Abstract
This study assessed the influence of acetylsalicylic acid (ASA, 1.0 g), ibuprofen (0.8 g) and paracetamol (1.0 g) on the single-dose kinetics of ethanol in 12 healthy volunteers ingesting the drug and a standardised 1840-kJ breakfast 1 h before intake of ethanol. It also assessed the influence of ethanol on the single-dose kinetics of 1.0 g ASA in ten fasting healthy volunteers. Plasma concentrations of ethanol were measured by gas chromatography, and those of the drugs by liquid chromatography. There was no effect of ASA, ibuprofen or paracetamol on the single-dose kinetics of ethanol, but concurrent intake of ethanol reduced the peak concentration of ASA by 25%.
Similar content being viewed by others
References
DiPadova C, Worner TM, Julkunen RJK, Lieber CS (1987) Effects of fasting and chronic alcohol consumption on the first-pass metabolism of ethanol. Gastroenterology 92:1169–1173
Melander A, Lalka D, McLean A (1988) Influence of food on the presystemic metabolism of drugs. Pharmacol Ther 38:253–267
Pirola RC. (1977) Drug metabolism and alcohol. Aids, Sydney
Fenn CG, Littleton JM (1982) Inhibition of platelet aggregation by ethanol in vitro shows specificity for aggregating agent and is influenced by platelet lipid composition. Thromb Haemost 48:49–53
Deykin D, Janson P, McMahon L. (1982) Ethanol potentiation of aspirin-induced prolongation of the bleeding time. N Engl J Med 306:852–854
Roine R, Gentry T, Hernández-Munoz R, Baraona E, Lieber CS (1990) Aspirin increases blood alcohol concentrations in humans after ingestion of ethanol. J Am Med Assoc 264:2406–2408
Melander A, McLean A (1983) Influence of food on presystemic clearance of drugs. Clin Pharmacokinet 8:286–297
Manno BR, Manno JE (1978) A simple approach to gas chromatographic microanalysis of alcohol in blood and urine by a direct-injection technique. J Anal Toxicol 2:257–261
W»hlin-Boll E, Brantmark B, Hanson A, Melander A, Nilsson C (1981) High-pressure liquid chromatographic determination of acetylsalicylic acid, salicylic acid, diflunisal, indomethacin, indoprofen and indobufen. Eur J Clin Pharmacol 20:375–378
Brantmark B, W»hlin-Boll E, Melander A (1982) Bioavailability of acetylsalicylic acid and salicylic acid from rapid- and slow-release formulations, and in combination with dipyridamole. Eur J Clin Pharmacol 22:309–314
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Melander, O., Lidén, A. & Melander, A. Pharmacokinetic interactions of alcohol and acetylsalicylic acid. Eur J Clin Pharmacol 48, 151–153 (1995). https://doi.org/10.1007/BF00192741
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00192741