992). https://doi.org/10.1007/BF00193344

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00193344

Keywords

Search

Navigation