Summary
The effect of pentoxifylline as a hemorrheologic agent on skin flap survival has been observed. A caudally pedicled dorsal flap with an ischemic component in rats was used as the model. The flap survival was calculated to be 0.807±0.049 in the control group (n = 15), where flap survival was found to be 0.9713±0.018 in the pentoxifylline treated group (n = 15) (t = 12.19, p < 0.005). In the meantime, living flap length was measured as 9.96±0.72 in the control group, and 11.84±0.18 in the pentoxifylline treated group. With these results, we have come to the conclusion that parenteral pentoxifylline therapy is effective on ischemic skin flap survival in the rat model.
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References
Chu BC, Desmukh N (1989) The lack of effect of pentoxifylline on random skin flap survival. Plast Reconstr Surg 83:315–318
Ehrly AM (1976) Improvement of the flow proportions of blood: a new therapeutic approach in occlusive arterial disease. Angiology 27:188
Finseth F (1979) Clinical salvage of three failing skin flaps by treatment with a vasodilator drug. Plast Reconstr Surg 63:304
Freedman AM, Bogart GC, Key D, Hyde GL (1986) The effect of pentoxifylline on skin flap survival in the rat. South Med J 79:48
Grabb W, Smith J (1980) Plastic surgery, 3rd edn. Little Brown, Boston, pp 36–44
McFarlane RM, Deyoung G, Henry RA (1965) The design of a pedicle flap in the rat to study necrosis and its prevention. Plast Reconstr Surg 35:177
Monteiro DT, Santamore WP, Nemir P (1976) The influence of pentoxifylline on skin flap survival. Plast Reconstr Surg 77:277
Porter JM, Cutler BS, Le Bok Y, Reich T, Reichle F, Scogin JT, Strandness DE (1982) Pentoxifyfine efficacy in the treatment of intermittent claudication: multicenter controlled double-blind triad with objective assessment of chronic occlusive arterial disease. Am Heart J 104:66
Roth AG, Briggs PC, Jones EW, Heckler FR (1988) Augmentation of skin flap survival by parenteral pentoxifylline. Br J Plast Surg 41:515
Takayanagi S, Ogawa Y (1980) Effects of pentoxifylline on flap survival. Plast Reconstr Surg 65:763
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Correspondence to: M. Topalan, MD
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Topalan, M., Arinci, A., Erer, M. et al. The effect of parenteral pentoxifylline therapy on skin flap survival. Eur J Plast Surg 16, 33–35 (1993). https://doi.org/10.1007/BF00192704
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DOI: https://doi.org/10.1007/BF00192704