Abstract
The pseudorabies virus glycoprotein III (PrV-gIII) has been identified previously as the major viral component binding to a heparin-like receptor on the surface of target cells. The amino acid sequence of gIII contains three regions corresponding to consensus sequences for heparin binding. A synthetic peptide corresponding to amino acids 134 to 141 of PrV-gIII bound heparin in a dot blot assay. In contrast, a synthetic peptide derived from amino acids 290–299 of PrV-gIII did not bind heparin. We therefore conclude that the region containing amino acid 134–141 is involved in binding to the heparin-like cellular receptor.
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Sawitzky, D., Voigt, A. & Habermehl, KO. A peptide-model for the heparin-binding property of pseudorabies virus glycoprotein III. Med Microbiol Immunol 182, 285–292 (1993). https://doi.org/10.1007/BF00191944
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DOI: https://doi.org/10.1007/BF00191944