Skip to main content

Advertisement

SpringerLink
Log in

Second cancer after treatment of malignant germ-cell tumors

  • Published:
World Journal of Urology Aims and scope Submit manuscript

Summary

Patients cured of a malignant germ-cell tumor are at a significantly increased relative risk (RR, 1.3–2.1) of developing a new malignancy, the most frequent second cancer being a new germ-cell cancer. The exact role of modern treatment of germ-cell malignancies as an etiological factor of a subsequent cancer has not yet been defined. The relative risk of developing a new non-germ-cell cancer, however, seems especially high after intensive cytotoxic treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bosl GJ, Dmitrovsky E, Reuter VE, Samaniego F, Rodriguez E, Geller NL, Chaganti RSK (1989) Isochromosome of chromosome 12: clinically useful marker for male germ cell tumors. J Natl Cancer Inst 81:1874–1878

    Google Scholar 

  2. Bottomley D, Fisher C, Hendry WF, Horwich A (1990) Persistent carcinoma is situ of the testis after chemotherapy for advanced testicular germ cell tumours. Br J Urol 66:374–376

    Google Scholar 

  3. Daugaard G, Rørth M, Maase H von der, Skakkebæk NE (1992) Management of extragonadal germ-cell tumors and the significance of bilateral testicular biopsies. Ann Oncol 3:283–289

    Google Scholar 

  4. Flannary JT, Boice JD, Devesa SS, Kleinerman RA, Curtis RE, Fraumeni JF (1985) Cancer registration in Connecticut and the study of multiple primary cancers, 1935–82. Natl Cancer Inst Monogr 68:13–24

    Google Scholar 

  5. Fosså SD, Aass N (1989) Cisplatin based chemotherapy does not eliminate the risk of a second testicular cancer. Br J Urol 63:531–534

    Google Scholar 

  6. Fosså SD, Langmark F, Aass N, Andersen A, Lothe R, Børresen AL (1990) Second non-germ cell malignancies after radiotherapy of testicular cancer with or without chemotherapy. Br J Cancer 61:639–643

    Google Scholar 

  7. Fosså SD, Aass N, Ous S, Wæhre H (1991) Long-term morbidity in testicular cancer. Scand J Urol Nephrol [Suppl] 138:241–246

    Google Scholar 

  8. Giwercman A, Maase H von der, Skakkebæk NE (1993) Epidemiological and clinical aspects of carcinoma in situ of the testis. Eur Urol 23:104–114

    Google Scholar 

  9. Glanzmann C, Schultz G, Lütolf UM (1991) Long-term morbidity of adjuvant infradiphragmatic irradiation in patients with testicular cancer and implications for the treatment of stage I seminoma. Radiother Oncol 22:12–18

    Google Scholar 

  10. Greist A, Einhorn LH, Williams J, Donohue JP, Rowland RG (1984) Pathologic findings at orchiectomy following chemotherapy for disseminated testicular cancer. J Clin Oncol 2:1025–1030

    Google Scholar 

  11. Hanks GE, Peters T, Owen JO (1992) Seminoma of the testis: long-term beneficial and deleterious results of radiation. Int J Radiat Oncol Biol Phys 24:913–919

    Google Scholar 

  12. Harland SJ, Cook PA, Fosså SD, Horwich A, Parkinson MC, Roberts JT, Stenning SP (1993) Risk factors for carcinoma in situ of the contralateral testis in patients with testicular cancer. Eur Urol 23:115–119

    Google Scholar 

  13. Hay JH, Duncan W, Kerr GR (1984) Subsequent malignancies in patients irradiated for testicular tumours. Br J Radiol 57:597–602

    Google Scholar 

  14. Heikkilä R, Heilo A, Stenwig AE, Fosså SD (1993) Testicular ultrasonography and 18G Biopty for clinically undetected cancer or carcinoma in situ in patients with germ cell tumours. Br J Urol 71:214–216

    Google Scholar 

  15. Heimdal K, Evensen SA, Fosså SD, Hirschberg H, Langholm R, Brøgger A, Møller P (1991) Karyotyping of a haematological neoplasma developing shortly after treatment for cerebral extragonadal germ cell tumor. Cancer Genet Cytogenet 57:41–46

    Google Scholar 

  16. Hellbardt A, Mirimanoff R-O, Obradovic M, Mermillod B, Paunier J-P (1990) The risk of second cancer (SC) in patients treated for testicular seminoma. Int J Radiat Oncol Biol Phys 18:1327–1331

