Skip to main content
Log in

The growth of long bones in human embryological and fetal upper limbs and its relationship to other developmental patterns

  • Original Articles
  • Published:
Anatomy and Embryology Aims and scope Submit manuscript

Abstract

Measurements were made of the long bones of the upper limbs (humerus, ulna, radius) of 58 aborted embryos and fetuses, developmental age from 8 to 14 weeks, crown-rump length (CRL) between 38 and 116 mm. The specimens were cleared and double-stained, using alcian blue and alizarin red S for a differential detection of cartilage and bone. The values of both the total length (TL) and the ossified part (OL) of each long bone were related to the fetal developmental age previously estimated by freshly measured CRL. The relationship to another developmental pattern, i.e. the number of ossified centres in the vertebral column, suggested that the OL values could be much more significant than TL for the assessment of fetal growth.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Bade P (1900) Die Entwicklung des menschlichen Skelets bis zur Geburt. Arch Mikrosk Anat Entw 55:245–290

    Google Scholar 

  • Bagnall KM, Harris PF, Jones PRM (1982) A radiographic study of the longitudinal growth of primary ossification centres in limb long bones of human fetus. Anat Rec 203:293–299

    Google Scholar 

  • Bareggi R, Grill V, Sandrucci MA, Baldini G, De Pol A, Forabosco A, Narducci P (1993) Developmental pathways of vertebral centra and neural arches in human embryos and fetuses. Anat Embryol 187:139–144

    Google Scholar 

  • Chiarasini D, Barbet JP, Copin H, Maillet M, Pompidou A (1992) Scanning electron microscopy of femural ossification in the human fetus. Bull Assoc Anat (Nancy) 233:13–21

    Google Scholar 

  • Dingerkus G, Ühler LD (1977) Enzyme clearing of Alcian Blue stained whole small vertebrates for demonstration of cartilage. Stain Technol 52:229–232

    Google Scholar 

  • Felts WJL (1954) The prenatal development of the human femur. Am J Anat 9:1–44

    Google Scholar 

  • Gardner E, Gray DJ (1969) The prenatal development of the human femur. Am J Anat 129:121–140

    Google Scholar 

  • Kalifa G, Barbet JP, Labbe F, Houette A, Sellier N (1989) Value of systematic post mortem radiographic examinations of fetuses — 400 cases. Pediatr Radiol 19:111–113

    Google Scholar 

  • Kelemen E, Janossa M, Calvo W, Fliedner TM (1984) Developmental age estimated by bone-length measurement in human fetuses. Anat Rec 209:547–552

    Google Scholar 

  • Kelly WL, Bryden M (1983) A modified differential stain for cartilage and bone in whole mount preparations of mammalian fetuses and small vertebrates. Stain Technol 58:131–134

    Google Scholar 

  • Kimmel CA, Trammell C (1981) A rapid procedure for routine double staining of cartilage and bone in fetal and adult animals. Stain Technol 56:271–273

    Google Scholar 

  • Mall F (1906) On ossification centres in human embryos less than one hundred days old. Am J Anat 5:433–458

    Google Scholar 

  • Mehta L, Singh HM (1972) Determination of crown rump length from fetal long bones: humerus and femur. Am J Phys Anthropol 36:165–168

    Google Scholar 

  • Moss ML, Noback CR, Robertson GC (1955) Critical developmental horizon in human fetal long bones. Am J Anat 97:155–175

    Google Scholar 

  • Seeds JW, Cefalo RC (1982) Relationship of fetal limb lengths to both biparietal diameter and gestational age. Obstet Gynecol 60:680–685

    Google Scholar 

  • Vasconcellos HA, Prates JC, Moraes LGB, Rodriques HC (1992) Growth of the human metatarsal bones in the fetal period (13–24 weeks postconception): a quantitative study. Surg Radiol Anat 14:315–318

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bareggi, R., Grill, V., Zweyer, M. et al. The growth of long bones in human embryological and fetal upper limbs and its relationship to other developmental patterns. Anat Embryol 189, 19–24 (1994). https://doi.org/10.1007/BF00193126

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00193126

Key words

Navigation