    Google Scholar 

  17. Hoff Wanderås E, Fosså SD, Heilo A, Stenwig AE, Norman N (1990) Serum follicle stimulating hormone — predictor of cancer in the remaining testis in patients with unilateral testicular cancer. Br J Urol 66:315–317

    Google Scholar 

  18. Horwich A, Bell J (1991) Late mortality after radiotherapy for stage I seminoma of the testis. Eur J Cancer ECCO 6:639

    Google Scholar 

  19. Kaldor JM, Day NE, Band P, Chor NW, Clarke EA, Coleman MP, Hakama M, Koch M, Langmark F, Neal FE, Pettersson F, Pompe-Kirn V, Strom HH (1987) Second malignancies following testicular cancer, ovarian cancer and Hodgkin's disease: an international collaborative study among cancer registries. Int J Cancer 39:571–585

    Google Scholar 

  20. Kleinermann RA, Liebermann JV, Li FP (1985) Second cancer following cancer of the male genital system in Connecticut, 1935–82. Natl Cancer Inst Monogr 68:139–147

    Google Scholar 

  21. Kratzik C, Aigninger P, Kuber W, Riccabona M, Kührer I, Koos H, Frick J, Amann G, Mayr W (1991) Risk factors for bilateral testicular germ cell tumors. Cancer 68:916–921

    Google Scholar 

  22. Leeuwen FE van, Stiggelbout AM, Belt-Dusebout AW van den, Noyan R, Eliel MR, Kerkhoff EHM van, Delemarre JFM, Somers R (1993) Second cancer risk following testicular cancer: a follow-up study of 1909 patients. J Clin Oncol 11:415–424

    Google Scholar 

  23. Linassier C, Poumier-Gaschard P, Bremond J-L, Barin C, Haillot Om Lamagnere JP, Colombat P (1992) Simultaneous occurrence of acute myelogenous leukemia and seminoma of the testis. Cancer Chemother Pharmacol 30:233–234

    Google Scholar 

  24. Loy V, Dieckmann K-P (1993) Prevalence of contralateral testicular intraepithelial neoplasia (carcinoma in situ) in patients with testicular germ cell tumour. Eur Urol 23:120–122

    Google Scholar 

  25. Maase H von der, Rørth M, Walbom-Jørgensen S, et al (1986) Carcinoma-in-situ of the contralateral testis in patients with testicular germ cell cancer. Study of 27 cases in 500 patients. BMJ 293:1398–1401

    Google Scholar 

  26. Møller H, Mellemgaard A, Jacobsen GK, Pedersen D, Storm HH (1993) Incidence of second primary cancer following testicular cancer. Eur J Cancer 5:672–676

    Google Scholar 

  27. Østerlind A, Rørth M, Prener A (1985) Second cancer following cancer of the male genital system in Denmark, 1943–80. Natl Cancer Inst Monogr 68:341–347

    Google Scholar 

  28. Østerlind A, Berthelsen JG, Abildgaard N, Hansen SO, Hjalgrim H, Johansen B, Munck-Hansen J, Rasmussen LH (1991) Risk of bilateral testicular germ cell cancer in Denmark, 1969–1984. J Natl Cancer Inst 83:1391–1395

    Google Scholar 

  29. Pedersen-Bjergaard J, Hansen SW, Larsen SO, Daugaard G, Philip P, Rørth M (1991) Increased risk of myelodysplasia and leukaemia after etoposide, cisplatin, and bleomycin for germ-cell tumours. Lancet 338:359–363

    Google Scholar 

  30. Redman JR, Vugrin D, Arlin ZA, Gee TS, Kempin SJ, Goldbold JH, Schottenfeld D Clarksjon BD (1984) Leukemia following treatment of germ cell tumors in men. J Clin Oncol 10:1080–1987

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Oncology and Radiotherapy, The Norwegian Radium Hospital, N-0310, Oslo, Norway

    S. D. Fosså, E. Hoff Wanderås & K. Heimdal

  2. Department of Genetics, The Norwegian Radium Hospital, N-0310, Oslo, Norway

    E. Hoff Wanderås & K. Heimdal

Authors
  1. S. D. Fosså
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Hoff Wanderås
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Heimdal
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fosså, S.D., Wanderås, E.H. & Heimdal, K. Second cancer after treatment of malignant germ-cell tumors. World J Urol 12, 151–154 (1994). https://doi.org/10.1007/BF00192277

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00192277

Keywords

Search

Navigation